DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spri and Rin2

DIOPT Version :9

Sequence 1:	NP_001259418.1	Gene:	spri / 31987	FlyBaseID:	FBgn0085443	Length:	2043	Species:	Drosophila melanogaster
Sequence 2:	NP_001101256.1	Gene:	Rin2 / 311494	RGDID:	1305873	Length:	902	Species:	Rattus norvegicus

Alignment Length:	1406	Identity:	278/1406 - (19%)
Similarity:	430/1406 - (30%)	Gaps:	591/1406 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   660 ELSQSRTSLVSSSEGGILAEGETSSEDDEEEPVEAED-EGEESSRDSSDNSPPCDLGLMERLLVT 723
            |:.|:..||    |.| |...||.|....::....|| :|:...|||..:|....|.:::|||.|
  Rat    34 EMVQTDVSL----ENG-LEPSETYSMVRHKDGGYPEDKDGKTCPRDSGYDSLSNRLSILDRLLHT 93

  Fly   724 HPMWFLPGIQRSGAVHLLQGKEEGTFIVRGSSQPNTMAVSVRLPQDTGPYIEHYLIQSHDNVLSL 788
            ||:|....:....|..:||.:..|.|:||.||:.....:|:|||.:.|..::.:.|:......||
  Rat    94 HPIWLQLSLSEEEAAEVLQAQPPGIFLVRKSSKMQKKVLSLRLPCEFGAPLKEFTIKESTYTFSL 158

  Fly   789 ESSRFTFGSIPSLIAHYAQCCDELPVQLMLPRVLREANNRKKLSSLALLGQEFWSYVSSPALLGP 853
            |.|..:|..:..|||.|....|.||..|.||..:..|....:|..||.||..|||
  Rat   159 EGSGISFADLFRLIAFYCISRDVLPFTLKLPYAISTAKTESQLEELAQLGLNFWS---------- 213

  Fly   854 LTPSVAPSKDQQLLDAKSPLSLTETSGLGTATFFSDTVSKPPPTGAP--PLPGGGLFSPTGSGQL 916
                                              |...:|||.:..|  ||...|: .|....||
  Rat   214 ----------------------------------SSADNKPPNSPPPHRPLSSAGI-CPASLRQL 243

  Fly   917 L---GFFS-QAGTPSD----TTNSSLSSFTTSGGQHMQLLSPNSVDSVILTMSPVDNPGHYLPGS 973
            .   |..| :..|||:    .||.:|....
  Rat   244 CLINGVHSIKTRTPSELECSQTNGALCFIN----------------------------------- 273

  Fly   974 TGAPMAPLCPSVVDQQLSTFKVAQTAPEVDQVRPQRPKPPNTLNLKPPAPPLRWSKPHSPDQNGS 1038
                  ||...|..|.|||                .||.|:|               .:|:.||:
  Rat   274 ------PLFLKVHSQDLST----------------GPKRPST---------------RTPNANGT 301

  Fly  1039 ANGNFTVTTTVTFSMENGGGGGSGPTVGNGNGKFVEVTTPAASNPFNALLNGQASTFQTFAKRLS 1103
            ..
  Rat   302 ER--------------------------------------------------------------- 303

  Fly  1104 PEGECKDTLSSQGSSSNDSRWPPPARKLLTSPMTPLTPSGGSSSSGGKSRKSRAGKESQHYKESD 1168
                              .|.|||
  Rat   304 ------------------PRSPPP----------------------------------------- 309

  Fly  1169 ILESPPMQYCASALSDKISDYEDVWSHDPSDRASLLTSFRPALDTVGGVMNRRPDLLAETPSTPT 1233
              ..||                                  ||:::    ::..|.|....|.|..
  Rat   310 --RPPP----------------------------------PAINS----LHTSPGLSRTEPQTSM 334

  Fly  1234 PTQQSHLTPCEEETTATPNESSSQSLLQFSGDVPARSRAGLLLPNLSGQVPPVAMTKSMTAAEDD 1298
            |....|            ::..:.:||   |..|.             .:||..:
  Rat   335 PETVHH------------SKHGNVALL---GTKPT-------------PIPPPRL---------- 361

  Fly  1299 GGDTTPTAEGQANGASRSKQGSPFYAEPADALRQAGLTSAATAILRRQHRSQMLHASQRHSEPLK 1363
                             .||.|...||          :||.|....|..||
  Rat   362 -----------------KKQASFLEAE----------SSAKTLTACRPGRS-------------- 385

  Fly  1364 AGFGGSGNGAMLQPSDLEKLAGSLDELKPKPKVSQQQQQSQQQQQPTKRARNRIDHWQLDSSWEF 1428
                                       .|:|::                              |.
  Rat   386 ---------------------------PPEPEL------------------------------EL 393

