Protein Alignment spri and VPS9D1

DIOPT Version :10

• Sequence 1: NP_001259418.1
• Gene: spri / 31987
• FlyBaseID: FBgn0085443
• Length: 2043
• Species: Drosophila melanogaster
• Sequence 2: XP_047290886.1
• Gene: VPS9D1 / 9605
• HGNCID: 13526
• Length: 645
• Species: Homo sapiens
• Alignment Length: 761
• Identity: 155/761 - (20%)
• Similarity: 240/761 - (31%)
• Gaps: 262/761 - (34%)

  Fly  1244 EEETT-----ATPNESS-----SQSLLQFSGDVPARSRAGLLLPNLSGQVP-PVAMTKSMTAAED 1297
            |.|||     ..|.::|     :|..|:.:....|:.....|.|.:....| |....:......|
Human    53 EVETTKEAGETVPPDTSKMLKLAQQCLERAQSTAAKLGKTRLKPTMPAAAPIPQPAGRHRRVYSD 117

  Fly  1298 DGGDTTPTAEGQ-------ANGASRSKQGSPFYAEPADALRQAGLTSAATAILRRQHRSQMLHAS 1355
            :||..:|....:       |...|..|:.:|.  |.| :|:...|.:|..|.:.|...||   |.
Human   118 EGGKLSPFLPPEIFQKLQGAESQSCKKELTPL--EEA-SLQNQKLKAAYEARMARLDPSQ---AM 176

  Fly  1356 QRHSEPLKAGFGGSGNGAMLQPSDLEKLAGSLDELKPKPKVSQQQQQSQQQQQPTKRAR-----N 1415
            |:.|..|.           ||...:|.|.           :::.::::.|::...:|.|     |
Human   177 QKTSLTLS-----------LQRQMMENLV-----------IAKAREETLQRKMEERRLRLQEAAN 219

  Fly  1416 R---------------------IDHWQLDSSWEFMAKQDTGSHAGGDYDTAAIDWQEKENSLGRD 1459
            |                     |..::.|..|.        .|           |:.|.
Human   220 RRFCSQVALTPEEREQRALYAAILEYEQDHDWP--------KH-----------WKAKL------ 259

  Fly  1460 SRADGQGKKRTLTIHQIIANRLPDLNLPELVR---CSTPPQTAALQPHVLGQDKAGVGC------ 1515
            .|..|.....|..:..:::  |||..:.:|:|   ||.   .:||.|.|........||
Human   260 KRNPGDLSLVTSLVSHLLS--LPDHPIAQLLRRLQCSV---YSALYPAVSRAAAPAPGCCPPTPN 319

  Fly  1516 DGSQKSFQSQ-IGCRLSSYDNVFCQNSFGGIDSAQSDDGTIFSEPWDSSQWDTFLPHDDATINSD 1579
            .||::...|| :.|.||                  ..:.:....|.||.......|   ..:.|.
Human   320 PGSRRLRPSQSLHCMLS------------------PPEPSAAPRPQDSPPTPPLQP---GPVGSP 363

  Fly  1580 TIHLSKCRPALSEDDTIVEELQ-----STKDGSNGSCNQDTLKANRNGAGHHKLNNGNGNGKANN 1639
            : .|......|.:.|:..|:|:     |.:.| .|...|...:..:......:::|..|......
Human   364 S-PLGDTASGLPDKDSSFEDLEQFLGTSERQG-RGRGVQPEPQLQQLKTAVEEIHNAVGEEPLWT 426

  Fly  1640 RPKVATILRNPSMRDREVLCHPRNKMSIQSSGPGDSLRAYTLQLAQDPSSTFARNIENFICCTKE 1704
            .|  |..|                         .|.|.:.|| ||.:..:| |.:.:..:.|.:|
Human   427 SP--ALFL-------------------------ADRLLSLTL-LAFEGLNT-AASKDRCLACIEE 462

  Fly  1705 SREAAPQVVMRNMRQFMSGMKNYLVKHGEGKFHAELETARARLKSDEFLNLDAMLETVMHQLVVL 1769
                          .|.|.:...|:     ..:..:..||           :|.|...|
Human   463 --------------PFFSPLWPLLL-----ALYRSVHRAR-----------EAALSRSM------ 491

  Fly  1770 PLREHLY--------GIFVDHYQRSEDIQLLAQNVRYACEREAADFGIRPTVTPPSQAALRLIAN 1826
                .||        ||         ..:||.||.    |.:.|      |..|...||..|...
Human   492 ----ELYRNAPPTAIGI---------PTKLLPQNP----EAKGA------TGYPYCAAAQELGLL 533

  Fly  1827 LLWRLQEAELPLDKLELFLCVIST-----VFDATGCPRGQ-------------QLGADDFLPVLV 1873
            :|     ...|..|||   |::.|     |.....||..:             .:||||.||:|.
Human   534 VL-----ESCPQKKLE---CIVRTLRIICVCAEDYCPTPEATPQAGPPPIAAAAIGADDLLPILS 590

  Fly  1874 YVVAKCGFVGAEIEAEFMWGLLQPTLLNGEPGYYLTALCSAVQVLK 1919
            :||.:.|......|...:...:....|.||.||.||:|.||:..::
Human   591 FVVLRSGLPQLVSECAALEEFIHEGYLIGEEGYCLTSLQSALSYVE 636

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spri	NP_001259418.1	SH2	716..813	CDD:472789
		VPS9	1824..1922	CDD:460489	31/114 (27%)
		RA_Rin	1946..2030	CDD:340474
VPS9D1	XP_047290886.1	VPS9	523..638	CDD:460489	34/122 (28%)