Protein Alignment CG2124 and TBRG4

DIOPT Version :10

• Sequence 1: NP_572638.1
• Gene: CG2124 / 31989
• FlyBaseID: FBgn0030217
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001248763.1
• Gene: TBRG4 / 9238
• HGNCID: 17443
• Length: 642
• Species: Homo sapiens
• Alignment Length: 604
• Identity: 111/604 - (18%)
• Similarity: 182/604 - (30%)
• Gaps: 241/604 - (39%)

  Fly    87 LVRHCNRMELKISDSRYEAFTRCFCEQLHRLTDEQL-LGSLSALAELPVPESPKAKNYMEIWNTL 150
            |:.|..|...:|.||             |.|....: :|.||.                .:.|.|
Human   218 LLTHLERRWTEIEDS-------------HTLVTVMMKVGHLSE----------------PLMNRL 253

  Fly   151 DIECCRRIERWSSEQL-----LLVSDAWYRLGLVRIGEY------------VWLAL--------- 189
            :.:|...:|.:...:|     :|.:.:...:.|:|...|            |.|.:
Human   254 EDKCLELVEHFGPNELRKVLVMLAAQSRRSVPLLRAISYHLVQKPFSLTKDVLLDVAYAYGKLSF 318

  Fly   190 ------KKLGRKLRKLPPE----QLVH---SMFLCNLLRRPVFEMF-DFELNLARCVDQMTLSEL 240
                  ::|...|..|.|.    ::.|   |..|...|..|:||.| ...||.|:   .:||..|
Human   319 HQTQVSQRLATDLLSLMPSLTSGEVAHCAKSFALLKWLSLPLFEAFAQHVLNRAQ---DITLPHL 380

  Fly   241 GVMAMGFFKTQ-TPIRNPELLTQLYQRLGSELDTVEDIVLVALLKVLRYSSKLPQVEPLKKMLSA 304
            ..:.:.|.:.. .|.:..:..:.::::||||                     ||.:||      |
Human   381 CSVLLAFARLNFHPDQEDQFFSLVHEKLGSE---------------------LPGLEP------A 418

  Fly   305 LESQVDRVSLLTCLHMALLGCELQTCNDALVERILLRFERELETARLKDMERICLVMALFNITTK 369
            |  |||.|..|         |.||...:|.::.:|
Human   419 L--QVDLVWAL---------CVLQQAREAELQAVL------------------------------ 442

  Fly   370 SGVERRLAERLPDLLRQRIEEILRHPRCFSNCLQFLTMRGVYDLELLGVALEPRFLKHAYPSGLP 434
                                    ||...   :|||..:...|....
Human   443 ------------------------HPEFH---IQFLGGKSQKDQNTF------------------ 462

  Fly   435 GREYFHLDGFARLLGPEYQGALVTEKQRQQMGRNYTQYIP-----DRDGRFKLNNTDRILVEIRD 494
             ::..|::..|.|..|||.|.|:..          :...|     ||    |:....:.|.|
Human   463 -QKLLHINATALLEYPEYSGPLLPA----------SAVAPGPSALDR----KVTPLQKELQE--- 509

  Fly   495 AITMIHRPVTFKHILPQYDR--CDVVLCYDRRQRKALSINGEACQDYSGEIL-----TRKHLLGE 552
                     |.|.:|...|:  .:|...|      ...::.|...|..||.|     ...||...
Human   510 ---------TLKGLLGSADKGSLEVATQY------GWVLDAEVLLDSDGEFLPVRDFVAPHLAQP 559

  Fly   553 RKAADDQLVTVVIVIAGW---NNVIRDKDRFTGQMDMKLRQLRQLGHQPLVIYWHEWRELENSAD 614
            ..:......:..:....|   |...|.|| ..|:..:..|.:...|...:.:.::||.||::...
Human   560 TGSQSPPPGSKRLAFLRWEFPNFNSRSKD-LLGRFVLARRHIVAAGFLIVDVPFYEWLELKSEWQ 623

  Fly   615 RQDFLKRRL-----SQIAK 628
            :..:||.::     .::||
Human   624 KGAYLKDKMRKAVAEELAK 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2124	NP_572638.1	RESC6-like	95..>251	CDD:480594	38/196 (19%)
		RAP	565..622	CDD:214932	14/59 (24%)
TBRG4	NP_001248763.1	TBRG4-like_N	107..355	CDD:467932	29/165 (18%)
		FAST_1	380..451	CDD:461999	26/165 (16%)
		FAST_2	462..547	CDD:462448	24/135 (18%)
		RAP	574..631	CDD:214932	14/57 (25%)