Protein Alignment CG2124 and FASTKD2

DIOPT Version :10

• Sequence 1: NP_572638.1
• Gene: CG2124 / 31989
• FlyBaseID: FBgn0030217
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_055744.2
• Gene: FASTKD2 / 22868
• HGNCID: 29160
• Length: 710
• Species: Homo sapiens
• Alignment Length: 634
• Identity: 125/634 - (19%)
• Similarity: 212/634 - (33%)
• Gaps: 211/634 - (33%)

  Fly   115 HRLTDEQLLGSLSALAEL-----PVPESPKAKNYMEIWNTLDIECCRRIERWSSEQ------LLL 168
            :|::..:|....::|:::     ..|..|.:..:..:|..        .:|.|.:|      |:.
Human   152 NRISSRKLSEECNSLSDVLDAFSKAPTFPSSNYFTAMWTI--------AKRLSDDQKRFEKRLMF 208

  Fly   169 VSDAW-----YRLGLVRIGEYVWL-----ALKKLGRKLRKLPPEQLVHSMFLCNLLRRPVFEMFD 223
            ...|:     :.:...:|.:|.:|     |:.|||          :..:..|...|.|...|
Human   209 SHPAFNQLCEHMMREAKIMQYKYLLFSLHAIVKLG----------IPQNTILVQTLLRVTQE--- 260

  Fly   224 FELNLARCVDQMTLSELGVMAMGFFKTQTPIRNPELLTQLYQRL-GSELDTVEDI-VLVALLKVL 286
               .:..| |::.||.|..:    .:...|.:|..:|...::.| ..::..:||: .|..::|.:
Human   261 ---RINEC-DEICLSVLSTV----LEAMEPCKNVHVLRTGFRILVDQQVWKIEDVFTLQVVMKCI 317

  Fly   287 RYSSKLPQVEPLKKML--SALESQVDRVSLLTCLHM------------ALL------------GC 325
            ...:.:    .||:.|  .||. ::||.|:|...||            .||            ||
Human   318 GKDAPI----ALKRKLEMKALR-ELDRFSVLNSQHMFEVLAAMNHRSLILLDECSKVVLDNIHGC 377

  Fly   326 E-------LQTCND----------ALVERILLRFERELETARLKDMERICLVMALFNITTKSGVE 373
            .       ||:|.|          .|.:.:...|:       :....::..::.||
Human   378 PLRIMINILQSCKDLQYHNLDLFKGLADYVAATFD-------IWKFRKVLFILILF--------- 426

  Fly   374 RRLAER---LPDLLRQRIEEILRHPRCFS--NCLQFL----TMRGVYD-------LELLGVAL-- 420
            ..|..|   |.||..:||.|   .|...:  |.|..|    ::..||.       :|::..||
Human   427 ENLGFRPVGLMDLFMKRIVE---DPESLNMKNILSILHTYSSLNHVYKCQNKEQFVEVMASALTG 488

  Fly   421 ------EPRFLKHAYPSGLPGREYFHLDGFARLLGPEYQGALVTEKQRQQMGRNYTQYIPDRDGR 479
                  ....|...|...|  ..||.|..|.:||..:....|:|.              .|....
Human   489 YLHTISSENLLDAVYSFCL--MNYFPLAPFNQLLQKDIISELLTS--------------DDMKNA 537

  Fly   480 FKLNNTDRIL-----VEIRD---AITMIHRPVTFKHI-----------------------LPQYD 513
            :||:..|..|     |.:||   ::..:.|.:...|.                       ||...
Human   538 YKLHTLDTCLKLDDTVYLRDIALSLPQLPRELPSSHTNAKVAEVLSSLLGGEGHFSKDVHLPHNY 602

  Fly   514 RCDVVLCYDRRQRKALSINGEACQDYSGEILTRKHLLGERKAADDQLVTVVIVIAGWNNVIRDKD 578
            ..|..:..|..:.:.|.::.                :....|.|.|.|.|:.|......:.....
Human   603 HIDFEIRMDTNRNQVLPLSD----------------VDTTSATDIQRVAVLCVSRSAYCLGSSHP 651

  Fly   579 RFTGQMDMKLRQLRQLG-HQPLVIYWHEWRELENSADRQDFLKRRLSQI 626
            |  |.:.||:|.|..:| |..||..| |..:|| ..|...|||.::..:
Human   652 R--GFLAMKMRHLNAMGFHVILVNNW-EMDKLE-MEDAVTFLKTKIYSV 696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2124	NP_572638.1	RESC6-like	95..>251	CDD:480594	27/156 (17%)
		RAP	565..622	CDD:214932	19/57 (33%)
FASTKD2	NP_055744.2	RESC6-like	181..407	CDD:480594	50/259 (19%)
		FAST_1	456..529	CDD:461999	16/74 (22%)
		FAST_2	<578..619	CDD:462448	4/40 (10%)
		RAP	636..692	CDD:214932	20/59 (34%)