Protein Alignment spri and Gapvd1

DIOPT Version :10

• Sequence 1: NP_001259418.1
• Gene: spri / 31987
• FlyBaseID: FBgn0085443
• Length: 2043
• Species: Drosophila melanogaster
• Sequence 2: NP_572704.1
• Gene: Gapvd1 / 32070
• FlyBaseID: FBgn0030286
• Length: 1712
• Species: Drosophila melanogaster
• Alignment Length: 1687
• Identity: 328/1687 - (19%)
• Similarity: 519/1687 - (30%)
• Gaps: 593/1687 - (35%)

  Fly   655 RRSRDELSQSRTSLVSSSEG---GILAEGETSSEDDEEE------PVEAED----EGEESSRDSS 706
            :|..:.|..:|..|.::...   |:|:|.|...:.|..:      |.|.|.    ||:|..:.:.
  Fly   193 QRLVESLFSARIFLTAALHAPLMGVLSEHEIWLDLDPHKLMQTFTPKEREKRFGREGDEEYQRNV 257

  Fly   707 DNSPPCDLGLMERLLVTHPMWFLPGIQRSGAVH------LLQGKEEGTFIVRGSSQPNTMAVSVR 765
            .......||.:.    :|...|:..:|:|.|:.      |||...:.   :|.|.:.....:...
  Fly   258 ARFHAETLGKLH----SHVQEFVKSLQQSWALFPSSLRWLLQTLSQQ---LRQSLRHEEQEIRQL 315

  Fly   766 LPQDTGPYIEHYL---IQSHD-----NVLSLESSRFTFGSIPSLIAHYA-QCCDELPVQLMLPRV 821
            |   |.....|::   |.|.|     :|...|..|.....|..|:...| ...|...||||...:
  Fly   316 L---TDLVFTHFISPAIASADLLGIIDVNVSERMRHNLNQIVKLLQRLALNDEDSELVQLMELLM 377

  Fly   822 LRE--------------------ANNRKKLSSLALLGQEFWSYVSS--------------PALLG 852
            |.:                    |.|:::|:.|.    ||:..:::              ..:||
  Fly   378 LGQTGEDVVAILPQQSDFERSQLAINQRELAQLV----EFFRLLTARDEYDISVEERQRLQRILG 438

  Fly   853 PL----------TPSVAPSKDQQLLDAKSPLSLTETSGLGTA--------TFFSDTVSKPPPTGA 899
            .:          ||..||  |.:....||..|......||.|        :|.|.:.:..|...:
  Fly   439 RIPKQQVQQQQQTPKDAP--DSRESPEKSKKSNKSLMSLGKAKKKLAKGMSFSSGSSNHNPVPVS 501

  Fly   900 PPLPGGGLFSPTGSGQLLG-------------FFSQAGTPSDTTNSSLSSFTTS----------- 940
            .||..|...:..|||.|..             ..|..|....|||..|...|:|
  Fly   502 EPLTNGQANTSNGSGGLGADLEHCSSHSGSNTSLSSCGANMPTTNDPLDMSTSSDPVLVFSLYNA 566

  Fly   941 GGQHMQLLSPNSVDSVILTMSPVDNPG-HYLPGSTGAPMAPLCPSVVDQQLSTFKVAQTAPEVDQ 1004
            |.:  ..|.|.:.:.| |.|:.:...| :.||..  ...|||.||..:..:|:.:..:
  Fly   567 GAK--SKLKPLTEEEV-LKMNSIGQDGSNLLPAV--VTTAPLAPSSNNDDVSSLEAMR------- 619

  Fly  1005 VRPQRPKPPNTLNLKPPAPPLRWSKPHSPDQNGSANGNFTVTTTVTFSMENGGGGGSGPTVGNGN 1069
             |||                                                    ...::||.:
  Fly   620 -RPQ----------------------------------------------------DDASIGNSD 631

