DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spri and Rin1

DIOPT Version :9

Sequence 1:	NP_001259418.1	Gene:	spri / 31987	FlyBaseID:	FBgn0085443	Length:	2043	Species:	Drosophila melanogaster
Sequence 2:	XP_006531773.1	Gene:	Rin1 / 225870	MGIID:	2385695	Length:	798	Species:	Mus musculus

Alignment Length:	1424	Identity:	247/1424 - (17%)
Similarity:	362/1424 - (25%)	Gaps:	787/1424 - (55%)

- Green bases have known domain annotations that are detailed below.

  Fly   686 DDEEEPVE---AEDEGE------------------ESSRDSSD----------------NSPPCD 713
            :.:|:|.|   .||.||                  :..:.|:|                ..|...
Mouse    14 ESQEKPKELPAMEDPGETGAHPLGATNLNFVPGHQQKEKPSTDPLYDTPDTRGVQAGGSQQPART 78

  Fly   714 LGLMERLLVTHPMWFLPGIQRSGAVHLLQGKEEGTFIVRGSSQPNTMAVSVRLPQDTGPYI--EH 776
            :.|.||||:|.|:|.......:.|:|:|:.:..|||:||.|:.....|:.||||:.:||..  .|
Mouse    79 VSLRERLLITRPVWLQLRANAAAALHVLRTEPPGTFLVRKSNTRQCQALCVRLPEASGPSFVSSH 143

  Fly   777 YLIQSHDNVLSLESSRFTFGSIPSLIAHYAQCCDELPVQLMLPRVLREANNRKKLSSLALLGQEF 841
            |:.:|...| |||.|...|..:..||..|.:..|.|.:.|.|||.:.:|...|:|.:::.||.||
Mouse   144 YIEESTGGV-SLEGSELMFQDLVQLICGYCRTRDILLLPLRLPRAIHQAATHKELEAISHLGMEF 207

  Fly   842 WSYVSSPALLGPLTPSVAPSKDQQLLDAKSPLSLTETSGLGTATFFSDTVSKPPPTGAPPLPGGG 906
            ||             |...:||||                             .|:.|||:|...
Mouse   208 WS-------------SSLNTKDQQ-----------------------------RPSEAPPIPRLK 230

  Fly   907 LFSP----TGSGQLLGFFSQAGTPSDTTNSSLSSFTTSGGQHMQLLSPNSVDSVILTMSPVDNPG 967
            ..||    .|:|..|.||                                            ||
Mouse   231 ARSPQELDQGTGAALCFF--------------------------------------------NP- 250

  Fly   968 HYLPGSTGAPMAPLCPSVVDQQLSTFKVAQTAPEVDQVRPQRPKPPNTLNLKPPAPPLRWSKPHS 1032
             ..||..|       |:..::...:|||        :|..:...|     |.|||.|
Mouse   251 -LFPGDLG-------PTKREKFKRSFKV--------RVSTETSSP-----LSPPAVP-------- 286

  Fly  1033 PDQNGSANGNFTVTTTVTFSMENGGGGGSGPTVGNGNGKFVEVTTPAASNPFNALLNGQASTFQT 1097

Mouse   287 ----------------------------------------------------------------- 286

  Fly  1098 FAKRLSPEGECKDTLSSQGSSSNDSRWPPPARKLLTSPMTPLTPSGGSSSSGGKSRKSRAGKESQ 1162
                                       |||         .|:.|  |:|||
Mouse   287 ---------------------------PPP---------VPVLP--GTSSS-------------- 299

  Fly  1163 HYKESDILESPPMQYCASALSDKISDYEDVWSHDPSDRASLLTSFRPALDTVGGVMNRRPDLLAE 1227
               :::.|  ||.|                                               ||..
Mouse   300 ---QTERL--PPRQ-----------------------------------------------LLQR 312

  Fly  1228 TPSTPTPTQQSHLTPCEEETTATPNESSSQSLLQFSGDVPARSRAGLLLPNLSGQVPPVAMTK-- 1290
            ..|.......|..:||                                       :||:...:
Mouse   313 ESSVGYRVPGSAASPC---------------------------------------LPPLPSLQEV 338

  Fly  1291 ---SMTAAEDDGGDTTPTAEGQANGASRSKQGSPFYAEPADALRQAGLTSAATAILRRQHRSQML 1352
               |.:::|::|...:||.             ||..:.|
Mouse   339 DCCSPSSSEEEGSSGSPTT-------------SPRLSRP-------------------------- 364

