DRSC/TRiP Functional Genomics Resources

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Protein Alignment HOXA2 and exex

DIOPT Version :10

Sequence 1:NP_006726.1 Gene:HOXA2 / 3199 HGNCID:5103 Length:376 Species:Homo sapiens
Sequence 2:NP_648164.1 Gene:exex / 38884 FlyBaseID:FBgn0041156 Length:525 Species:Drosophila melanogaster


Alignment Length:229 Identity:69/229 - (30%)
Similarity:95/229 - (41%) Gaps:57/229 - (24%)


- Green bases have known domain annotations that are detailed below.


Human    24 SFPPVADTFQSSSIKTSTLSHSTLIP-----------PPFEQTIPSLNP----------GSHPRH 67
            |.||:     |...:.....|..|.|           ..|::.||..:|          |.||..
  Fly   317 SSPPI-----SPGCEDQQQPHGALHPQHLSMRMSDFHDEFKKPIPPHSPIRPQDFPLYAGGHPYQ 376

Human    68 --GAGGRPKPSPAGSRGSPVPAGALQPPEYPWMKEK-------KAAKKTALLPAAAAAATAAATG 123
              ..||.....|....|.|:|.    |..:.:|..:       :|......:|..||        
  Fly   377 LLAQGGSAFHRPLDPSGKPIPI----PMGHNFMPSQLQFEFLARAGMLHHRIPELAA-------- 429

Human   124 PACLSHKESLEIADGSGGGSRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVK 188
               ..|...|       |.:||.|||:|:.|||||||:|..||||.||:|.|:|:.|.|:|.|||
  Fly   430 ---YPHHAIL-------GKTRRPRTAFTSQQLLELEKQFKQNKYLSRPKRFEVASGLMLSETQVK 484

Human   189 VWFQNRRMKHKRQTQCKENQNSEGKCKSLEDSEK 222
            :||||||||.||..:.::......|....:..::
  Fly   485 IWFQNRRMKWKRSKKAQQEAKERAKANQQQQQQQ 518

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HOXA2NP_006726.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 42..93 16/73 (22%)
Antp-type hexapeptide 94..99 0/4 (0%)
Homeodomain 144..200 CDD:459649 37/55 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 198..229 3/25 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 257..279
exexNP_648164.1 Homeodomain 440..496 CDD:459649 37/55 (67%)
Blue background indicates that the domain is not in the aligned region.

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