  Fly  1070 GKFVEVTTPAASNPFNALLNGQASTFQTFAKRLSPEGECKDTLSSQGSSSNDSRWPPPARKLLTS 1134
            .  :|..:.||        :..||:.....::.....|.:|.||...|::...|..|......|
  Fly   632 N--LEAISEAA--------HSVASSLDLEEQQERDVHENEDNLSDMVSANVSGRGTPNISGRDT- 685

  Fly  1135 PMTPLTPSGGSSSSGGKSR--KSRAGKESQHYK------ESDILESPPMQYCASAL-----SDKI 1186
            |.:.:|...|:....|...  .:||....|..|      .|||.:    ::|...|     .:.:
  Fly   686 PSSQVTDGDGAGGDLGHHHGVHARAAANPQMQKMLLSKARSDIED----KFCKFELKKFEGDENV 746

  Fly  1187 SDYEDVWSHD--PSDRASLL---------------TSFRPALDTVGGVMNRRPDLLAET------ 1228
            |...|.||.|  .||..:.|               |...|:...:.|..|...:.||..
  Fly   747 SIISDTWSTDVLASDSENTLDATVSERGDRDRNFSTPLIPSAVVLPGDNNFVVEALARAGRVSGV 811

  Fly  1229 --PSTPTPTQQSHLTPCEEETTATPNESSSQSLLQFSGDVPARSRAGLLLPNLSGQVPPVAMTKS 1291
              |......|:|     |...:.....|.|:.|.:...|           .|:|      ..|||
  Fly   812 HGPQLDASDQRS-----ESNWSTDVLASDSEKLAEIDTD-----------DNVS------ITTKS 854

  Fly  1292 MTAA-------EDDGGDTTPTAEG-------QANGASRSKQGSPFYAEPADALRQAGLTSAATAI 1342
            .|.|       :||..:.||.:.|       :.||:.||::.|.|: :..::...|.|...|:::
  Fly   855 DTTAPQAAVLDDDDEDEQTPGSSGDGEPDPDRGNGSERSQEDSAFF-DAVNSYEDANLYHGASSL 918

  Fly  1343 LR-----------------RQHRSQMLHASQRHSEPLKAGFGGSGNGAMLQPSDLEKLAG--SLD 1388
            .|                 :|::.....:|.|.:.||      .|...|.:.:..|....  ||:
  Fly   919 ARSSVRTSYHVLGGESSFQQQYKCSGADSSGRKTTPL------MGTSCMRRQTSAESSISNQSLN 977

  Fly  1389 ELKPKPKVSQQQQ----------------------------QSQQQQQPTKRARNRIDHWQLDSS 1425
            ..:|.|.:.:...                            :.::.||..|..|:.||.......
  Fly   978 LEEPPPPMGKHHHHHREHHHRDYHHHHRERERERERERSALKKKKHQQQEKEHRDLIDFSDCSED 1042

  Fly  1426 WEFMAKQDTGSHAGG-----------DYDTAAIDWQE----------KENSLGRDSRADG--QGK 1467
            .|.:|:........|           |..|.|:....          ::.|...|.|.:|  .|.
  Fly  1043 KEELARNRDEEQPPGLVQQLLDMINQDEQTGAVSSSSPNVEHRRISIEQRSAIIDGRRNGILAGS 1107

  Fly  1468 KR-----TLTIHQIIAN-RLP--DLNLPELVRCSTPPQ--------TAALQPHVLG--------- 1507
            .|     ....|:|:.| .||  |.:..|::.|....|        :|.|:|.|.|
  Fly  1108 MRRHQSLNYENHEIMLNSMLPKTDDDKQEMLLCVQTQQLQLEERRGSAGLRPEVDGASGIAAAGG 1172

  Fly  1508 ------------------------QDKAGVGCDGS------------------------------ 1518
                                    :||.....||.
  Fly  1173 SGLKPPTKATGAIPKSISFDASADKDKQTYHRDGERDRERDRERERDRERDRERDRERDRERDHH 1237

