DRSC/TRiP Functional Genomics Resources

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Protein Alignment HOXA2 and Dfd

DIOPT Version :10

Sequence 1:NP_006726.1 Gene:HOXA2 / 3199 HGNCID:5103 Length:376 Species:Homo sapiens
Sequence 2:NP_477201.1 Gene:Dfd / 40832 FlyBaseID:FBgn0000439 Length:586 Species:Drosophila melanogaster


Alignment Length:240 Identity:72/240 - (30%)
Similarity:97/240 - (40%) Gaps:68/240 - (28%)


- Green bases have known domain annotations that are detailed below.


Human    95 YPWMKEKKAAKKTALLPAAAAAATAAATGPACLSHKESLEIADGS---GGGSRRLRTAYTNTQLL 156
            |||||:...|                             .:|:||   |...:|.|||||..|:|
  Fly   344 YPWMKKIHVA-----------------------------GVANGSYQPGMEPKRQRTAYTRHQIL 379

Human   157 ELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQCKENQNSEGKCKSLEDSE 221
            |||||||:|:||.|.||:|||..|.|:|||:|:||||||||.|:..:....:|...|......: 
  Fly   380 ELEKEFHYNRYLTRRRRIEIAHTLVLSERQIKIWFQNRRMKWKKDNKLPNTKNVRKKTVDANGN- 443

Human   222 KVEEDEEEKTLFEQALSVSGALLEREGYTFQQNALSQQQAPNGHNGDSQSFPVSPLTSNEKNLKH 286
                          ...|:....:|.....||.|..|||:   ....:|..||........:|:.
  Fly   444 --------------PTPVAKKPTKRAASKKQQQAQQQQQS---QQQQTQQTPVMNECIRSDSLES 491

Human   287 FQHQS---------PTVPNCLSTM---------GQNCGAGLNNDS 313
            ....|         |..|...|:.         ..|.|:|.||::
  Fly   492 IGDVSSSLGNPPYIPAAPETTSSYPGSQQHLSNNNNNGSGNNNNN 536

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HOXA2NP_006726.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 42..93
Antp-type hexapeptide 94..99 3/3 (100%)
Homeodomain 144..200 CDD:459649 38/55 (69%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 198..229 3/30 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 257..279 6/21 (29%)
DfdNP_477201.1 Homeodomain 367..423 CDD:459649 38/55 (69%)
Blue background indicates that the domain is not in the aligned region.

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