Protein Alignment spri and Vps9d1

DIOPT Version :10

• Sequence 1: NP_001259418.1
• Gene: spri / 31987
• FlyBaseID: FBgn0085443
• Length: 2043
• Species: Drosophila melanogaster
• Sequence 2: NP_001297590.1
• Gene: Vps9d1 / 72325
• MGIID: 1914143
• Length: 650
• Species: Mus musculus
• Alignment Length: 878
• Identity: 157/878 - (17%)
• Similarity: 262/878 - (29%)
• Gaps: 331/878 - (37%)

  Fly  1145 SSSSGGKSRKSRAGKESQHYKESDILESP---------PMQYCASALSDKISDYEDVWSHDPSDR 1200
            ::..||......|.|.:....|.|....|         .:.|.:..|.:.:.:..:.....|.:.
Mouse     4 AAGDGGAKPLQSAMKLANKAIELDTGNRPREAYVEYLRSIHYISQVLLEDVENTTEAGETVPPET 68

  Fly  1201 ASLLTSFRPALD------TVGGVMNRRPDLLAETPSTPTPTQQSHLTPCEEETTATPNESSSQSL 1259
            :.:|......|:      |..|.:..:|.:.| .|.||.||.: |...|.:|
Mouse    69 SKMLKLAEQCLERAQSTATKLGRICLKPAVPA-APPTPLPTSR-HRRVCSDE------------- 118

  Fly  1260 LQFSGDVPARSRAGLLLPNLSGQVPPVAMTKSMTA-AEDDGGDTTPTAEGQANGASRSKQGSPFY 1323
                        .|.|.|.|    ||....|...| :::...:.||..:.   .....|..:.:.
Mouse   119 ------------GGKLSPFL----PPEIFQKLQVAESQNSKKELTPLEKA---SLQNQKLRATYE 164

  Fly  1324 A-----EPADALRQAGLTSAATAILRRQHRSQMLHASQRHSEPLKAGFGGSGNGAMLQPSDLEKL 1383
            |     :|:.|:::..||.:    |:||....::.|..|.                      |.|
Mouse   165 ARMARLDPSQAMQKTSLTLS----LQRQMMENLVIAKARE----------------------ETL 203

  Fly  1384 AGSLDELKPK-PKVSQQQQQSQQQQQPTKRARN----RIDHWQLDSSWEFMAKQDTGSHAGGDYD 1443
            ...::|.:.: .:.:.::..||....|.:|.:.    .|..::.|..|.        .|
Mouse   204 QRKMEERRLRLQEAANRRFCSQVALTPEEREQRALYAAILEYEQDHDWP--------KH------ 254

  Fly  1444 TAAIDWQEKENSLGRDSRADGQGKKRTLTIHQIIANRLPDLNLPELVR----------------- 1491
                 |:.|.      .|:.|.....|..:..:::  |||..:.:|::
Mouse   255 -----WRAKL------KRSPGDLSLVTSLLSHLLS--LPDHPISQLLKKLQCAVYSALYPIVSRA 306

  Fly  1492 ----------CSTPPQTAALQPHVLGQDKAGVGCDGSQKSFQSQIGCRLSSYDNVFCQNSFGGID 1546
                      ||.||:.            .|:...||:         ||.|..:::|.
Mouse   307 ATSAAPAPGSCSLPPEA------------NGLLAPGSR---------RLRSSQSLYCM------- 343

  Fly  1547 SAQSDDGTIFSEPWDSSQWDTFLPHDDATINSDTIHLSKCRPALSEDDTIVEELQSTKDGSNGSC 1611
                                                ||...|:.:         ....||...:
Mouse   344 ------------------------------------LSPSEPSAA---------PRVLDGPPPT- 362

  Fly  1612 NQDTLKANRNGAGHHKLNNGNGNGKANNRPKVATILRNPSMRDREVLCHPRNKMSIQSSGPGDSL 1676
                                         |.|.|:...|  .|||....|        :||...|
Mouse   363 -----------------------------PSVPTLHSGP--LDREADGSP--------AGPSSPL 388

  Fly  1677 RAYTLQLAQDPSSTFARNIENFICCTKESREAAPQVVMRNMRQFMSGMKNYLVKHGEGKFHAELE 1741
             ...|....|..|:| .::|.|:..::      ||.........:..:|: .||        ::.
Mouse   389 -VDALSHLPDKDSSF-EDLEQFLAMSE------PQTPGAKREPLLECLKS-TVK--------DIH 436

  Fly  1742 TARARLKSDEFLNLDAMLETVMHQ-----LVVLPLREHLYGIFVDHYQRSEDIQLLAQNVRYACE 1801
            .|..||.|...|..:: |.|...:     .:..|....|:.:.:..|:.....:..|.:......
Mouse   437 NAIDRLLSLTLLAFES-LNTATSKDRCLACIEEPFFSPLWPLLLALYRSVHRTREAAVSRSMELY 500

  Fly  1802 REAADFGIRPTVTPPSQAALRLIANLLWRLQEAE--------------------LPLDKLELFLC 1846
            |.|          ||:  ||.:...||.|:.||:                    .|..|||   |
Mouse   501 RNA----------PPT--ALGIPTKLLPRVPEAQASTYPYCTAAQELGLLVLESCPQKKLE---C 550

  Fly  1847 VISTVFDATGC-----------PRGQQ-------LGADDFLPVLVYVVAKCGFVGAEIEAEFMWG 1893
            ::.|:.....|           |.|:.       .||||.||:|.:||.:.|......|...:..
Mouse   551 IVRTLRVICICAEDYCRAQEARPEGESQPPAAAISGADDLLPILSFVVLRSGLPQLVSECAALEE 615

  Fly  1894 LLQPTLLNGEPGYYLTALCSAVQVLKTFMASEG 1926
            ......|.||.||.||:|.||:..::  :.|.|
Mouse   616 FTHEGYLIGEEGYCLTSLQSALSYVE--LLSRG 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spri	NP_001259418.1	SH2	716..813	CDD:472789
		VPS9	1824..1922	CDD:460489	35/135 (26%)
		RA_Rin	1946..2030	CDD:340474
Vps9d1	NP_001297590.1	MIT	13..82	CDD:461228	10/68 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	348..393		14/94 (15%)
		VPS9	528..644	CDD:460489	30/120 (25%)