DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment spri and rin-1

DIOPT Version :9

Sequence 1:NP_001259418.1 Gene:spri / 31987 FlyBaseID:FBgn0085443 Length:2043 Species:Drosophila melanogaster
Sequence 2:NP_001122880.1 Gene:rin-1 / 3565509 WormBaseID:WBGene00008183 Length:1890 Species:Caenorhabditis elegans


Alignment Length:2013 Identity:463/2013 - (23%)
Similarity:728/2013 - (36%) Gaps:622/2013 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   418 PSPVPRCHSS--------SSTSSVSE-STSCSSSADYSLREQLKNFANRNSEGGGTIDSTARLIK 473
            ||....|:|:        |...:|.| .|||||::|   ....:..|...|.|||...|:    .
 Worm   109 PSGSSSCNSNYLEPIIDISLYDNVEEIGTSCSSASD---SMSARAIAAARSRGGGAAPSS----N 166

  Fly   474 GMSLPV-----GDQSVQ---------SVAPAL----CDSLL--SPQEVPLGRRYAEVAQFKGHPK 518
            |...|:     .|::|:         :|.|.:    .|.::  |.:...:.||.::     |:|.
 Worm   167 GNERPLSAYEESDEAVRQRKNRRASVAVMPMMELEYRDQVVAGSIKSATMNRRKSD-----GNPA 226

  Fly   519 ARTSEPIPSGVATPSSLDSASVDGGKSHTGNNNNINNNHNGQQSQKSQQQAGLAAKLNVLAQSNL 583
            .|...|                |.|                            |.::.|      
 Worm   227 GRAFSP----------------DFG----------------------------AIRVQV------ 241

  Fly   584 NNNNTTNQPGSMTPASNRTGLDSNQNQKQNLNADSRRSSSVDPDADADDVVDAAHGGAFEDDMQA 648
              .:.|:.||||....:    |...::|..||..  ||.....:...:.:.|.|..|       :
 Worm   242 --EDITSVPGSMMTEDD----DDVDDEKHGLNGG--RSFDNGGETSTETITDVALNG-------S 291

  Fly   649 LLPKCSRRSR-------------DELSQSRTSLVSSSEGGILAEGETSSEDDEEEPVEA------ 694
            ||....|.|.             .|||||..                  |:....|:.|      
 Worm   292 LLMASGRVSEWAVPIEYASSPIAQELSQSEV------------------EERPRPPIPAMYINTS 338

  Fly   695 --------EDEGEES-------SRDSSDNS-PPCDLGLMERLLVTHPMWFLPGIQRSGAVHLLQG 743
                    .|.||||       .|:||.:| ....:.|:|:::.||.:|:||.:.|...:|||:.
 Worm   339 SSTTTAPTADRGEESVYSDFVLKRNSSTSSMSGKSVTLLEQIIRTHAVWYLPHMGRPEVLHLLRR 403

  Fly   744 KEEGTFIVRGSSQPNTMAVSVRLPQDTGPYIEHYLIQ-----------------SHDNVLSLESS 791
            .|.|.||||.|::.|.||:||||.......|:||:|:                 :....:.||.|
 Worm   404 MEPGNFIVRASTRENCMALSVRLAPGAHVEIDHYIIEKLVVPLKPTTSKEPAAPTTAKAVRLEGS 468

  Fly   792 RFTFGSIPSLIAHYAQCCDELPVQLMLPRVLREANNRKKLSSLALLGQEFWSYVSSPALLGPLTP 856
            ..||.|:|.||.||....|||..:|.||..:|.....|:|.|:|::.|||||...|  |.....|
 Worm   469 PLTFRSLPLLIEHYCVNEDELEHRLQLPSAIRACTTTKQLLSIAMMEQEFWSCEMS--LSRKAAP 531

  Fly   857 SVAPSK---------------------------------------------DQQLLDAKSPLSLT 876
            |.:.|:                                             |:.:.|...|..:.
 Worm   532 STSSSRNSISSSLRSSSNNNNNSSNTMPRCHGTAESDASTWFMDRPKVVVDDESIYDEVEPRMMG 596

  Fly   877 ETSGLGTATFFS--DTVSKPPP--TGAPPLPGGGLFSPTGSGQLLGFFSQAGTP---SDTTNSSL 934
            ..:|:|...:::  ||.|....  ...|......|.||.   ..:....|..:.   |.:.:||.
 Worm   597 SKTGVGGGGYYAVHDTKSSSNTLNNNIPRRSSAMLLSPE---MAMNSEQQKNSKKRRSSSRSSSN 658

  Fly   935 SSFTT----------SGGQHMQLLSPNSVDSVILTMSPVDNPGHYLPGSTGAPMAPLCPSVVD-- 987
            |.|.|          .|....:.:..:..||.:.|.||                    ||..|  
 Worm   659 SRFATVCVGGFDGWNGGTSSSKQVDTDETDSGLSTHSP--------------------PSKHDRL 703

