DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spri and RIN1

DIOPT Version :9

Sequence 1:	NP_001259418.1	Gene:	spri / 31987	FlyBaseID:	FBgn0085443	Length:	2043	Species:	Drosophila melanogaster
Sequence 2:	NP_004283.2	Gene:	RIN1 / 9610	HGNCID:	18749	Length:	783	Species:	Homo sapiens

Alignment Length:	1346	Identity:	236/1346 - (17%)
Similarity:	346/1346 - (25%)	Gaps:	711/1346 - (52%)

- Green bases have known domain annotations that are detailed below.

  Fly   714 LGLMERLLVTHPMWFLPGIQRSGAVHLLQGKEEGTFIVRGSSQPNTMAVSVRLPQDTGPYI--EH 776
            :.|.||||:|.|:|.......:.|:|:|:.:..|||:||.|:.....|:.:|||:.:||..  .|
Human    56 VSLRERLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSH 120

  Fly   777 YLIQSHDNVLSLESSRFTFGSIPSLIAHYAQCCDELPVQLMLPRVLREANNRKKLSSLALLGQEF 841
            |:::|...| |||.|...|..:..||..|....|.|.:.|.|||.:..|...|:|.:::.||.||
Human   121 YILESPGGV-SLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHLGIEF 184

  Fly   842 W-SYVSSPALLGPLTPSVAPSKDQQLLDAKSPLSLTETSGLGTATFFSDTVSKPPPTGAPPLPGG 905
            | |.::..|..||....|.|.     |.|:||..|.:
Human   185 WSSSLNIKAQRGPAGGPVLPQ-----LKARSPQELDQ---------------------------- 216

  Fly   906 GLFSPTGSGQLLGFFSQAGTPSDTTNSSLSSFTTSGGQHMQLLSPNSVDSVILTMSPVDNPGHYL 970
                  |:|..|.||                                            ||  ..
Human   217 ------GTGAALCFF--------------------------------------------NP--LF 229

  Fly   971 PGSTGAPMAPLCPSVVDQQLSTFKVAQTAPEVDQVRPQRPKPPNTLNLKPPAPPLRWSKPHSPDQ 1035
            ||..|       |:..::...:|||        :|..:...|     |.|||.|
Human   230 PGDLG-------PTKREKFKRSFKV--------RVSTETSSP-----LSPPAVP----------- 263

  Fly  1036 NGSANGNFTVTTTVTFSMENGGGGGSGPTVGNGNGKFVEVTTPAASNPFNALLNGQASTFQTFAK 1100

Human   264 ----------------------------------------------------------------- 263

  Fly  1101 RLSPEGECKDTLSSQGSSSNDSRWPPPARKLLTSPMTPLTPSGGSSSSGGKSRKSRAGKESQHYK 1165
                                    |||         .|:.|
Human   264 ------------------------PPP---------VPVLP------------------------ 271

  Fly  1166 ESDILESPPMQYCASALSDKISDYEDVWSHDPSDRASLLTSFRPALDTVGGVMNRRPDLLAETPS 1230
                                                             |.|
Human   272 -------------------------------------------------GAV------------- 274

  Fly  1231 TPTPTQQSHLTPCEEETTATPNESSSQSLLQFSGDVPARSRAGLLLPNLSGQVPPVAMTKSMTAA 1295
               |:|...|.||:              ||:
Human   275 ---PSQTERLPPCQ--------------LLR---------------------------------- 288

  Fly  1296 EDDGGDTTPTAEGQANGASRSKQGSPFYAEPADALRQAGLTSAATAILRRQHRSQMLHASQRHSE 1360
                                 ::.|..|..||
Human   289 ---------------------RESSVGYRVPA--------------------------------- 299

  Fly  1361 PLKAGFGGSGNGAMLQPSDLEKLAGSLDELKPKPKVSQQQQQSQQQQQPTKRARNRIDHWQLDSS 1425
                   |||      ||           |.|.|.:.:
Human   300 -------GSG------PS-----------LPPMPSLQE--------------------------- 313

  Fly  1426 WEFMAKQDTGSHAGGDYDTAAIDWQEKENSLGRDSRADGQGKKRTLTIHQIIANRLPDLNLPELV 1490
                                                                            |
Human   314 ----------------------------------------------------------------V 314

