Protein Alignment spri and rin2b

DIOPT Version :10

• Sequence 1: NP_001259418.1
• Gene: spri / 31987
• FlyBaseID: FBgn0085443
• Length: 2043
• Species: Drosophila melanogaster
• Sequence 2: XP_017212050.1
• Gene: rin2b / 565615
• ZFINID: ZDB-GENE-030131-7043
• Length: 899
• Species: Danio rerio
• Alignment Length: 1442
• Identity: 264/1442 - (18%)
• Similarity: 412/1442 - (28%)
• Gaps: 627/1442 - (43%)

  Fly   618 SRRSSSVDPDADADDVVDAAHGGAFEDDM--QALLPKCSRRSRDELSQSRTSLVSSSEGGILAEG 680
            |.:.|.:|.......:|||.   |...|.  |.::.....:.||....|.||::...||..|...
Zfish     5 SAQPSRMDRSGSFLQLVDAF---ALSLDQLEQQIIHAVQEKDRDPDRDSDTSMLIQIEGECLQYP 66

  Fly   681 ETSSEDDEEEPVEAEDEGEESSRDSSDNSPPCDLGLMERLLVTHPMWFLPGIQRSGAVHLLQGKE 745
            |.              :|..:|...|         ::::|:.|||:|.|..|.:..|..:|..:.
Zfish    67 EV--------------DGACASSGVS---------VLDKLIHTHPIWLLLSIDQQEATGILLQQP 108

  Fly   746 EGTFIVRGSSQPNTMAVSVRLPQDTGPYIEHYLIQSHDNVLSLESSRFTFGSIPSLIAHYAQCCD 810
            .|.|:|..||......:|.::...:...:.|..::......|||.|..:|..:..|:|.|....|
Zfish   109 AGVFLVWKSSVLQKKMLSFQMRDASDACVLHVPVKESQYTFSLEGSNISFADLFRLVAFYCISRD 173

  Fly   811 ELPVQLMLPRVLREANNRKKLSSLALLGQEFWSYVSSPALLGPLTPSVAPSKDQQLLDAKSPLSL 875
            .||..|.||..:..|.....|..:|..|..||..                |.:||.....:|.||
Zfish   174 ILPSTLKLPEAIYSAETLSDLHEVAKQGAGFWEC----------------SLNQQHRTFSAPGSL 222

  Fly   876 -----TETSGLGTATFFSDTV----SKPPPTG--APPLPGGGLFSPTGSGQLLGFFSQAGTPSDT 929
                 |.....||.   ||.:    ....|||  .|||...   ||..|             ...
Zfish   223 LVQGRTSICIEGTC---SDVLPGEDQTCSPTGNLIPPLTDN---SPNAS-------------KGE 268

  Fly   930 TNSSLSSFTTSGGQHMQLLSPNSVDSVILTMSPVDNPGHYLPGSTGAPMAPLCPSVVDQQLSTFK 994
            ::|:||....:..:..|.||.|:...:...::..:...|..|
Zfish   269 SSSALSFINPTFLKTQQDLSQNAATVITDDLAAGNRKSHPAP----------------------- 310

  Fly   995 VAQTAPEVDQVRPQRPKPPNTLNLKPPAP------PLRWSKPHSPDQNGSANGNFTVTTTVTFSM 1053
                        |.||.||..|...|..|      |||
Zfish   311 ------------PPRPPPPRILICGPVVPQISRNMPLR--------------------------- 336

  Fly  1054 ENGGGGGSGPTVGNGNGKFVEVTTPAASNPFNALLNGQASTFQTFAKRLSPEGECKDTLSSQGSS 1118
                                                         |.|:|...  |....|.||.
Zfish   337 ---------------------------------------------ASRMSQRP--KSVTGSTGSK 354

  Fly  1119 SNDSRWPPPARKLLTSPMTPLTPSGGSSSSGGKSRKSRAGKESQHYKESDILESPPMQYCASALS 1183
            ...|:.|        :|..|..|                  :...|:            |..||.
Zfish   355 HPSSKKP--------APRPPEPP------------------DIDSYR------------CTIALD 381

  Fly  1184 DKISDYEDVWSHDPSDRASLLTSFRPALDTVGGVMNRRPDLLAETPSTPTPTQQSHLTPCEEETT 1248
            |                           ||:...:::              ..|||        |
Zfish   382 D---------------------------DTISRAISQ--------------ANQSH--------T 397

  Fly  1249 ATPNESSSQSLLQFSG-DVPARSRAGLLLPNLSGQVPPVAMTKSMTAAEDDGGDTTPTAEGQANG 1312
            ...|.|||..|.|::| :...||.:|                :|::.:..|..|:.|
Zfish   398 TLLNPSSSSILQQWTGQEEKGRSSSG----------------QSLSTSSSDSLDSPP-------- 438

