Protein Alignment spri and Rin3

DIOPT Version :10

• Sequence 1: NP_001259418.1
• Gene: spri / 31987
• FlyBaseID: FBgn0085443
• Length: 2043
• Species: Drosophila melanogaster
• Sequence 2: NP_001401858.1
• Gene: Rin3 / 314397
• RGDID: 1305849
• Length: 980
• Species: Rattus norvegicus
• Alignment Length: 1393
• Identity: 276/1393 - (19%)
• Similarity: 433/1393 - (31%)
• Gaps: 519/1393 - (37%)

  Fly   678 AEGETSSEDDEEEPVEAEDEGEESSRDSSDNSPP--------C----DLGLMERLLVTHPMWFLP 730
            ||...|:......|...:.||||.  :..|...|        |    .:.::|:|:.|.|:|...
  Rat     4 AEAPASAHPAGPIPDAGKGEGEED--EEKDGMRPRLPTTPRNCIPHRGISVLEKLVKTCPVWLQL 66

  Fly   731 GIQRSGAVHLLQGKEEGTFIVRGSSQPNTMAVSVRLP--QDTGPYIEHYLIQSHDNVLSLESSRF 793
            ||.::.|..:||.:..|.|:|...|....:.:.|..|  ::|...:..|.|:...::|.||.|..
  Rat    67 GIGQAEAAKILQQEMAGMFLVCRDSSLKRLVLCVHFPSLKNTSTEVLEYPIKEEKSILYLEGSVL 131

  Fly   794 TFGSIPSLIAHYAQCCDELPVQLMLPRVLREANNRKKLSSLALLGQEFWSYVSSPALLGPLTPSV 858
            .|..|..|||.|....|.||..|.||:.:.||::..:|.:::.||..||
  Rat   132 VFEDIFRLIAFYCVSRDLLPFTLRLPQAILEASSFLELETISNLGLGFW---------------- 180

  Fly   859 APSKDQQLLDAKSPLSLTETSGLGTATFFSDTVSKPPPTGAPPLPGGGLFSPTGSGQLLGFFSQA 923
                |..|..::.|.....:|..||          |..:|.|
  Rat   181 ----DSSLNSSRGPAEPLRSSAPGT----------PASSGRP----------------------- 208

  Fly   924 GTPSDTTNSSLSSFTTSGGQHMQLLSPNSVDSVILTMSPVDNP-GHYLPGSTGAPMAPLCPSVVD 987
              .:...|.|.....:.|...:..::|..::...|...|...| |.|  .:..||.||...|:..
  Rat   209 --ATHLANCSCEIELSVGNDRLWFVNPIFIEDCTLPADPPPLPIGSY--PTRPAPAAPDATSLTS 269

  Fly   988 QQLSTFKVAQTAPEVDQVRPQRPKPPNTLNLKPPAPPLRWSKPHSPDQNGSANGNFTVTTTVTFS 1052
            :.                .|:||.||      ||.|                    ||..|
  Rat   270 KG----------------SPRRPPPP------PPVP--------------------TVPPT---- 288

  Fly  1053 MENGGGGGSGPTVGNGNGKFVEVTTPAASNPFNALLNGQASTFQTFAKRLSPEGECKDTLSSQGS 1117
                     ||.
  Rat   289 ---------GPA----------------------------------------------------- 291

  Fly  1118 SSNDSRWPPPARKLLTSPMTPLTPSGGSSSSGGKSRKSRAGKESQHYKESDILESPPMQYCASAL 1182
                  |||                                             :||:|
  Rat   292 ------WPP---------------------------------------------APPVQ------ 299

  Fly  1183 SDKISDYEDVWSHDPSDRASLLTSFRPALDTVGGVMNRRPDLLAETPSTPTPTQQSHLTPCEEET 1247
                          |:|                           ..|::|||  .|||.|   ..
  Rat   300 --------------PAD---------------------------PLPNSPTP--NSHLAP---HA 318

  Fly  1248 TATPNESSSQSLLQFSGDVPARSRAGLLLPNLSGQVPPVAMTKSMT---------AAEDDGGDTT 1303
            ...|..|:.                           ||:...:|:.         ..|:....||
  Rat   319 PGPPGHSNQ---------------------------PPMTACESLPRPSVGLGPFGEEEMKPGTT 356

  Fly  1304 PTAEGQANGASRSKQGSPFYAEPADALRQAGLTSAATAILRRQHRSQMLHASQRHSEPLKAGFGG 1368
            |               ||.:..|...|                              |||.
  Rat   357 P---------------SPLHQAPPPPL------------------------------PLKK---- 372

  Fly  1369 SGNGAMLQPSDLEKLAGSLDELKPKPKVSQQ-QQQSQQQQQPTKRARNRIDHWQLDSSWEFMAKQ 1432
                             :|....|:.::|:: ..:||.....|.|.|:.|..
  Rat   373 -----------------TLPAAPPRRRISERVSLESQNVGTSTDRDRSGISR------------- 407

