DRSC/TRiP Functional Genomics Resources

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Protein Alignment spri and RIN2

DIOPT Version :9

Sequence 1:NP_001259418.1 Gene:spri / 31987 FlyBaseID:FBgn0085443 Length:2043 Species:Drosophila melanogaster
Sequence 2:XP_011527557.2 Gene:RIN2 / 54453 HGNCID:18750 Length:962 Species:Homo sapiens


Alignment Length:1441 Identity:273/1441 - (18%)
Similarity:431/1441 - (29%) Gaps:617/1441 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly   651 PKCSRRSRDELS---------QSRTSLVS-----SSEGGILAEGETSSEDDEE---EPVEA---- 694
            |.||..|..|::         ..|.|...     :||.|.|.:....::.:.|   ||.|.    
Human    58 PACSGASLGEMTAWTMGARGLDKRGSFFKLIDTIASEIGELKQEMVRTDVNLENGLEPAETHSMV 122

  Fly   695 ---------EDEGEESSRDSSDNSPPCDLGLMERLLVTHPMWFLPGIQRSGAVHLLQGKEEGTFI 750
                     |::.:..:|||..:|....|.:::|||.|||:|....:....|..:||.:..|.|:
Human   123 RHKDGGYSEEEDVKTCARDSGYDSLSNRLSILDRLLHTHPIWLQLSLSEEEAAEVLQAQPPGIFL 187

  Fly   751 VRGSSQPNTMAVSVRLPQDTGPYIEHYLIQSHDNVLSLESSRFTFGSIPSLIAHYAQCCDELPVQ 815
            |..|::.....:|:|||.:.|..::.:.|:......|||.|..:|..:..|||.|....|.||..
Human   188 VHKSTKMQKKVLSLRLPCEFGAPLKEFAIKESTYTFSLEGSGISFADLFRLIAFYCISRDVLPFT 252

  Fly   816 LMLPRVLREANNRKKLSSLALLGQEFWSYVSSPALLGPLTPSVAPSKDQQLLDAKSPLSLTETSG 880
            |.||..:..|.:..:|..||.:|..||   ||||                  |:|.|        
Human   253 LKLPYAISTAKSEAQLEELAQMGLNFW---SSPA------------------DSKPP-------- 288

  Fly   881 LGTATFFSDTVSKPPPTGAPPLPGGGLFSPTGSGQLLGFFSQAGTPSDTTNSSLSSFTTSGGQHM 945
                       :.|||                                  :..|||.........
Human   289 -----------NLPPP----------------------------------HRPLSSDGVCPASLR 308

  Fly   946 QLLSPNSVDSVILTMSPVDNPGHYLPGSTGAPMAPLCPSVVDQQLSTFKVAQTAPEVDQVRPQRP 1010
            ||...|.|.| |.|.:|                            |..:.:||...:..:.|   
Human   309 QLCLINGVHS-IKTRTP----------------------------SELECSQTNGALCFINP--- 341

  Fly  1011 KPPNTLNLKPPAPPLRWSKPHSPDQNGSANGNFTVTTTVTFSMENGGGGGSGPTVGNGNGKFVEV 1075
                           .:.|.||.|.:|......|.|.                   |.||     
Human   342 ---------------LFLKVHSQDLSGGLKRPSTRTP-------------------NANG----- 367

  Fly  1076 TTPAASNPFNALLNGQASTFQTFAKRLSPEGECKDTLSSQGSSSNDSRWPPPA-RKLLTSPMTPL 1139
                                                  ::.:.|...|.|||| ..|.|||....
Human   368 --------------------------------------TERTRSPPPRPPPPAINSLHTSPRLAR 394

  Fly  1140 TPSGGSSSSGGKSRKSRAGKESQHYKESDILESPPMQYCASALSDKISDYEDVWSHDPSDRASLL 1204
            |                   |:|                        :...:..:|:.....:| 
Human   395 T-------------------ETQ------------------------TSMPETVNHNKHGNVAL- 415

  Fly  1205 TSFRPALDTVGGVMNRRPDLLAETPST-PTPTQQSHLTPCEEETTATPNESSSQSLLQFSGDVPA 1268
                                    |.| |||                                  
Human   416 ------------------------PGTKPTP---------------------------------- 422

  Fly  1269 RSRAGLLLPNLSGQVPPVAMTKSMTAAEDDGGDTTPTAEGQANGASRSKQGSPFYAEPADALRQA 1333
                          :||..:.|..:..|.:||  ..|..|...||                    
Human   423 --------------IPPPRLKKQASFLEAEGG--AKTLSGGRPGA-------------------- 451

  Fly  1334 GLTSAATAILRRQHRSQMLHASQRHSEPLKAGFGGSGNGAMLQPSDLEKLAGSLDELKPKPKVSQ 1398
                                     ...|:.|..||..||                   .|:.  
Human   452 -------------------------GPELELGTAGSPGGA-------------------PPEA-- 470

