DRSC/TRiP Functional Genomics Resources

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Protein Alignment HOXA2 and Dbx

DIOPT Version :10

Sequence 1:NP_006726.1 Gene:HOXA2 / 3199 HGNCID:5103 Length:376 Species:Homo sapiens
Sequence 2:NP_647677.2 Gene:Dbx / 38254 FlyBaseID:FBgn0261723 Length:741 Species:Drosophila melanogaster


Alignment Length:247 Identity:54/247 - (21%)
Similarity:92/247 - (37%) Gaps:75/247 - (30%)


- Green bases have known domain annotations that are detailed below.


Human   118 ALEDEPEGPGVHVSNSQLRQKISSLETKLKASEEEKQ-----RI-----KKDVESLMEKHSVLEK 172
            |.||.||....|::.....|...:|.....:|:...|     |:     |..:|:.:|...||::
  Fly   291 AAEDLPEELIFHINYLGADQPTFTLNFSKGSSQIIAQYYQLIRLGFEGYKNVMENCIENMVVLKE 355

Human   173 GFLK-------EKEQ--DAVSFQARYRELQEKHKQELEDM-RKAGHEALSIIVDEYKALLQSSVK 227
            |..|       .|:|  ..|:|..:......:.  |:.:| |:.|.     ||..|        .
  Fly   356 GIEKTERFNIVSKDQGVPVVAFSLKDHSFHNEF--EISEMLRRFGW-----IVPAY--------T 405

Human   228 QQLDAIEKQYVSAI-----EKQAHRCEELLHAQHQRLLDVLDTEKELLREKIQ-EALTQQSQEQK 286
            ...||   |:::.:     |..:....|.|.|...::|..|||....:.:|:. |.:.:..:|: 
  Fly   406 MPADA---QHITVLRVVIREDFSRTLAERLVADISKVLHELDTLPSKISKKMGIEGIAENVKEK- 466

Human   287 ESLEKCLQEEMQRNKETLESAVKLEKEAMKDVITKAVG-----EERENLEKV 333
                                  |:|||.:.:||   ||     :||:.:..|
  Fly   467 ----------------------KMEKEILMEVI---VGWRKFVKERKKMNGV 493

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HOXA2NP_006726.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 42..93
Antp-type hexapeptide 94..99
Homeodomain 144..200 CDD:459649 14/74 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 198..229 7/31 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 257..279 6/22 (27%)
DbxNP_647677.2 Homeodomain 437..491 CDD:459649 17/79 (22%)
Blue background indicates that the domain is not in the aligned region.

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