DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2124 and fastkd2

DIOPT Version :9

Sequence 1:	NP_572638.1	Gene:	CG2124 / 31989	FlyBaseID:	FBgn0030217	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_021331610.1	Gene:	fastkd2 / 564382	ZFINID:	ZDB-GENE-090313-7	Length:	652	Species:	Danio rerio

Alignment Length:	589	Identity:	116/589 - (19%)
Similarity:	210/589 - (35%)	Gaps:	172/589 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 EQLHRLTDEQLLGSLSALAELPVPESPKAKNYMEIWNTLDIECCRRIERWSSEQLLLVSDAWYRL 176
            |...::|.||....|..:.|.|        .:.|:        |.|:          |||||
Zfish   127 ESTKKMTAEQQRCELQLMFEHP--------GFREV--------CERV----------VSDAW--- 162

  Fly   177 GLVRIGE--YVWLALKKLGRKLRKLPPEQLVHSMFLCNLLRRPVFEMFDFELN----LARCVDQM 235
             .:|..:  |..||:..||..         .|:..:..|||.....:..|:..    ||..:.||
Zfish   163 -RMRCDDLAYTLLAIINLGVS---------QHTRIVQTLLRVVQERLNQFDNRSLSVLAAGIQQM 217

  Fly   236 -------TLSE-LGVMAMGFFKTQTP-IRNPELLTQLYQRLGSELDTVEDIVLVALLKVLRYSSK 291
                   .|.| ||::    .|.:.| |.|..:|..:.:.:|.  ::.:::.:...:|.|..:.:
Zfish   218 ENGNNVQALREALGLL----LKDRVPEISNVVVLQNMMRAMGK--NSPKELKMQLAIKTLSLADE 276

  Fly   292 L--PQVEPLKKMLSALESQVDRVSLLTC---------------LHMALLGC-ELQTCNDALVERI 338
            .  |..:.:...|:|::... :..|..|               |.|.|..| |||..|.:|...|
Zfish   277 FSPPNTQYVFLSLAAMDLNF-KPLLNICSKNIAENVHEFPISRLVMVLKSCYELQYRNYSLFSSI 340

  Fly   339 LLRFERELETARLKDMERICLVMALFN------ITTKSGVERRLAERLPDLLRQRIEEILRHPRC 397
               .|....|..:...:::.|::..|.      :........|:.:: ||.|  .::::|...:.
Zfish   341 ---SEYMTNTFDMWSNKKVILLLLTFEDLYFRPVHLLDAFAERIIQK-PDSL--TLKDLLSVLKV 399

  Fly   398 FSNCLQFLTMRGVYDLELLGVALEPRFLKHAYPSGLPGREYFHLDGFARLLGPEYQGALVTEKQR 462
            ||.....|..|....|:.:...|| .:|....||.|....|:       |...|:...::.:|..
Zfish   400 FSMLNHDLKERKTEFLDCITEVLE-SYLPKMTPSELLKVNYY-------LALMEHFHQMLLDKLM 456

  Fly   463 QQMGRNYTQYIPDRDGRFKLNNTDRILVEIRDAITMIHRPVTFKHILPQYDRCDVVLCYDRRQ-- 525
            ||            :...:|..||:..:::   :..:|             ..|:.|..|:.|
Zfish   457 QQ------------ETLEQLLQTDKPSIKV---LRWLH-------------TIDLCLQLDKPQLP 493

  Fly   526 ----RKALSINGEACQDYSG-EILTR-KHLLGERKAAD----------DQLVT------------ 562
                .|.|:|...|.:..:. |:|:. :.::|.....|          |.::|
Zfish   494 SFTSSKPLNITVPAFEATANQEMLSAVRSIVGTHAVQDSVLEQSIYFIDCVITLPGEKVETCGLH 558

  Fly   563 -----------VVIVIAGWNNVIRDKDRFTGQMDMKLRQLRQLGHQPLVIYWHEWRELENSADRQ 616
                       :.::.|..|:...........:.||||.|.:||:||:::..:|.    ||...:
Zfish   559 EDCGSPECNQRIAVICAQPNSFCFGTTHPRASLVMKLRHLEKLGYQPVLVPINEL----NSKTEE 619

  Fly   617 DFLK 620
            :.:|
Zfish   620 EKIK 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2124	NP_572638.1	RAP	565..622	CDD:214932	15/56 (27%)
fastkd2	XP_021331610.1	FAST_1	394..463	CDD:310980	18/88 (20%)
fastkd2	XP_021331610.1	RAP	577..628	CDD:214932	14/51 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21228
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100