Protein Alignment HOXA2 and bcd

DIOPT Version :10

• Sequence 1: NP_006726.1
• Gene: HOXA2 / 3199
• HGNCID: 5103
• Length: 376
• Species: Homo sapiens
• Sequence 2: NP_788587.1
• Gene: bcd / 40830
• FlyBaseID: FBgn0000166
• Length: 494
• Species: Drosophila melanogaster
• Alignment Length: 442
• Identity: 100/442 - (22%)
• Similarity: 146/442 - (33%)
• Gaps: 173/442 - (39%)

Human    49 PPPFEQTIPSLNPGSHPRHGAGGRPKPSPAGSRGSPVPAGALQ-PPEY----------------- 95
            |.|...|.|  :|.|||      .|...|......|    .|| ||::
  Fly    14 PLPHTHTHP--HPHSHP------HPHSHPHPHHQHP----QLQLPPQFRNPFDLLFDERTGAINY 66

Human    96 ----PWMKEKKAAKKTALLPAAAAAATAAATGPACLSHKESLEIADGSGGGSRRLRTAYTNTQLL 156
                |::..:  ..|..:.|:.....:.....|                   ||.||.:|::|:.
  Fly    67 NYIRPYLPNQ--MPKPDVFPSEELPDSLVMRRP-------------------RRTRTTFTSSQIA 110

Human   157 ELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQCKENQNSEGKCKSLEDSE 221
            |||:.|...:||..||..:::|.|.|...|||:||:|||.:||.|:...::|:.||  ..|....
  Fly   111 ELEQHFLQGRYLTAPRLADLSAKLALGTAQVKIWFKNRRRRHKIQSDQHKDQSYEG--MPLSPGM 173

Human   222 KVEEDEEEKTLFEQALSVSGALLEREGYTFQQNALSQQQAPN----------------------G 264
            | :.|.:..:|  |.||:.|      |.|  .|||:....|:                      |
  Fly   174 K-QSDGDPPSL--QTLSLGG------GAT--PNALTPSPTPSTPTAHMTEHYSESFNAYYNYNGG 227

Human   265 HNGDS------QSFP----VSPLTSNEKNLKHFQ------------HQSPTVPNCLSTMGQN--- 304
            ||...      ..:|    ..|.::|....:.||            ||...||:.:....|.
  Fly   228 HNHAQANRHMHMQYPSGGGPGPGSTNVNGGQFFQQQQVHNHQQQLHHQGNHVPHQMQQQQQQAQQ 292

Human   305 ---------------CGAGLNNDSPEALEVPSLQDFSVFST-------DSCLQLSDAV------- 340
                           |.. |..|.|||       |::..|:       ......:.||
  Fly   293 QQYHHFDFQQKQASACRV-LVKDEPEA-------DYNFNSSYYMRSGMSGATASASAVARGAASP 349

Human   341 --------------SPSLPG-SLDSPVDI------SADSLDFFTDTLTTIDL 371
                          ||||.| .:..|..|      :||.:|..|...||:.:
  Fly   350 GSEVYEPLTPKNDESPSLCGIGIGGPCAIAVGETEAADDMDDGTSKKTTLQI 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXA2	NP_006726.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	42..93		13/44 (30%)
		Antp-type hexapeptide	94..99		1/25 (4%)
		Homeodomain	144..200	CDD:459649	26/55 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	198..229		9/30 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..279		6/53 (11%)
bcd	NP_788587.1	Homeodomain	106..153	CDD:459649	20/46 (43%)