  Fly   988 ------------QQLSTFKVAQTAPEVDQ------VRP--------------QRPKPPNTLNLKP 1020
                        |.:.:.|....:|::..      .||              :..|...:|:: .
 Worm   704 DDVHISRSDRRSQSVRSHKSVTASPKLGHSTSSTLSRPRSFLRSLLSFGSSNKEHKRKESLDI-D 767

  Fly  1021 PAPPLRWSKPHSP-DQNGSANGNFTVTTT-----VTFSMENGGGGGSGPTVGNG-----NGKFVE 1074
            ..|.|...:..:| |.||:   |..|.|:     :|.....|..|...|...||     :..:.:
 Worm   768 STPRLASCEYFTPWDTNGT---NMQVRTSRSAFDITNPPARGFFGSGSPKKRNGIMPSTSSVYQK 829

  Fly  1075 VTTPAASNPF------------------------NALLNGQASTFQTFAKRLSPEGECKDTLSSQ 1115
            ..:.::||.|                        |.|.:....||:      .|..:  |...|.
 Worm   830 NASSSSSNMFDDDNYTRGWKEAAYAETSPHHNNNNHLTDAAMRTFK------PPNYD--DVAGSS 886

  Fly  1116 GSSSNDSRWPPPARKLLTSPMTPLTPSGGSSSSGGKSRKSRAGKESQHYKES----DILESPPMQ 1176
            .:||..||..|.|.:...|.:      |..|:......||.|.:.:.|.:.|    ..:...||.
 Worm   887 ATSSPSSRSRPLAMRRERSDI------GVISNGMNLGVKSNAQRLAYHNESSPGPAHAIGRVPMT 945

  Fly  1177 YCASALSDKISDYEDVWSHDPSDRASLLTSF-RPALDTVGGVMNRRPDLLAETPSTPTP---TQQ 1237
            ..|:|             .||..:.:.:... |..|.:...:::.:     |.||:..|   ...
 Worm   946 PPANA-------------GDPQVQQNCVEELRRKRLQSTNEMLSPK-----ELPSSKHPHGEVHS 992

  Fly  1238 SHLTP--CEEETTATPNESSSQSLLQFSGDVPA--RSRAG---LLLPNLSGQVPPV---AMTKSM 1292
            :|.:|  ........|:.|:|.:....:....|  |:|..   |.:|||.....|:   ::.:|.
 Worm   993 AHASPQIAMRRRNGFPSPSASHNGFNRNNAFAAIDRNRGSDHRLSVPNLIAATDPLVPGSVGQSA 1057

  Fly  1293 TAAEDD-GGDTTP-----TAEGQANGASRSKQGSPFYAEPADALRQAGLTSAAT-------AILR 1344
            .|..:. ||.||.     ..||......|.|..:     ||....:...|:|.:       .:.|
 Worm  1058 KALRERLGGRTTDGDLMVINEGLVTPVVRRKTFA-----PATTTTKTTATAATSMDELGGEVMRR 1117

  Fly  1345 RQHRSQMLHASQRH-SEPLKAGFGGSGNGAMLQPSDLEKLAGSLDELKPKPKVSQQQQQ--SQQQ 1406
            |:.....::..:|| |:.|.:|           .||...|.      :.|...|.|..|  :.:.
 Worm  1118 REALEAAMNEKRRHPSDSLSSG-----------SSDHSSLG------RRKTSTSSQAHQLGTTES 1165

  Fly  1407 QQPTKRARNRIDHWQLDSSWEFMAKQDTGSHAGGDYDTAAIDW-----QEKENSLGRDSRADGQG 1466
            :...:||:|.      :.....:|...:....||....:||:.     |:|...:....:..|..
 Worm  1166 ELVWRRAKNN------NPPSSTVAPSTSSKSGGGTSHWSAINHEIKNRQQKIAKVLPTPQPRGHH 1224

  Fly  1467 KKRTLTIHQIIANRLPDLNLPELVRCSTPPQTAALQPHVLGQDKAGVGCDGSQKSFQSQIGCRLS 1531
            ..||::    |....|.:    :..|......|.|.......||.|:..|     ..|:|.    
 Worm  1225 HNRTMS----IVGGPPSV----ISECRRSSDYAQLCDFASSTDKNGIHLD-----VHSKIE---- 1272

  Fly  1532 SYDNVFCQNSFGGIDSAQSDDGTIFSEPWDSSQWDTFLP---HDDATINSDTIHLSKCRPALSED 1593
                          |.|.|..||:|:|||||:.|:..|.   |.|    ..|:.|....|...||
 Worm  1273 --------------DDAVSVAGTVFNEPWDSNVWENLLDLAHHGD----ESTMGLKVSEPIQEED 1319

