DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment spri and Rin3

DIOPT Version :9

Sequence 1:NP_001259418.1 Gene:spri / 31987 FlyBaseID:FBgn0085443 Length:2043 Species:Drosophila melanogaster
Sequence 2:NP_808288.2 Gene:Rin3 / 217835 MGIID:2385708 Length:980 Species:Mus musculus


Alignment Length:1390 Identity:284/1390 - (20%)
Similarity:445/1390 - (32%) Gaps:499/1390 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   665 RTSLVSSSE--GGILAEGETSSEDDEEEPVEAEDEGEESSRDSSDNS--PPCDLGLMERLLVTHP 725
            |....||:.  |.|...|:...|:|||:      :|......::..:  |...:.::|:|:.|.|
Mouse     3 RAEAPSSAHPAGPIPDAGKGEGEEDEEK------DGTRLGLSTTPRNCIPRRGISVLEKLVKTCP 61

  Fly   726 MWFLPGIQRSGAVHLLQGKEEGTFIVRGSSQPNTMAVSVRLPQDTGPYIE--HYLIQSHDNVLSL 788
            :|...|:.::.|..:||.:..|.|:|...:....:.:.|..|...|...|  .|.|:....:|.|
Mouse    62 VWLQLGLGQAEAAKILQQEMAGMFLVCRDNNLKQLVLCVHFPSLKGSSAEVLEYPIKEEKAILYL 126

  Fly   789 ESSRFTFGSIPSLIAHYAQCCDELPVQLMLPRVLREANNRKKLSSLALLGQEFW-SYVSSPALLG 852
            |.|...|..|..|||.|....|.||..|.||:.:.||::..:|.:::.||..|| |.::|.....
Mouse   127 EGSVLVFEDIFRLIAFYCVSRDLLPFTLRLPQAILEASSFLELETISNLGLGFWDSSLNSRGSAE 191

  Fly   853 PLTPSVAPSKDQQLLDAKSPLSLTETSGLGTATFFSDTVSKPPPTGAPPLPGGGLFSPTGSGQLL 917
            ||               :||                          ||..|......||      
Mouse   192 PL---------------RSP--------------------------APGTPASSSLRPT------ 209

  Fly   918 GFFSQAGTPSDTTNSSLSSFTTSGGQHMQLLSPNSVDSVILTMSPVDNP-GHYLPGSTGAPMAPL 981
                     :...|.|.....:.|...:..::|..::..||...|...| |.|.|..|       
Mouse   210 ---------THYANCSCEIELSVGNDRLWFVNPIFIEDCILPADPPPLPTGSYPPRPT------- 258

  Fly   982 CPSVVDQQLSTFKVAQTAPEVDQVRPQRPKPPNTLNLKPPAPPLRWSKPHSPDQNGSANGNFTVT 1046
             |:..|....|.|.:          |:||.||..|...||..|.|...|..|......|...|.|
Mouse   259 -PATPDATSPTSKGS----------PRRPPPPPPLPTVPPTGPARPLAPPVPPAGPLPNSPLTPT 312

  Fly  1047 TTVTFSMENGGGGGSGPTVGNGNGKFVEVTTPAASN--PFNALLNGQASTFQTFAKRLSPEGECK 1109
            :.:       .....||              |..||  |..|     ..:....|..|.|.||.:
Mouse   313 SHL-------APHAPGP--------------PGHSNQPPMTA-----CESLPRPAVGLGPFGEEE 351

  Fly  1110 DTLSSQGSSSNDSRWPPPARKLLTSPMTPLTPSGGSSSSGGKSRKSRAGKESQHYKESDILESPP 1174
               ...|::.|.....||       |..||                          :..:..:||
Mouse   352 ---MKPGTTPNPLHQAPP-------PPLPL--------------------------KKALPAAPP 380

  Fly  1175 MQYCASALSDKISDYEDVWSHDPSDRASLLTSFRPALDTVGGVMNRRPDLLAETPSTPTPTQQSH 1239
            .:..                   |:|.||                       |:.:..|.|.:.|
Mouse   381 RRRI-------------------SERVSL-----------------------ESQNVGTSTDRDH 403

  Fly  1240 LTPCEEETTATPNESSSQSLLQFSGDVPARSRAGLLLPNLSGQVPPVAMTKSM-TAAEDDGGDTT 1303
            .......:...|.:|:..||                     |..||....:|. |.|:....|:.
Mouse   404 SGISRTASLNLPPQSTVSSL---------------------GDRPPRTTEQSQDTEAKASHADSI 447

