Protein Alignment HOXA2 and en

DIOPT Version :10

• Sequence 1: NP_006726.1
• Gene: HOXA2 / 3199
• HGNCID: 5103
• Length: 376
• Species: Homo sapiens
• Sequence 2: NP_523700.2
• Gene: en / 36240
• FlyBaseID: FBgn0000577
• Length: 552
• Species: Drosophila melanogaster
• Alignment Length: 253
• Identity: 72/253 - (28%)
• Similarity: 105/253 - (41%)
• Gaps: 58/253 - (22%)

Human    14 SQPSL---AECLTSFPPV--ADTFQS-SSIKTSTLSHSTLIPPPFEQTIPSLNPGSHPRHGAGG- 71
            :||.|   |..|.|.||.  |.|..| ||:.||:.|.|:    .......|||.....|.||.|
  Fly   315 TQPPLSSSASSLASPPPASNASTISSTSSVATSSSSSSS----GCSSAASSLNSSPSSRLGASGS 375

Human    72 -------RPKPSP---AGSR--------------GSPVPAGALQPPEYPWMKEKKAAKKTALLPA 112
                   :|:|.|   |.||              ||....|.                |..:.||
  Fly   376 GVNASSPQPQPIPPPSAVSRDSGMESSDDTRSETGSTTTEGG----------------KNEMWPA 424

Human   113 ---AAAAATAAATGPACLSHKESLEIADGSGGGSRRLRTAYTNTQLLELEKEFHFNKYLCRPRRV 174
               ....:...::||.....|:..:    .....:|.|||:::.||..|::||:.|:||...||.
  Fly   425 WVYCTRYSDRPSSGPRYRRPKQPKD----KTNDEKRPRTAFSSEQLARLKREFNENRYLTERRRQ 485

Human   175 EIAALLDLTERQVKVWFQNRRMKHKRQTQCKENQNSEGKCKSLEDSEKVEEDEEEKTL 232
            ::::.|.|.|.|:|:||||:|.|.|:.|..|.....:...:.|.:...|...:||:.|
  Fly   486 QLSSELGLNEAQIKIWFQNKRAKIKKSTGSKNPLALQLMAQGLYNHTTVPLTKEEEEL 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXA2	NP_006726.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	42..93		18/75 (24%)
		Antp-type hexapeptide	94..99		0/4 (0%)
		Homeodomain	144..200	CDD:459649	25/55 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	198..229		5/30 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..279
en	NP_523700.2	Homeodomain	455..511	CDD:459649	25/55 (45%)
		Engrail_1_C_sig	512..542	CDD:431338	6/29 (21%)