  Fly  1594 DTIVEELQSTKD---GSNGSCNQD-------------------------------TLKA--NRNG 1622
                    |..|   |.:.:|..|                               |:||  ..:.
 Worm  1320 --------SDSDRTAGGDSTCQMDSDEDDDDDDEDEMIRWQTEKMMRRPLPSDRVTVKAWEQDSD 1376

  Fly  1623 AGHHKLNNGNGNGKANNRPKVATILRNP--SMRDREVLCHPR-----------NKMS-------- 1666
            ||..|.|......| |.....:|:.|.|  |...|.:   ||           |.||        
 Worm  1377 AGSSKFNTLESRSK-NGSIAGSTLRRQPEGSFSIRSL---PRALSRFSHTLGMNGMSAAASFGSI 1437

  Fly  1667 ------IQSSGP---------------------GDSLRAYTLQLAQ---DPSSTFARNIENFICC 1701
                  :.|..|                     |.:::.|..:|||   ..::.|...:..|:.|
 Worm  1438 DDLPTTLPSMSPLLSGRVSRAQLPRSSSTDEKIGRAVQNYVEELAQVKEGDNACFGLTLRQFVAC 1502

  Fly  1702 TKESREAAPQVVMRNMRQFMSGMKNYLVKHGEGKFHAELETARARLKSDEFLNLDAMLETVMHQL 1766
            ||:::|..|.||:||:|||::||||||||||||..|..::...:||.|::.||:||:||.|:|:|
 Worm  1503 TKDTKETDPAVVIRNVRQFINGMKNYLVKHGEGDLHHIIDEESSRLNSNQILNIDAVLEAVLHKL 1567

  Fly  1767 VVLPLREHLYGIFVDHYQRSEDIQLLAQNVRYACEREAADFGIR--PTVTPPSQAALRLIANLLW 1829
            ::..::..||.:.:..:.::..:||::||.....:....:.|..  .::..||.:.:..:..|:.
 Worm  1568 LLREVKPLLYHVMIKEHSKAGALQLISQNQGVVRKMNLTELGFSNPESLVTPSSSIMEQVKLLMR 1632

  Fly  1830 RLQEAELPLDKLELFLCVISTVF--------------DATGCP-RGQQLGADDFLPVLVYVVAKC 1879
            ::|....|:.|||..:..:..|.              |...|. ||...| ||.:...||::::.
 Worm  1633 KMQNHYSPMKKLENLMKAVGLVLGCQVNNGNENENPTDPMSCGYRGLPPG-DDLVRWFVYILSRT 1696

  Fly  1880 GFVGAEIEAEFMWGLL-QPTLLNGEPGYYLTALCSAVQVLKT----------------------F 1921
            ..||.|:||.:||.|| ||.:...:..||||:|.|||.|||:                      .
 Worm  1697 STVGCEVEAWYMWELLPQPIVTQSDASYYLTSLWSAVHVLKSTESIRRLCENDQRVIVSHDSSRH 1761

  Fly  1922 MASEGESGSGSLDWRSSC-LP------ACSSVLRVIIPDECNGSLQTRTLPVRPHTTTREVCRII 1979
            :.|.....:.:|...:|. :|      .|.:.:::.:|||..|.::..|.|..|..||.::.|::
 Worm  1762 LCSSPLLSTATLTRGTSAGIPQVISAATCDAFVKIAVPDEAVGCVRYATFPGVPMLTTSKLSRLV 1826

  Fly  1980 AHKARITNPQDYALFKLVDGEETLLTDAECP--QDARLAAKGKHCMLAYKRIDAKIAWPTAQL 2040
            ||:..||||:::.|:.:.:|.|:.|:.:|||  ...:|....|..|.||||.:||||||.|.:
 Worm  1827 AHQQGITNPEEHGLYLIAEGFESCLSPSECPVLVHEQLKKDKKPHMFAYKRHEAKIAWPRAAI 1889

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
spriNP_001259418.1 SH2 716..813 CDD:301589 42/113 (37%)
VPS9 1821..1922 CDD:280383 38/138 (28%)
UBQ 1946..2026 CDD:294102 26/81 (32%)
rin-1NP_001122880.1 SH2 376..489 CDD:387587 41/112 (37%)
VPS9 1624..1738 CDD:388595 37/114 (32%)
RA_Rin 1791..1879 CDD:340474 30/87 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160166774
Domainoid 1 1.000 61 1.000 Domainoid score I6978
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 317 1.000 Inparanoid score I1521
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG28928
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001291
OrthoInspector 1 1.000 - - oto18878
orthoMCL 1 0.900 - - OOG6_107356
Panther 1 1.100 - - LDO PTHR23101
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3144
SonicParanoid 1 1.000 - - X2330
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1111.020

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