Protein Alignment spri and vps9d1

DIOPT Version :10

• Sequence 1: NP_001259418.1
• Gene: spri / 31987
• FlyBaseID: FBgn0085443
• Length: 2043
• Species: Drosophila melanogaster
• Sequence 2: NP_001072861.1
• Gene: vps9d1 / 780322
• XenbaseID: XB-GENE-1014900
• Length: 640
• Species: Xenopus tropicalis
• Alignment Length: 754
• Identity: 140/754 - (18%)
• Similarity: 236/754 - (31%)
• Gaps: 273/754 - (36%)

  Fly  1209 PALDTVGGVMNRRPDLLAETPSTPTPTQQSHLTPCEEETTATPNESSSQSLLQFSGDVPARSRAG 1273
            |...:.....:|...|.:.:||:      ||...|.:||         |.|..|
 Frog   109 PHASSAASATSRLSSLSSISPSS------SHRRTCSDET---------QKLSSF----------- 147

  Fly  1274 LLLPNLSGQVPPVAMTKSMTAAEDDGG--DTTPTAEGQANGAS-------RSKQGSPFYAEPADA 1329
                      ||..:.:.:.|||...|  :.||..|.......       |..:.:|
 Frog   148 ----------PPPEIFQMLLAAEVQRGKKELTPLEEASIQNQKLKAAYEVRLARLNP-------- 194

  Fly  1330 LRQAGLTSAATAILRRQHRSQMLHASQRHSEPLKAGFGGSGNGAMLQPSDLEKLAGSLDELKPKP 1394
             |||...::.|..|:||....::.|..|.                      |.|
 Frog   195 -RQAAAKTSLTLSLQRQMMENLVIAKARE----------------------ETL----------- 225

  Fly  1395 KVSQQQQQSQQQQQPTKRARNRIDHWQLDSSWEFMAKQDTGSHAGGDYDTAAIDWQEKENSLGRD 1459
                 |:::::::|..|...||......|.:.| |.:|..       ..||.:::::
 Frog   226 -----QRKAEERRQRLKEESNRRFSLNTDMTPE-MEEQRV-------LYTAVLEYEQ-------- 269

  Fly  1460 SRADGQGKKRTLTIHQIIANRLPDLNLPELVRC---STPPQTAALQPHVLGQDKAGVGCDGSQKS 1521
               |.:..||   ..|.|.....|.:|.....|   |||                    |.....
 Frog   270 ---DHEWPKR---FKQKIKGNPADTDLVSSFMCQVLSTP--------------------DHPVSK 308

  Fly  1522 FQSQIGCRLSSYDNVFCQNSFGGIDSAQSDDGTIFSEPWDSSQWDTFLPHDDATINSDTIHLSKC 1586
            ..:.:.|::  |..|:               ..|..:|         :.|:..|  ||..|.|..
 Frog   309 LLTNLQCQI--YSRVY---------------PVIIKDP---------MEHNHGT--SDVFHQSLP 345

  Fly  1587 RPALSEDDTIVEELQSTKDGSNGSCNQDTLKANRNGAGHHKLNNGNG--NGKANNRPKVATILRN 1649
            ..||....:..:.|:|::   :..|....|:.:..    |.|:.|.|  :.:|.|
 Frog   346 TDALPSPASNSQHLKSSQ---SLQCLPSLLQPSVK----HSLSTGEGFEHLEATN---------- 393

  Fly  1650 PSMRDREVLCHPRNKMSIQSSGPGDSLRAYTLQLAQDPSSTFARNIENFICCTKESREAAPQVVM 1714
                |:.:           ..||.|..|..:.:           ::|:.:..|:.|        :
 Frog   394 ----DKLI-----------DKGPCDKERENSFE-----------DLEHCLSPTEYS--------I 424

  Fly  1715 RNMRQFMSGMKNYLVKHGEGKFHAELETARARLKSDEFLNL-------DAMLETV---------- 1762
            .|.....|.:...:||        |:..|:..|.|...|:|       |..:|.:
 Frog   425 GNASLTASALLKAVVK--------EIHNAKDLLLSASLLDLPPNTIFKDVCVECIDESFFPPIWP 481

  Fly  1763 ----MHQLVVLPLREHLYGIFVDHYQRSEDIQLLAQNVRYACEREAADFGIRPTVTPPSQAALRL 1823
                :::.|:|...|.|......:...::.:..:.|.:            ....|..|.:||:..
 Frog   482 ALLALYRHVLLAREESLLQAMKSYRDNAQSVVGVPQKL------------FPEEVEQPYKAAVEE 534

  Fly  1824 IANLLWRLQEAELPLDKLELFLCVISTVFDATGC-------PRGQQLGADDFLPVLVYVVAKCGF 1881
            |.:|...    ..|..|:|   |::.|:.....|       |....:||||.||:|.:||.|...
 Frog   535 IGHLPLH----HTPQRKME---CIVRTMRVICECAEEYCTAPGTSAIGADDLLPILAFVVLKTQM 592

  Fly  1882 VGAEIEAEFMWGLLQPTLLNGEPGYYLTALCSAVQVLKT 1920
            .....|...:...:....|.||.||.||:|.||:..:::
 Frog   593 PQLLSECAALEEFIHEGYLIGEDGYCLTSLLSALSYVES 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spri	NP_001259418.1	SH2	716..813	CDD:472789
		VPS9	1824..1922	CDD:460489	30/104 (29%)
		RA_Rin	1946..2030	CDD:340474
vps9d1	NP_001072861.1	VPS9	528..632	CDD:460489	32/111 (29%)