  Fly  1433 DTGSHAGGDYDTAAIDW--QEKENSLG-RDSRADGQGKKRTLTIHQIIANRLPDLNLPELVRCST 1494
                       ||:::.  |...:||| |..|...||:               |.........||
  Rat   408 -----------TASLNLPPQSTVSSLGDRSPRTTEQGQ---------------DTEAKASHADST 446

  Fly  1495 P-PQTAALQPHVLGQDKAGVGCDGSQKSFQSQIGCRLSSYDNVFCQNSFGGIDSAQSDDGTIFSE 1558
            | |...|.||.|....|..|     .:...|.....|:|           .|.....:.......
  Rat   447 PVPPGKAKQPPVPPPRKKRV-----SRQLASTFPSPLTS-----------PIPEVSPEKPAAPGA 495

  Fly  1559 PWDSSQWDTFLPHDDATINSDTIHLSKCRPALSEDDTIVEELQSTKDGSNGSCNQDTLKANRNGA 1623
            ||:.     ..|...|.:....:..|.|..:..|....:..|..:......:.:||:...:   :
  Rat   496 PWEG-----LSPAGQAGMQHLQVQTSACPQSSPEFKGSLASLSDSLGVPASAADQDSYSTS---S 552

  Fly  1624 GHHKLNNGNGNGKANNRPKVATILRNPSMRDREVLCHPRNKMSIQS--------SGPGDSLRAYT 1680
            ...:|...:.|.|           :.|||    :|...|:::|..|        ......|....
  Rat   553 AEEELEFSSPNVK-----------KKPSM----ILDKARHRLSFASFTSVFHAFLSSDRKLYKKV 602

  Fly  1681 LQLAQDPSSTFARNIENFICCTKE--SREAAPQVVMRNMRQFMSGMKNYLVKHGEGKFHAELETA 1743
            ::||||..|.|...::::...:.|  :|:.:...:::.:|..|:.:|:||::..|.|...|
  Rat   603 VELAQDKGSYFGSLVQDYKVYSLEMMTRQTSSTEMLQEIRTMMTQLKSYLLQSTELKALVE---- 663

  Fly  1744 RARLKSDEFLNLDAMLETVMHQLVVLPLREHLYGIFVDHYQRSEDIQLLAQNVRYACEREAADFG 1808
             ..|.|:|  .|:|::|:.:::.|:.||:|.:....::.:.|...:|.|.:|..........|.|
  Rat   664 -PTLHSEE--ELEAIVESALYKCVLKPLKEAINSSLLEIHSRDGSLQQLKENQLVILATTTTDLG 725

  Fly  1809 IRPTVTPPSQAALRLIANLLWRLQEAELPLDKLELFLCVISTVFD--ATGCPRGQQLGADDFLPV 1871
            :  |.:.|..|.:..|...|..:.:|..|..|:.:.|.....::|  |.|.| |:..||||||||
  Rat   726 V--TTSVPEVAVMEKILQKLTNMHKAYSPGKKISILLKTCKLIYDSMALGNP-GKPYGADDFLPV 787

  Fly  1872 LVYVVAKCGFVGAEIEAEFMWGLLQPTLLNGEPGYYLTALCSAVQVLKTF--------MASEGES 1928
            |:||:|:.......:..|:|..|:.|.|..||..||||....|::.:|.:        ::.|.:.
  Rat   788 LMYVLARSNLTEMLLNVEYMMELMDPALQLGEGSYYLTTTYGALEHIKNYDKITVTRQLSVEVQD 852

  Fly  1929 GSGSLDWRSSCLPA-----------CSSVLRVIIPDECNGSLQTRTLPVRPHTTTREVCRIIAHK 1982
            .....:.|.:...|           |.|.|:   |::     |:|||..|..|..:.:|...|.|
  Rat   853 SIHRWERRRTLNKARASRSSVQDFICVSYLQ---PEQ-----QSRTLASRADTVAQALCAQCAEK 909

  Fly  1983 ARITNPQDYALFKLVDGEETLLTDAECP 2010
            ..:..||||.||.||||....|.|...|
  Rat   910 FEVAQPQDYRLFVLVDGRCFQLADEALP 937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spri	NP_001259418.1	SH2	716..813	CDD:472789	30/98 (31%)
		VPS9	1824..1922	CDD:460489	36/107 (34%)
		RA_Rin	1946..2030	CDD:340474	24/65 (37%)
Rin3	NP_001401858.1	SH2_RIN3	52..153	CDD:198258	32/100 (32%)
		PHA03247	<244..562	CDD:223021	99/686 (14%)
		VPS9	736..839	CDD:460489	36/103 (35%)
		RA_Rin3	874..961	CDD:340547	26/72 (36%)