DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HOXA2 and unpg

DIOPT Version :9

Sequence 1:	NP_006726.1	Gene:	HOXA2 / 3199	HGNCID:	5103	Length:	376	Species:	Homo sapiens
Sequence 2:	NP_477146.1	Gene:	unpg / 35942	FlyBaseID:	FBgn0015561	Length:	485	Species:	Drosophila melanogaster

Alignment Length:	394	Identity:	93/394 - (23%)
Similarity:	135/394 - (34%)	Gaps:	152/394 - (38%)

- Green bases have known domain annotations that are detailed below.

Human    16 PSLAECLTS----FPPVADTFQSSSIKTSTLSHSTLIPPPFEQTIPSLNPGSHPRH-GAGGR--- 72
            |:|...|.:    |.|.|     :.:..:.||:..|.....:..:.||:..:..:| .|.||
  Fly   147 PTLPHPLDTRFLPFNPAA-----AGVAPTDLSYRRLAELMNQDYVHSLSVHARLQHMAAAGRMHE 206

Human    73 ----------PKPSPAGSRGSPVPAGALQPPEYPWMKEKKAAKKTALLPAAAAAATA--AATGPA 125
                      .:|:|..:..||..:|:..|.|                ||.......  ..:|.:
  Fly   207 DQANPGMAQLQEPTPPQAHSSPAKSGSHSPME----------------PALDVGMDEDFECSGDS 255

Human   126 C-----------------------LSHKESLEIADGSG----------GG-------------SR 144
            |                       .::.:|.:.:|..|          ||             ||
  Fly   256 CSDISLTMSPRNYNGEMDKSRNGAYTNSDSEDCSDDEGAQSRHEGGGMGGKDSQGNGSSSNSKSR 320

Human   145 RLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQCKENQN 209
            |.|||:|:.||||||:|||..|||....|.:||..|.|:|.|||:||||||.|.||   .|....
  Fly   321 RRRTAFTSEQLLELEREFHAKKYLSLTERSQIATSLKLSEVQVKIWFQNRRAKWKR---VKAGLT 382

Human   210 SEGKCKSLEDSEKVEEDEEEKTLFEQALSVSGALLEREGYTFQQNALSQQQAPNGHNGDSQSFPV 274
            |.|                               |.|.|.|               :|.....|:
  Fly   383 SHG-------------------------------LGRNGTT---------------SGTKIVVPI 401

Human   275 SPLTSNEKNLKHFQHQSPTVPNCLSTMGQNCGAGLNNDSPEALEVPSLQDFSVFSTDSCLQLSDA 339
             |:..|...::. |||.         :.:.|.:|...|..:.|...::..|..||..     ::|
  Fly   402 -PVHVNRFAVRS-QHQQ---------LEKMCLSGPKPDLRKKLSAEAIGGFEKFSGS-----TNA 450

Human   340 VSPS 343
            .|||
  Fly   451 SSPS 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HOXA2	NP_006726.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..93		14/64 (22%)
		Antp-type hexapeptide	94..99		1/4 (25%)
		Homeobox	147..200	CDD:395001	32/52 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..229		5/30 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..279		3/21 (14%)
unpg	NP_477146.1	Homeobox	324..375	CDD:278475	31/50 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810