  Fly  1519 ---------QKSFQSQIGCRLSSYDNVFCQ-NSFGGIDSAQSDDGTIFSEPWDSSQWDTFLPHDD 1573
                     |..|:::.|....:..|...| |......|.|:|..::..:|  |:..|.|..|
  Fly  1238 GAGIFNKLRQGIFKNRRGASAKNASNSSNQSNPAASTSSVQADIRSVSFDP--SAGCDNFGTH-- 1298

  Fly  1574 ATINSDTIHLSKCRPALSEDDTIVEELQSTKDGSNGSCNQDTLKANRNGAG-----------HHK 1627
               ..||          |||  |:.:.:.....|:.:.|.|: ..|.:|.|           |..
  Fly  1299 ---YCDT----------SED--ILAKYRRKVSSSSEATNSDS-TGNGHGVGSTGSVGAAAHLHKH 1347

  Fly  1628 LNNGNGNGKANN--RPKVATILRNPSMRDREVLCHPRNKMSIQSSGPGDSLRAY-TLQLAQDPS- 1688
            :|.|:..|....  :.|:.|:|....:...:.     .:.|..|:.....|:.| .:||||..|
  Fly  1348 MNGGHIPGVVFGCVKQKLRTVLSRTDLHSGDF-----RQTSTTSTTMATPLQIYLQIQLAQCISL 1407

  Fly  1689 ---STFARNIENFICCTKESREAAPQV---VMRNMRQFMSGMKNYLVKHGEGKF--HAELETARA 1745
               ...:...|...|..:..|....|:   :.|::.:..|.:: ||::|.:...  ..:||...|
  Fly  1408 QRLPQISHVAEALRCLAQLERPQHGQLLAELQRDLERRQSYLQ-YLMRHRQQLLLRSEQLEQLEA 1471

  Fly  1746 RLKSD-------------------------------EFLNLDAMLETVMHQLVVLPLREHLYGIF 1779
            ||:.:                               ||..|.|..|.|       .|.|......
  Fly  1472 RLRGEARSSQRCLLQALVRMYLAWSRQQEKLEQFQAEFAQLRASDERV-------ELTEEFVESL 1529

  Fly  1780 VDHYQRSEDIQ--LLAQNVRYACER--------------EAAD----------FGIRPTVTPPSQ 1818
            :...:.|.|:|  ......|.|.||              |.||          .|.......|:.
  Fly  1530 LQELRSSADLQDEWQVDAARVAIERMLLEQMYEQVMFPNEDADVSRDEVLSAHIGKLQRFVHPAH 1594

  Fly  1819 AALRLIANLL----WRLQEAEL--------PLDKLELFLCVISTVFDATGCPRGQQLGADDFLPV 1871
            .||.:....|    |...:.:|        |.:||:..:..||::........|:...|||.|||
  Fly  1595 PALCIAQEYLGEAPWTFAQQQLCHMAAYKTPREKLQCIINCISSIMSLLRMSSGRVPAADDLLPV 1659

  Fly  1872 LVYVVAKCG-------------FVGAEIEAEFMWGLLQPTLLNGEPGYYLTALCSAVQVLKT 1920
            |:|||....             |:|.::|              ||..:|.|...|.|:.:||
  Fly  1660 LIYVVIMANPPYLLSTVEYISCFLGKKLE--------------GEDEFYWTLFGSVVKFIKT 1707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spri	NP_001259418.1	SH2	716..813	CDD:472789	23/111 (21%)
		VPS9	1824..1922	CDD:460489	30/122 (25%)
		RA_Rin	1946..2030	CDD:340474
Gapvd1	NP_572704.1	RasGAP_RAP6	90..460	CDD:213331	58/282 (21%)
		MSCRAMM_ClfA	<546..910	CDD:468110	90/466 (19%)
		YhaN	1412..>1540	CDD:443752	24/135 (18%)
		VPS9	1609..1709	CDD:460489	29/113 (26%)