Protein Alignment spri and Rin2

DIOPT Version :10

• Sequence 1: NP_001259418.1
• Gene: spri / 31987
• FlyBaseID: FBgn0085443
• Length: 2043
• Species: Drosophila melanogaster
• Sequence 2: NP_001393437.1
• Gene: Rin2 / 74030
• MGIID: 1921280
• Length: 903
• Species: Mus musculus
• Alignment Length: 1404
• Identity: 283/1404 - (20%)
• Similarity: 435/1404 - (30%)
• Gaps: 582/1404 - (41%)

  Fly   660 ELSQSRTSLVSSSEGGILAEGETSSEDDEEEPVEAED-EGEESSRDSSDNSPPCDLGLMERLLVT 723
            ||.:.......|.|.| |...||.|....::...:|| :|:...|||..:|....|.:::|||.|
Mouse    30 ELKREMVQTDISRENG-LEPSETHSMVRHKDGGYSEDKDGKTCPRDSGYDSLSNRLSILDRLLHT 93

  Fly   724 HPMWFLPGIQRSGAVHLLQGKEEGTFIVRGSSQPNTMAVSVRLPQDTGPYIEHYLIQSHDNVLSL 788
            ||:|....:....|..:||.:..|.|:||.||:.....:|:|||.:.|..::.:.|:......||
Mouse    94 HPIWLQLSLSEEEAAEVLQAQPPGIFLVRKSSKMQKKVLSLRLPCEFGAPLKEFTIKESTYTFSL 158

  Fly   789 ESSRFTFGSIPSLIAHYAQCCDELPVQLMLPRVLREANNRKKLSSLALLGQEFWSYVSSPALLGP 853
            |.|..:|..:..|||.|....|.||..|.||..:..|....:|..||.||..|||
Mouse   159 EGSGISFADLFRLIAFYCISRDVLPFTLKLPYAISTAKTESQLEELAQLGLNFWS---------- 213

  Fly   854 LTPSVAPSKDQQLLDAKSPLSLTETSGLGTATFFSDTVSKPPPTGAPPLPGGGLFSPTGSGQLL- 917
               |.|.:|         ||                  :.|||  ..|||..|: .|....||.
Mouse   214 ---SSADNK---------PL------------------NSPPP--HRPLPSAGI-CPASLRQLCL 245

  Fly   918 --GFFS-QAGTPSD----TTNSSLSSFTTSGGQHMQLLSPNSVDSVILTMSPVDNPGHYLPGSTG 975
              |..| :..|||:    .||.:|....
Mouse   246 INGVHSIKTRTPSELECSQTNGALCFIN------------------------------------- 273

  Fly   976 APMAPLCPSVVDQQLSTFKVAQTAPEVDQVRPQRPKPPNTLNLKPPAPPLRWSKPHSPDQNGSAN 1040
                ||...|..|.|||                .||.|:|               .:|:.||:..
Mouse   274 ----PLFLKVHSQDLST----------------GPKRPST---------------RTPNANGTER 303

  Fly  1041 GNFTVTTTVTFSMENGGGGGSGPTVGNGNGKFVEVTTPAASNPFNALLNGQASTFQTFAKRLSPE 1105
                                                                             
Mouse   304 ----------------------------------------------------------------- 303

  Fly  1106 GECKDTLSSQGSSSNDSRWPPPARKLLTSPMTPLTPSGGSSSSGGKSRKSRAGKESQHYKESDIL 1170
                            .|.|||
Mouse   304 ----------------PRSPPP------------------------------------------- 309

  Fly  1171 ESPPMQYCASALSDKISDYEDVWSHDPSDRASLLTSFRPALDTVGGVMNRRPDLLAETPSTPTPT 1235
            ..||                                  ||:::    ::..|.|....|.|..|.
Mouse   310 RPPP----------------------------------PAINS----LHTSPGLSRTEPQTSMPE 336

  Fly  1236 QQSHLTPCEEETTATPNESSSQSLLQFSGDVPARSRAGLLLPNLSGQVPPVAMTKSMTAAEDDGG 1300
            ..:|            ::..:.:||   |..|.             .:||..:
Mouse   337 TVNH------------SKHGNVALL---GTKPT-------------PIPPPRL------------ 361

  Fly  1301 DTTPTAEGQANGASRSKQGSPFYAEPADALRQAGLTSAATAILRRQHRSQMLHASQRHSEPLKAG 1365
                           .||.|...||          :||.|...||         ..|.||
Mouse   362 ---------------KKQASFLEAE----------SSAKTLTARR---------PSRRSE----- 387

