Protein Alignment spri and Vps9d1

DIOPT Version :10

• Sequence 1: NP_001259418.1
• Gene: spri / 31987
• FlyBaseID: FBgn0085443
• Length: 2043
• Species: Drosophila melanogaster
• Sequence 2: NP_001401867.1
• Gene: Vps9d1 / 307923
• RGDID: 1565149
• Length: 648
• Species: Rattus norvegicus
• Alignment Length: 808
• Identity: 154/808 - (19%)
• Similarity: 264/808 - (32%)
• Gaps: 262/808 - (32%)

  Fly  1175 MQYCASALSDKISDYEDVWSHDPSDRASLLTSFRPALD------TVGGVMNRRPDLLAETPSTPT 1233
            ::|.:..|.:.:.:..:.....|.:.:.:|......|:      |..|.:..:|.:.| .|..|.
  Rat    43 IRYISQVLLEDVENTTEAGETVPPETSKMLKLAEQCLERAQSTATKLGKICLKPAIPA-APPVPL 106

  Fly  1234 PTQQSHLTPCEEETTATPNESSSQSLLQFSGDVPARSRAGLLLPNLSGQVPPVAMTKSMTA-AED 1297
            |::  |...|.:|                         .|.|.|.|    ||....|...| :.:
  Rat   107 PSR--HRRVCSDE-------------------------GGKLSPFL----PPEIFQKLQVAESHN 140

  Fly  1298 DGGDTTPTAEGQANGASRSKQGSPFYA-----EPADALRQAGLTSAATAILRRQHRSQMLHASQR 1357
            ...:.||..:.   .....|..:.:.|     :|:.|:::..||.:    |:||....::.|..|
  Rat   141 SKKELTPLEKA---SLQNQKLRATYEARMARLDPSQAMQKTSLTLS----LQRQMMENLVIAKAR 198

  Fly  1358 HSEPLKAGFGGSGNGAMLQPSDLEKLAGSLDELKPKPKVSQQQQQSQQQQQPTKRARNRIDHWQL 1422
             .|.|:              ..:|:....|.|...:...||.....::::|....|  .|..::.
  Rat   199 -EETLQ--------------RKMEQRRLRLQEAANRRFCSQVALTPEEREQRALYA--AILEYEQ 246

  Fly  1423 DSSWEFMAKQDTGSHAGGDYDTAAIDWQEKENSLGRDSRADGQGKKRTLTIHQIIANRLPDLNLP 1487
            |..|.        .|           |:.|.      .|:.|.....|..:..:::  |||..:.
  Rat   247 DHDWP--------KH-----------WRAKL------KRSPGDLSLVTSLVSHLLS--LPDHPIS 284

  Fly  1488 ELVR-------------------CSTP-PQTAALQPHVLGQDKAGVGCDGSQKSFQSQ-IGCRLS 1531
            :|::                   |:.| |.:.:|.|     :..|:...||::...|| :.|.||
  Rat   285 QLLKKLQCAVYSALYPVVSRAAICAVPAPGSCSLPP-----EANGLLAPGSRRLRSSQSLYCMLS 344

  Fly  1532 SYDNVFCQNSFGGIDSAQS----DDGTIFSEPWDSSQWDTFLPHDDATINSDTIHLSKCRPALSE 1592
            ..:......:..|..|..|    ..||:..|.             |.:....:..|....|.|.:
  Rat   345 PSEPSAAPRALDGPPSTPSIPILHSGTLDREA-------------DGSPAGPSSPLVGALPHLPD 396

  Fly  1593 DDTIVEELQS----TKDGSNGS-------CNQDTLKANRNGAGHHKLNNGNGNGKANNRPKVATI 1646
            .|:..|:|:.    ::..:.|:       |.:.|:|...|               |.:|....|:
  Rat   397 KDSSFEDLEQFLAMSEPQTPGAKREPLLECLKSTVKDIHN---------------AIDRLLSLTL 446

  Fly  1647 LRNPSM-----RDREVLCHPRNKMSIQSSGPGDSLRAYTLQLAQDPSSTFARNIENFICCTKESR 1706
            |...|:     :||.:.|......|          ..:.|.||      ..|::.       .:|
  Rat   447 LAFESLNTATCKDRCLACIEEPFFS----------PLWPLLLA------LYRSVH-------RTR 488

  Fly  1707 EAAPQVVMRNMRQFMSGMKNYLVKHGEGKFHAELETARARLKSDEFLNLDAMLETVMHQLVVLPL 1771
            |||   |.|:|..:.:.                |.||         |.:...|         ||.
  Rat   489 EAA---VSRSMELYRNA----------------LPTA---------LGIPTKL---------LPC 516

  Fly  1772 REHLYGIFVDHYQRSEDIQLLAQNVRYACEREAADFGIRPTVTPPSQAALRLI---ANLLWRLQE 1833
            ..........:...::::.||   |..:|.::..:..:|         .||:|   |....|.||
  Rat   517 VPEAQASTYPYCTAAQELGLL---VLESCPQKKLECIVR---------TLRVICICAEDYCRAQE 569

  Fly  1834 AELPLDKLELFLCVISTVFDATGCPRGQQLGADDFLPVLVYVVAKCGFVGAEIEAEFMWGLLQPT 1898
            |. |               :....|....:||||.||:|.:||.:.|......|...:.......
  Rat   570 AR-P---------------EGGSQPPAAAIGADDLLPILSFVVLRSGLPQLVSECAALEEFTHEG 618

  Fly  1899 LLNGEPGYYLTALCSAVQVLKTFMASEG 1926
            .|.||.||.||:|.||:..::  :.|.|
  Rat   619 YLIGEEGYCLTSLQSALSYVE--LLSRG 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spri	NP_001259418.1	SH2	716..813	CDD:472789
		VPS9	1824..1922	CDD:460489	29/100 (29%)
		RA_Rin	1946..2030	CDD:340474
Vps9d1	NP_001401867.1	MIT	13..82	CDD:461228	5/38 (13%)
		VPS9	527..642	CDD:460489	36/144 (25%)