  Fly  1429 MAKQDTGSHAGGDYDTAAIDWQEKENSLGRDSRADGQGKKRTLTIHQIIANRLPDLNLPELVRCS 1493
            ..:..|..||||              :..||:..|              ..|.|
  Rat   394 EVEMGTAGHAGG--------------APPRDAPGD--------------CTRAP----------- 419

  Fly  1494 TPPQTAALQPHVLGQDKAGVGCDGSQKSFQSQIGCRLSSYDNVFCQNSFGGIDSAQSDDGTIFSE 1558
             ||.:.:..|          .|.|:::        |||
  Rat   420 -PPDSESQPP----------PCHGARQ--------RLS--------------------------- 438

  Fly  1559 PWDSSQWDTFLPHDDATINSDTIHLSKCRPALS-EDDTIVEELQSTKDGSNGSCNQDTLKANRNG 1622
                   |..|    :|.:||::...:..|... |.||     .|:.:...|..:|:|:..
  Rat   439 -------DMSL----STSSSDSLEFDRSMPLYGYEADT-----TSSLEDYEGESDQETMAP---- 483

  Fly  1623 AGHHKLNNGNGNGKANNRPKVATILRNPSMRDREVLCHPRNKMS-IQSS--GPGDSLRAYTLQLA 1684
                              |..:...||.|....:::.....||| :.||  .|...:.....:|:
  Rat   484 ------------------PIKSKKKRNSSFVLPKLVKSQLRKMSGVFSSFMTPEKRMVRRIAELS 530

  Fly  1685 QDPSSTFARNIENFICCTKESRE--AAPQVVMRNMRQFMSGMKNYLVKHGEGKFHAELETARARL 1747
            :|..:.|...:::::...||::|  .:...:::.:||||:.:||||.:      .:||:.....|
  Rat   531 RDKCTYFGCLVQDYVSFLKENKECHVSSTDMLQTIRQFMTQVKNYLSQ------SSELDPPIESL 589

  Fly  1748 KSDEFLNLDAMLETVMHQLVVLPLREHLYGIFVDHYQRSEDIQLLAQNVRYACEREAADFGI-RP 1811
            ..::  .:|.:||..||:.::.||:.|:..:..|.:......:.|.:|::...:|...:.|: .|
  Rat   590 IPED--QIDVVLEKAMHKCILKPLKGHVEAMLKDFHTADGSWKQLKENLQLVRQRNPQELGVFAP 652

  Fly  1812 TVTPPSQAALRLIANLLWRLQEAELPLDKLELFLCVISTVFDATGCPRGQQLGADDFLPVLVYVV 1876
            |   |....|..|......:|:...|..|:.|.|.|...::.......|:..|||||||||.||:
  Rat   653 T---PDLMELEKIKLKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVI 714

  Fly  1877 AKCGFVGAEIEAEFMWGLLQPTLLNGEPGYYLTALCSAVQVLKTFMASE------GESGSGSLDW 1935
            |:|..:..:.|.|:|..||.|:||:||.|||||:...|:.::|.|...:      .|:......|
  Rat   715 AQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSEARDTLRQW 779

  Fly  1936 R-----SSCLPAC---SSVLRVIIPDECNGSLQTRTLPVRPHTTTREVCRIIAHKARITNPQDYA 1992
            .     :..:|:.   .:.|||.. .|.|.....:||.|||:.||.:||::.|.|.::.:|::|:
  Rat   780 HKRRTTNRTIPSVDDFQNYLRVAF-QEVNSGCTGKTLLVRPYITTEDVCQLCAEKFKVEDPEEYS 843

  Fly  1993 LFKLVDGEETLLTDAECPQDARLAAKGK---HCM-LAYKRI 2029
            ||..||.....|.:...||..:.....:   |.. ..||||
  Rat   844 LFLFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRI 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spri	NP_001259418.1	SH2	716..813	CDD:301589	32/96 (33%)
		VPS9	1821..1922	CDD:280383	39/100 (39%)
		UBQ	1946..2026	CDD:294102	26/83 (31%)
Rin2	NP_001101256.1	SH2_RIN2	86..185	CDD:198257	34/98 (35%)
		VPS9	658..774	CDD:128469	41/115 (36%)
		Rin1_RA	798..884	CDD:176371	28/86 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343783
Domainoid	1	1.000	76	1.000	Domainoid score	I8731
eggNOG	1	0.900	-	-		E1_KOG2320
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	243	1.000	Inparanoid score	I3221
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001291
OrthoInspector	1	1.000	-	-		otm46106
orthoMCL	1	0.900	-	-		OOG6_107356
Panther	1	1.100	-	-	O	PTHR23101
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2330
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.790