DRSC/TRiP Functional Genomics Resources

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Protein Alignment HOXA2 and pb

DIOPT Version :10

Sequence 1:NP_006726.1 Gene:HOXA2 / 3199 HGNCID:5103 Length:376 Species:Homo sapiens
Sequence 2:NP_476669.3 Gene:pb / 40826 FlyBaseID:FBgn0051481 Length:782 Species:Drosophila melanogaster


Alignment Length:372 Identity:126/372 - (33%)
Similarity:155/372 - (41%) Gaps:135/372 - (36%)


- Green bases have known domain annotations that are detailed below.


Human     8 EIGFINSQPSLAECLTSFPPVADTFQSSSIKTSTLSHSTLIPPPFEQTIPSLNPGSHPRHGAGGR 72
            |.||||||||:||.|....|     :|..|.|..                    ||....|.|..
  Fly    97 EGGFINSQPSMAEFLNHLSP-----ESPKIGTPV--------------------GSGAIGGVGVN 136

Human    73 PKPSPAGSRGSPV------PAGALQPPEYPWMKEKKAAKK------------TALLPAAAAAATA 119
            ...:.....|.||      |.|....||||||||||.::|            |..:|        
  Fly   137 VNVNVGVGVGYPVGVVPQTPDGMDSVPEYPWMKEKKTSRKSSNNNNQGDNSITEFVP-------- 193

Human   120 AATGPACLSHKESLEIADGSGGGSRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTE 184
                               ..|..||||||||||||||||||||||||||||||:||||.|||||
  Fly   194 -------------------ENGLPRRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTE 239

Human   185 RQVKVWFQNRRMKHKRQTQCKENQNSEGKCKSLEDSEKVEEDEEEKTLFEQALSVSGALLEREGY 249
            ||||||||||||||||||..|.:....      :||.|.::|:                      
  Fly   240 RQVKVWFQNRRMKHKRQTLSKTDDEDN------KDSLKGDDDQ---------------------- 276

Human   250 TFQQNALSQQQAPNGHNGDSQSFPVSPLTSNEKNLKHFQHQSPTVPNCLSTMGQNCGAGLNNDSP 314
                             .||.|       :::|:.:..:..|..:|:..|.     ..|.||::|
  Fly   277 -----------------SDSNS-------NSKKSCQGCELPSDDIPDSTSN-----SRGHNNNTP 312

Human   315 EAL-EVPSLQDFSVFSTDSCLQLSDAVSPSLPGS--LDSPVDISADS 358
            .|. ..||..:.:..|:     |...:|.:|.||  :.:...|||||
  Fly   313 SATNNNPSAGNLTPNSS-----LETGISSNLMGSTTVSASNVISADS 354

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HOXA2NP_006726.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 42..93 9/56 (16%)
Antp-type hexapeptide 94..99 4/4 (100%)
Homeodomain 144..200 CDD:459649 53/55 (96%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 198..229 10/30 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 257..279 3/21 (14%)
pbNP_476669.3 Homeodomain 199..255 CDD:459649 53/55 (96%)

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