  Fly  1353 HASQRHSEPLKAGFGGSGNGAMLQPSDLEKLAGSLDELKPKPKVSQQQQQSQQQQQPTKRARNRI 1417
                ||..||
Mouse   365 ----RHRRPL------------------------------------------------------- 370

  Fly  1418 DHWQLDSSWEFMAKQDTGSHAGGDYDTAAIDWQEKENSLGRDSRADGQGKKRTLTIHQIIANRLP 1482

Mouse   371 ----------------------------------------------------------------- 370

  Fly  1483 DLNLPELVRCSTPPQTAALQPHVLGQDKAGVGCDGSQKSFQSQIGCRLSSYDNVFCQNSFGGIDS 1547
                                                           |.|..:.||
Mouse   371 -----------------------------------------------LRSMSSAFC--------- 379

  Fly  1548 AQSDDGTIFSEPWDSSQWDTFLPHDDATINSDTIHLSKCRPALSEDDTIVEELQSTKDGSNGSCN 1612

Mouse   380 ----------------------------------------------------------------- 379

  Fly  1613 QDTLKANRNGAGHHKLNNGNGNGKANNRPKVATILRNPSMRDREVLCHPRNKMSIQSSGPGDSLR 1677
              :|.|.....|                 :.||:|    |::|
Mouse   380 --SLLAPERQVG-----------------RAATML----MQNR---------------------- 399

  Fly  1678 AYTL--QLAQDPSSTFARNIENFICCTKESREAAPQVVMRNMRQFMSGMKNYLVKHGEGKFHAEL 1740
             ||.  ||.||        :...:....|.||      ::.:||.:|..:..|
Mouse   400 -YTAVGQLVQD--------LLTQVRAGPEPRE------LQGIRQALSRARAML------------ 437

  Fly  1741 ETARARLKSDEFL---NLDAMLETVMHQLVVLPLREHLYGIFVDHYQRSEDIQLLAQNVRYACER 1802
               .|.|..::.|   .|:.:||..:|:.|:.|||..|.............:..||:..|.|..:
Mouse   438 ---SAELGPEKLLPPERLELVLEKSLHRSVLKPLRPILAARLRRRLSADGSLGRLAEGFRLARTQ 499

  Fly  1803 EAADFGIRPTVTPP------SQAALRLI------ANLLWRLQEAELPLDKLELFLCVISTVFDAT 1855
            ....||...|::.|      .|..|:|:      |.:.|.||..:|              ::.|.
Mouse   500 GPGAFGSHLTLSSPVETEQVRQKLLQLLRAYSPSAQVKWLLQACKL--------------LYTAL 550

  Fly  1856 GCPRGQQLGADDFLPVLVYVVAKCGFVGAEIEAEFMWGLLQPTLLNGEPGYYLTALCSAVQVL-- 1918
            ....|:..|||:|||:|..|:|:|......:|||:|..||:||||.||.|||||:|.:::.:|
Mouse   551 KSQAGENAGADEFLPLLSLVLAQCDLPDLLLEAEYMSELLEPTLLTGEGGYYLTSLSASLALLSG 615

  Fly  1919 ----KTFMASEGESGSGSLD-WRSSCLPACSS---VLRVIIPDECNGSLQTRTLPVRPHTTTREV 1975
                :....|..:....||. |....|||..|   :|||...|...| ..::||.|.|.::...:
Mouse   616 LSQARALPLSPAQELQRSLALWEQRRLPATHSFQHLLRVAYQDPSTG-CTSKTLAVPPGSSIATL 679

  Fly  1976 CRIIAHKARITNPQDYALFKLVD-GEETLLTDAECPQDA---RLAAKGKHCMLAYKRID 2030
            .::.|.|.|:|.|..:.||...| |...|      |.:|   ||.|.|   .|.|:|.:
Mouse   680 SQLCATKFRVTQPDAFGLFLYKDQGYHRL------PPEALAHRLPATG---YLIYRRAE 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spri	NP_001259418.1	SH2	716..813	CDD:301589	37/98 (38%)
		VPS9	1821..1922	CDD:280383	38/112 (34%)
		UBQ	1946..2026	CDD:294102	26/83 (31%)
Rin1	XP_006531773.1	SH2_RIN1	81..177	CDD:198256	36/96 (38%)
		VPS9	513..631	CDD:128469	41/131 (31%)
		Ubiquitin_like_fold	649..729	CDD:391949	28/89 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839930
Domainoid	1	1.000	76	1.000	Domainoid score	I8927
eggNOG	1	0.900	-	-		E1_KOG2320
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001291
OrthoInspector	1	1.000	-	-		otm44014
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23101
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3144
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.870