  Fly  1366 FGGSGNGAMLQPSDLEKLAGSLDELKPKPKVSQQQQQSQQQQQPTKRARNRIDHWQLDSSWEFMA 1430
                                      |:|::                              |...
Mouse   388 --------------------------PEPEL------------------------------ELEL 396

  Fly  1431 KQDTGSHAGGDYDTAAIDWQEKENSLGRDSRADGQGKKRTLTIHQIIANRLPDLNLPELVRCSTP 1495
            :..|..||||              :..||:..|              ..|.|            |
Mouse   397 EMGTAGHAGG--------------APPRDAPGD--------------CTRAP------------P 421

  Fly  1496 PQTAALQPHVLGQDKAGVGCDGSQKSFQSQIGCRLSSYDNVFCQNSFGGIDSAQSDDGTIFSEPW 1560
            |          |.:.....|.|:::        |||
Mouse   422 P----------GSESQPPPCHGARQ--------RLS----------------------------- 439

  Fly  1561 DSSQWDTFLPHDDATINSDTIHLSKCRPALS-EDDTIVEELQSTKDGSNGSCNQDTLKANRNGAG 1624
                 |..|    :|.:||::...:..|... |.||     .|:.:...|..:|:|:..
Mouse   440 -----DMSL----STSSSDSLEFDRSMPLYGYEADT-----TSSLEDYEGESDQETMAP------ 484

  Fly  1625 HHKLNNGNGNGKANNRPKVATILRNPSMRDREVLCHPRNKMS-IQSS--GPGDSLRAYTLQLAQD 1686
                            |..:...||.|....:::.....||| :.||  .|...:.....:|::|
Mouse   485 ----------------PIKSKKKRNSSFVLPKLVKSQLRKMSGVFSSFMTPEKRMVRRIAELSRD 533

  Fly  1687 PSSTFARNIENFICCTKESRE--AAPQVVMRNMRQFMSGMKNYLVKHGEGKFHAELETARARLKS 1749
            ..:.|...:::::...||::|  .:...:::.:||||:.:||||.:      .:||:.....|..
Mouse   534 KCTYFGCLVQDYVSFLKENKECHVSSTDMLQTIRQFMTQVKNYLSQ------SSELDPPIESLIP 592

  Fly  1750 DEFLNLDAMLETVMHQLVVLPLREHLYGIFVDHYQRSEDIQLLAQNVRYACEREAADFGI-RPTV 1813
            ::  .:|.:||..||:.::.||:.|:..:..|.:......:.|.:|::...:|...:.|: .||
Mouse   593 ED--QIDVVLEKAMHKCILKPLKGHVEAMLKDFHTADGSWKQLKENLQLVRQRNPQELGVFAPT- 654

  Fly  1814 TPPSQAALRLIANLLWRLQEAELPLDKLELFLCVISTVFDATGCPRGQQLGADDFLPVLVYVVAK 1878
              |....|..|......:|:...|..|:.|.|.|...::.......|:..|||||||||.||:|:
Mouse   655 --PDLMELEKIKLKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQ 717

  Fly  1879 CGFVGAEIEAEFMWGLLQPTLLNGEPGYYLTALCSAVQVLKTFMASE------GESGSGSLDWR- 1936
            |..:..:.|.|:|..||.|:||:||.|||||:...|:.::|.|...:      .|:......|.
Mouse   718 CDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSEARDTLRQWHK 782

  Fly  1937 ----SSCLPAC---SSVLRVIIPDECNGSLQTRTLPVRPHTTTREVCRIIAHKARITNPQDYALF 1994
                :..:|:.   .:.|||.. .|.|.....:||.|||:.||.:||::.|.|.::.:|::|:||
Mouse   783 RRTTNRTIPSVDDFQNYLRVAF-QEVNSGCTGKTLLVRPYITTEDVCQLCAEKFKVEDPEEYSLF 846

  Fly  1995 KLVDGEETLLTDAECPQDARLAAKGK---HCM-LAYKRI 2029
            ..||.....|.:...||..:.....:   |.. ..||||
Mouse   847 LFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRI 885

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spri	NP_001259418.1	SH2	716..813	CDD:472789	32/96 (33%)
		VPS9	1824..1922	CDD:460489	38/97 (39%)
		RA_Rin	1946..2030	CDD:340474	30/88 (34%)
Rin2	NP_001393437.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	44..73		8/29 (28%)
		SH2_RIN2	86..185	CDD:198257	34/98 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..455		70/596 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	471..491		4/41 (10%)
		Interaction with RAB5B. /evidence=ECO:0000250	506..775		80/279 (29%)
		VPS9	659..775	CDD:128469	41/115 (36%)
		RA_Rin2	796..886	CDD:340548	30/91 (33%)