  Fly  1399 QQQQSQQQQQPTKRARNRIDHWQLDSSWEFMAKQDTGSHAGGDYDTAAIDWQEKENSLGRDSRAD 1463
                                                   |.||                      
Human   471 ---------------------------------------APGD---------------------- 474

  Fly  1464 GQGKKRTLTIHQIIANRLPDLNLPELVRCSTPPQTAALQPHVLGQDKAGVGCDGSQKSFQSQIGC 1528
                          ..|.|            ||.:.:..|           |.|.::        
Human   475 --------------CTRAP------------PPSSESRPP-----------CHGGRQ-------- 494

  Fly  1529 RLSSYDNVFCQNSFGGIDSAQSDDGTIFSEPWDSSQWDTFLPHDDATINSDTIHLSKCRPALS-E 1592
            |||                    |.:|                  :|.:||::...:..|... |
Human   495 RLS--------------------DMSI------------------STSSSDSLEFDRSMPLFGYE 521

  Fly  1593 DDTIVEELQSTKDGSNGSCNQDTLKANRNGAGHHKLNNGNGNGKANNRPKVATILRNPSMRDREV 1657
            .||     .|:.:...|..:|:|:                           |..:::...|....
Human   522 ADT-----NSSLEDYEGESDQETM---------------------------APPIKSKKKRSSSF 554

  Fly  1658 LCHPRNKMSIQS-SG-------PGDSLRAYTLQLAQDPSSTFARNIENFICCTKESRE--AAPQV 1712
            :.....|..:|. ||       |...:.....:|::|..:.|...:::::...:|::|  .:...
Human   555 VLPKLVKSQLQKVSGVFSSFMTPEKRMVRRIAELSRDKCTYFGCLVQDYVSFLQENKECHVSSTD 619

  Fly  1713 VMRNMRQFMSGMKNYLVKHGEGKFHAELETARARLKSDEFLNLDAMLETVMHQLVVLPLREHLYG 1777
            :::.:||||:.:||||.:      .:||:.....|..::  .:|.:||..||:.::.||:.|:..
Human   620 MLQTIRQFMTQVKNYLSQ------SSELDPPIESLIPED--QIDVVLEKAMHKCILKPLKGHVEA 676

  Fly  1778 IFVDHYQRSEDIQLLAQNVRYACEREAADFGI-RPTVTPPSQAALRLIANLLWRLQEAELPLDKL 1841
            :..|.:......:.|.:|::...:|...:.|: .||   |....:..|......:|:...|..|:
Human   677 MLKDFHMADGSWKQLKENLQLVRQRNPQELGVFAPT---PDFVDVEKIKVKFMTMQKMYSPEKKV 738

  Fly  1842 ELFLCVISTVFDATGCPRGQQLGADDFLPVLVYVVAKCGFVGAEIEAEFMWGLLQPTLLNGEPGY 1906
            .|.|.|...::.......|:..|||||||||.||:|:|..:..:.|.|:|..||.|:||:||.||
Human   739 MLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGY 803

  Fly  1907 YLTALCSAVQVLKTFMASE------GESGSGSLDWR-----SSCLPAC---SSVLRVIIPDECNG 1957
            |||:...|:.::|.|...:      .|:......|.     :..:|:.   .:.|||.. .|.|.
Human   804 YLTSAYGALSLIKNFQEEQAARLLSSETRDTLRQWHKRRTTNRTIPSVDDFQNYLRVAF-QEVNS 867

  Fly  1958 SLQTRTLPVRPHTTTREVCRIIAHKARITNPQDYALFKLVDGEETLLTDAECPQDARLAAKGK-- 2020
            ....:||.|||:.||.:||:|.|.|.::.:|::|:||..||.....|.:...||..:.....:  
Human   868 GCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQ 932

  Fly  2021 -HCM-LAYKRI 2029
             |.. ..||||
Human   933 PHIFHFVYKRI 943

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
spriNP_001259418.1 SH2 716..813 CDD:301589 30/96 (31%)
VPS9 1821..1922 CDD:280383 38/100 (38%)
UBQ 1946..2026 CDD:294102 27/83 (33%)
RIN2XP_011527557.2 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165149889
Domainoid 1 1.000 76 1.000 Domainoid score I8962
eggNOG 1 0.900 - - E1_KOG2320
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 238 1.000 Inparanoid score I3373
Isobase 1 0.950 - 1 Normalized mean entropy S6079
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001291
OrthoInspector 1 1.000 - - otm41965
orthoMCL 1 0.900 - - OOG6_107356
Panther 1 1.100 - - O PTHR23101
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3144
SonicParanoid 1 1.000 - - X2330
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1312.770

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