DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2124 and Fastkd2

DIOPT Version :9

Sequence 1:	NP_572638.1	Gene:	CG2124 / 31989	FlyBaseID:	FBgn0030217	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_766010.1	Gene:	Fastkd2 / 75619	MGIID:	1922869	Length:	689	Species:	Mus musculus

Alignment Length:	673	Identity:	127/673 - (18%)
Similarity:	222/673 - (32%)	Gaps:	251/673 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 TTIVSPARIFADRENQF--AHGILMDSLKPYAI--LRPRDSAWQDLPASEGFMRPQPDASAADLY 81
            :.:..|.|:...|...|  .|..:.|....:.:  :....::.:|:...:  :||.|
Mouse    85 SAVFKPDRLLCPRRLSFDAKHSFVSDGTSDHDLKKINFHHTSSEDVFTKK--VRPTP-------- 139

  Fly    82 ADFLGLVRHCNRME-------------------------LKISDS--RYE--------AFTRCFC 111
            .::..|.:.||.:.                         .:||:.  |:|        ||.: .|
Mouse   140 VNYKKLAQECNSLSDVLDTFSKAPTFPGSNYFLAMWIIAKRISEDKRRFERQLMFSHPAFNQ-LC 203

  Fly   112 EQLHR----LTDEQLLGSLSALAELPVPESPKAKNYMEIWNTLDIECC-----RRIERWSSEQLL 167
            ||:.|    :..:.||.||:|:.:|.:|:           |||.::..     .||.......|.
Mouse   204 EQMMREAKIMHYDHLLFSLNAIVKLGIPQ-----------NTLMVQTLLRTIQERINECDERCLS 257

  Fly   168 LVSDAW-----------YRLGL-VRIGEYVW-----------------------------LALKK 191
            ::|.|.           .|.|| :.:.:.||                             .|||:
Mouse   258 ILSTALVSMEPCMNVNALRAGLRILVDQQVWNIKHVFTLQTVMKCIGKDAPSALKKKLEMKALKE 322

  Fly   192 LGR----------------KLRKL-----------------PPEQLVHSMFLCNLLRRPVFEMFD 223
            |||                .||.:                 |.:.|:..:..|..||   ::..|
Mouse   323 LGRFSILNSQHMFEVLAAMDLRSVVLLNECSKVVIDNVHGCPFKVLISILQSCRDLR---YQNED 384

  Fly   224 FELNLARCV----DQMTLSELGVMAMGFFKTQTPIRNPELLTQLYQRLGSELDTVEDIVLVALLK 284
            ...::|..|    |...|.:: :..:..|:| ...|.|.|:.:|.:::..|..::....:|::|.
Mouse   385 LFKSIAEYVATTFDIWKLKQV-IFFLLLFET-LGFRPPGLMDKLMEKVVQEPGSLNVKNIVSILH 447

  Fly   285 VLRYSS-----KLPQVEPLKKMLSALES---QVDRVSLLTCLHMALLGC-----ELQTCNDALVE 336
            |  |||     |:...|.|:.:.|||..   .:...|||..:|..   |     .|...|..:.|
Mouse   448 V--YSSLNHVHKIHNREFLEALASALTGCLHHISSESLLNAVHSF---CMMNYFPLAPINQLIKE 507

  Fly   337 RILLRFERELETARLKDMERICLVMALFNITTK--------------------SGVERRLAERLP 381
            .|:    .||.|:  .|.|:....:.:.|...|                    |....:|||.|.
Mouse   508 NII----NELLTS--GDTEKNIHKLHVLNTCLKLDESTYKSVHIPLPQLPLSASQPNEKLAEVLS 566

  Fly   382 DLL--RQRIEEILRHP---------RCFSNCLQFLTMRGV-----YDLELLGVALEPR---FLKH 427
            .||  ..|....:..|         |..:|..|..:...|     .:::.:.|...|:   .|..
Mouse   567 RLLEGEGRFSRNVPLPHNYHIDFEIRMDTNRTQVFSFSDVDASSATNMQRVAVLCVPKSVYCLNS 631

  Fly   428 AYPSGLPGREYFHLD--GFARLLGPEYQGALVTEKQRQQMGRNYTQYIPDRDGRFKLNNTDRILV 490
            .:|.||...:..||:  ||..:|                                 ::|.:...:
Mouse   632 CHPRGLMAMKIRHLNVMGFHVIL---------------------------------IHNWELKKL 663

  Fly   491 EIRDAITMIHRPVTFKHILPQYD 513
            ::.||:|.:.:.:....:||..|
Mouse   664 KMEDAVTFVRKKIYSDEVLPTAD 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2124	NP_572638.1	RAP	565..622	CDD:214932
Fastkd2	NP_766010.1	FAST_1	443..512	CDD:284217	21/77 (27%)
		FAST_2	<561..596	CDD:285557	9/34 (26%)
		RAP	619..675	CDD:214932	15/88 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21228
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100