  Fly  1491 RCSTPPQTAALQPHVLGQDKAGVGCDGSQKSFQSQIGCRLSSYDNVFCQNSFGGIDSAQSDDGTI 1555
            .|.:|..:          ::.||  .||:                                 |:.
Human   315 DCGSPSSS----------EEEGV--PGSR---------------------------------GSP 334

  Fly  1556 FSEPWDSSQWDTFLPHDDATINSDTIHLSKCRPALSEDDTIVEELQSTKDGSNGSCNQDTLKANR 1620
            .:.|                      ||.:.||.|             :..|...|   :|.|..
Human   335 ATSP----------------------HLGRRRPLL-------------RSMSAAFC---SLLAPE 361

  Fly  1621 NGAGHHKLNNGNGNGKANNRPKVATILRNPSMRDREVLCHPRNKMSIQSSGPGDSLRAYTLQLAQ 1685
            ...|                 :.|..|    |:||..           ::|          ||.|
Human   362 RQVG-----------------RAAAAL----MQDRHT-----------AAG----------QLVQ 384

  Fly  1686 DPSSTFARNIENFICCTKESREAAPQVVMRNMRQFMSGMKNYLVKHGEGKFHAELETARARLKSD 1750
            |             ..|:......|| .::.:||.:|..:..|               .|.|..:
Human   385 D-------------LLTQVRAGPEPQ-ELQGIRQALSRARAML---------------SAELGPE 420

  Fly  1751 EFLN---LDAMLETVMHQLVVLPLREHLYGIFVDHYQRSEDIQLLAQNVRYACEREAADFGIRPT 1812
            :.|:   |:.:||..:|..|:.|||..|.............:..||:.:|.|..:....||..
Human   421 KLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGLRLARAQGPGAFGSH-- 483

  Fly  1813 VTPPSQAALRLIANLLWRLQEAELPLDKLELFLCVISTVFDATGCPRGQQLGADDFLPVLVYVVA 1877
            ::.||...|..:...|.:|.....|..:::..|.....::.|.....|:..|||:|||:|..|:|
Human   484 LSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEGEGAGADEFLPLLSLVLA 548

  Fly  1878 KCGFVGAEIEAEFMWGLLQPTLLNGEPGYYLTALCSAVQVLK------TFMASEGESGSGSLD-W 1935
            .|......:|||:|..||:|:||.||.|||||:|.:::.:|.      |...|..:....||. |
Human   549 HCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSGLGQAHTLPLSPVQELRRSLSLW 613

  Fly  1936 RSSCLPA--C-SSVLRVIIPDECNGSLQTRTLPVRPHTTTREVCRIIAHKARITNPQDYALFKLV 1997
            ....|||  | ..:|||...|..:| ..::||.|.|..:...:.::.|.|.|:|.|..:.||...
Human   614 EQRRLPATHCFQHLLRVAYQDPSSG-CTSKTLAVPPEASIATLNQLCATKFRVTQPNTFGLFLYK 677

  Fly  1998 D-GEETLLTDAECPQDA---RLAAKGKHCMLAYKRIDAKIAWPTAQ 2039
            : |...|      |..|   ||...|   .|.|:|.:    ||..|
Human   678 EQGYHRL------PPGALAHRLPTTG---YLVYRRAE----WPETQ 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spri	NP_001259418.1	SH2	716..813	CDD:301589	36/98 (37%)
		VPS9	1821..1922	CDD:280383	36/106 (34%)
		UBQ	1946..2026	CDD:294102	24/83 (29%)
RIN1	NP_004283.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53
		SH2	58..158	CDD:326550	37/100 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..282		15/234 (6%)
		Ras and 14-3-3 protein binding region	294..727		140/735 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	295..342		22/261 (8%)
		VPS9	489..607	CDD:128469	37/117 (32%)
		UBQ	627..704	CDD:320785	25/86 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	709..783		1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149885
Domainoid	1	1.000	76	1.000	Domainoid score	I8962
eggNOG	1	0.900	-	-		E1_KOG2320
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001291
OrthoInspector	1	1.000	-	-		otm41965
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23101
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3144
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.870