Protein Alignment spri and Rinl

DIOPT Version :10

• Sequence 1: NP_001259418.1
• Gene: spri / 31987
• FlyBaseID: FBgn0085443
• Length: 2043
• Species: Drosophila melanogaster
• Sequence 2: XP_006228715.1
• Gene: Rinl / 292760
• RGDID: 1310133
• Length: 672
• Species: Rattus norvegicus
• Alignment Length: 805
• Identity: 168/805 - (20%)
• Similarity: 262/805 - (32%)
• Gaps: 263/805 - (32%)

  Fly  1200 RASLLTSFRPALDTVGGVMNRRPD---LL----------------------AETPSTPTPTQQSH 1239
            |.||:| |.|         :.|||   ||                      |.:|::...:.::.
  Rat    11 RGSLVT-FHP---------DCRPDRGPLLQSGSLKNDPLEREEGDFKCPSPASSPASLASSLENT 65

  Fly  1240 LTPCEEETTATPNESSSQSLLQFSGDVP--ARSRAGLLLPNLSGQVPPVAMTKSMTAAEDDGGDT 1302
            .|.|   .:.:|..||..|.......:|  .|.:.|.|:|.            ||..|:.|....
  Rat    66 FTSC---CSGSPRNSSCPSWSSLESCLPPCQRPKHGSLVPG------------SMRLAQPDMVSA 115

  Fly  1303 TPTAEGQ-----ANGASRSKQGSPFYAEPADALRQAGLTSAATAILRRQHRSQMLHASQRHSEPL 1362
            ..|.|.:     |.||.:|            .||   :.|...::||.|...::....:..:|..
  Rat   116 ATTEEARLSWPLAEGADKS------------PLR---VLSTTESLLRLQRTQRVWQVPELDAEHA 165

  Fly  1363 KAGFGGSGNGAMLQPSDLEKLAGSLDELKPKPKVSQQQQQSQQQQQPTKRARNRIDHWQLDSSWE 1427
            ||                        .|||                           |.|.|.
  Rat   166 KA------------------------FLKP---------------------------WPLGSF-- 177

  Fly  1428 FMAKQD--------TGSHAGGDYDTAAIDWQEKENSLGRDSRADGQGKKRTLTIHQIIANR-LPD 1483
            .:..||        ||. :.||.:|..|  |:....:..:|                 :|. :||
  Rat   178 LVIGQDPDQVLMLKTGP-SSGDINTYQI--QKFPGGVSLES-----------------SNLCMPD 222

  Fly  1484 LNLPELVRCSTP-----PQTAALQPHVLGQDKAGVGCDGSQKSFQSQIGC-------RLSSYDNV 1536
              .|.|:...:.     |:|..|....:|        .|.:.|...::||       |:.|..|.
  Rat   223 --FPHLLAFLSASRDVLPRTLLLPTPTVG--------PGDKHSDPRRLGCIQVDTSGRVLSVVNQ 277

  Fly  1537 FCQNSFGGIDSAQSDDGTIFSEPWDSSQWDTFLPHDDATINSDTIHLSKCRPALSEDDTIVEELQ 1601
            ....:.||                    |:|..|............|:...|.......:.|.|:
  Rat   278 LYLETHGG--------------------WETETPQQTKPETGQKRSLAPRMPTPHRVSWVEESLK 322

  Fly  1602 STKDGSNGSCNQDTLKANRNGAGHHKLNNGNGNGKANNRPKV---ATIL------RNPSMRDREV 1657
            .....:....:....:.:..|...|.|.           |:|   :.:|      .|.|.:|.|.
  Rat   323 PEAHHTGQEVHHPERQVHYPGPEAHSLG-----------PEVHFPSPVLEEEEEVNNDSYKDEEE 376

  Fly  1658 LCHPRNKMSIQSSGPGDSLRAYTLQLAQDPSSTFARNIENFICCTKE---SREAAP-------QV 1712
            .|.             |.|.|:...||...||..||..:    |.:.   |....|       ..
  Rat   377 GCE-------------DMLTAHIRALASARSSYVARQYQ----CLRARLISDSGNPYSPGDPATE 424

  Fly  1713 VMRNMRQFMSGMKNYLVKHGEGKFHAELETARARLKSDEFLNLDAMLETVMHQLVVLPLREHLYG 1777
            :::::||.::.:::||.|  :....|........:..:|  :|...:|..:.:.|:.||:..|:
  Rat   425 LLQDVRQLLTDLQDYLAK--DPDVRAVFGNRGPSIPREE--DLGPAVEVALCRAVLEPLKPALW- 484

  Fly  1778 IFVDHYQRSEDIQLLAQNVRYACEREAADFGIRPTVTPPSQA-ALR-LIANLLWRLQEAELPLDK 1840
                    ::...|.||.:|....|:.|   :|....|..|: ||| .|...|..|..|..|..|
  Rat   485 --------TKLRTLRAQELRRLRRRQIA---LRVGAGPEGQSPALRNRIHARLAHLHAACAPRRK 538

  Fly  1841 LELFLCVISTVF-DATGCPRGQQLGADDFLPVLVYVVAKCGFVG-AEIEAEFMWGLLQPTLLNGE 1903
            :.|.|.|.|.|: ...|....:.||||.|||.|...:.....:| .:::.||:..||.|..|.||
  Rat   539 VALLLAVCSDVYAGLAGGENKEPLGADAFLPALTEELIWSPHIGETQLDVEFLMELLDPGELRGE 603

  Fly  1904 PGYYLTALCSAVQVLKTFMASEGES 1928
            .|||||....|:..:..:....|.:
  Rat   604 AGYYLTTWFGALYHIAHYQPDAGRA 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spri	NP_001259418.1	SH2	716..813	CDD:472789
		VPS9	1824..1922	CDD:460489	35/99 (35%)
		RA_Rin	1946..2030	CDD:340474
Rinl	XP_006228715.1	SH2	147..240	CDD:472789	27/167 (16%)
		VPS9	521..623	CDD:460489	35/101 (35%)