  Fly  1313 ASRSKQGSPFYAEPADALRQAGLTSAATAILRRQHRSQMLHASQRHSEPLKAGFGGSGNGAMLQP 1377
                                              |...:.|.||
Zfish   439 ----------------------------------HPLPLGHVSQ--------------------- 448

  Fly  1378 SDLEKLAGSLDELKPKPKVSQQQQQSQQQQQPTKRARNRIDHWQLDSSWEFMAKQDTGSHAGGDY 1442
                                                                         |...
Zfish   449 -------------------------------------------------------------GLST 452

  Fly  1443 DTAAIDWQEKENSLG----RD----SRADGQGKKRTLTIHQIIANRLPDLNLPELVRCSTPPQTA 1499
            |.:..|:.|:|...|    ||    .||..:.||  |...:::..|...|.||..:|
Zfish   453 DDSTDDYDEEEEDYGVGLERDLQLRLRASRKSKK--LLAVELVGTRPRSLVLPRALR-------- 507

  Fly  1500 ALQPHVLGQDKAGVGCDGSQKSFQSQIGCRLSSYDNVFCQNSFGGIDSAQSDDGTIFSEPWDSSQ 1564
                                                                             
Zfish   508 ----------------------------------------------------------------- 507

  Fly  1565 WDTFLPHDDATINSDTIHLSKCRPALSEDDTIVEELQSTKDGSNGSCNQDTLKANRNGAGHHKLN 1629
                             |..|.|..|:
Zfish   508 -----------------HFRKVRGVLN-------------------------------------- 517

  Fly  1630 NGNGNGKANNRPKVATILRNPSMRDREVLCHPRNKMSIQSSGPGDSLRAYTLQLAQDPSSTFARN 1694
                                       ||..|..::.:|           .::|:||..|.|...
Zfish   518 ---------------------------VLATPEKRILLQ-----------IIELSQDKGSYFGCL 544

  Fly  1695 IENFICCTKESR--EAAPQVVMRNMRQFMSGMKNYLVKHGEGKFHAELETARARLKSDEFLNLDA 1757
            :::::...:|::  .::.|.:::.:||||:.||.||.:..|  .:..:|   :.:..|:   :|.
Zfish   545 VQDYVSFVQENKNCHSSSQDLLQTIRQFMTQMKAYLKQSSE--MNPPIE---SYMPEDQ---IDP 601

  Fly  1758 MLETVMHQLVVLPLREHLYGIF---VDHYQRSEDI-QLLAQNVRYACEREAADFGIRPTVTPPSQ 1818
            :||..||:.|:.|    |||..   :..:|.:..: |.|.:|:..|..:...:.|:.....|.:.
Zfish   602 VLEKAMHKCVLKP----LYGCLHSALHEFQAAAGVWQTLQENLAIAKTKRPNELGVNGAQAPDTH 662

  Fly  1819 AALRLIANLLWRLQEAELPLDKLELFLCVISTVFDATGCPRGQQLGADDFLPVLVYVVAKCGFVG 1883
            |..| |...|..:.....|..|:.:.|.|...::........:..|||||||:|.||:.:|....
Zfish   663 AIQR-IRRKLRAMCSMYSPERKIMVLLKVCKLIYSIMQEHEVRMFGADDFLPMLTYVLVQCDMPQ 726

  Fly  1884 AEIEAEFMWGLLQPTLLNGEPGYYLTALCSAVQVLKTFMASE-----GESGSGSL-DWR-----S 1937
            .:.|..:|..|:.|.||:||.|||||:...|:.::|.|...:     ..:.|.:| .|.     .
Zfish   727 LDTEILYMMELIDPPLLHGEGGYYLTSAYGAMSLIKNFQEEQAARILSSATSDTLHQWHQRRTLQ 791

  Fly  1938 SCLPAC---SSVLRVIIPDECNGSLQTRTLPVRPHTTTREVCRIIAHKARITNPQDYALFKLVDG 1999
            ..||:.   .:.:||.: .:.:.....:||.|||:.||.||||:.|.|.|:::|::|.||.|.|.
Zfish   792 RNLPSVDDFQNYMRVAL-QKADSGCTAKTLQVRPYATTEEVCRLCALKFRVSDPENYGLFLLTDE 855

  Fly  2000 EETLLTDAECPQ 2011
            ....|.....||
Zfish   856 SSQQLAADTHPQ 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spri	NP_001259418.1	SH2	716..813	CDD:472789	25/96 (26%)
		VPS9	1824..1922	CDD:460489	32/97 (33%)
		RA_Rin	1946..2030	CDD:340474	25/66 (38%)
rin2b	XP_017212050.1	SH2_RIN2	79..178	CDD:198257	27/98 (28%)
		VPS9	679..779	CDD:473191	31/99 (31%)
		Ubl1_cv_Nsp3_N-like	800..887	CDD:475130	25/69 (36%)