  Fly  1304 PTAEGQANGASRSKQGSPFYAEPADALRQAGLTSAATAILRRQHRSQMLHASQRHSEPLKAGFGG 1368
            |...|:|      ||      .|....|:..::        ||..|.:|       .||:     
Mouse   448 PVPPGKA------KQ------PPVPPPRKKRVS--------RQLASTLL-------SPLE----- 480

  Fly  1369 SGNGAMLQPSDLEKLA--GSLDELKPKPKVSQQQQQSQQQQQPTKRARNRIDHWQLDSSWEFMAK 1431
                :.:|.:..||.|  .|.:.|.|..:...|..|.|....|             .||.||   
Mouse   481 ----SPIQEASSEKQATGASWEGLSPVRQAGMQHLQVQSSSCP-------------QSSPEF--- 525

  Fly  1432 QDTGSHAGGDYDTAAIDWQEKENSLGRDSRADGQGKKRTLTIHQIIANRLPDLNLPELVRCSTPP 1496
                                                                             
Mouse   526 ----------------------------------------------------------------- 525

  Fly  1497 QTAALQPHVLGQDKAGVGCDGSQKSFQSQIGCRLSSYDNVFCQNSFGGIDSAQSDDGTIFSEPWD 1561
                               .|||.|....:|...|:.|    |:|:   .::.:::...||.|  
Mouse   526 -------------------KGSQASLSDSLGVPASAAD----QDSY---STSSAEEELEFSSP-- 562

  Fly  1562 SSQWDTFLPHDDATINSDTIHLSKCRPALSEDDTIVEELQSTKDGSNGSCNQDTLKANRNGAGHH 1626
                                                                             
Mouse   563 ----------------------------------------------------------------- 562

  Fly  1627 KLNNGNGNGKANNRPKVATILRNPSMRDREVLCHPRNKMSIQSSGP------GDSLRAY--TLQL 1683
                              .:.:.|||    :|...|:::|..|...      ....:.|  .::|
Mouse   563 ------------------NVKKKPSM----ILDKARHRLSFVSFASVFHAFLSSDRKLYKKVVEL 605

  Fly  1684 AQDPSSTFARNIENFICCTKE--SREAAPQVVMRNMRQFMSGMKNYLVKHGEGKFHAELETARAR 1746
            |||.||.|...::::...:.|  :|:.:...:::.:|..|:.:|:||::..|.|...|     ..
Mouse   606 AQDKSSYFGSLVQDYKVYSLEMMARQTSSTEMLQEIRTMMTQLKSYLLQSTELKALVE-----PT 665

  Fly  1747 LKSDEFLNLDAMLETVMHQLVVLPLREHLYGIFVDHYQRSEDIQLLAQNVRYACEREAADFGIRP 1811
            |.|:|  .|:|::|:.:::.|:.||:|.:....::.:.|...:|.|.:|..........|.|:  
Mouse   666 LHSEE--ELEAIVESALYKCVLKPLKEAINSSLLEIHSRDGSLQQLKENQLVVLATTTTDLGV-- 726

  Fly  1812 TVTPPSQAALRLIANLLWRLQEAELPLDKLELFLCVISTVFD--ATGCPRGQQLGADDFLPVLVY 1874
            |.:.|..|.:..|...|..:.:|..|..|:.:.|.....::|  |.|.| |:..|||||||||:|
Mouse   727 TTSVPEVAVMEKILQKLTSMHKAYSPGKKISILLKTCKLIYDSMALGNP-GKPYGADDFLPVLMY 790

  Fly  1875 VVAKCGFVGAEIEAEFMWGLLQPTLLNGEPGYYLTALCSAVQVLKTF--------MASEGESGSG 1931
            |:|:.......:..|:|..|:.|.|..||..||||....|::.:|.:        ::.|.:....
Mouse   791 VLARSNLTEMLLNVEYMMELMDPALQLGEGSYYLTTTYGALEHIKNYDKITVTRQLSVEVQDSIH 855

  Fly  1932 SLDWRSSCLPA-----------CSSVLRVIIPDECNGSLQTRTLPVRPHTTTREVCRIIAHKARI 1985
            ..:.|.:...|           |.|.|:   |::     |:|||..|..|..:.:|...|.|..:
Mouse   856 RWERRRTLNKARASRSSVQDFICVSYLK---PEQ-----QSRTLASRADTAAQALCAQCAEKFEV 912

  Fly  1986 TNPQDYALFKLVDGEETLLTDAECP 2010
            :.||||.||.||||....|.|...|
Mouse   913 SQPQDYRLFVLVDGRCFQLADEALP 937

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
spriNP_001259418.1 SH2 716..813 CDD:301589 29/98 (30%)
VPS9 1821..1922 CDD:280383 36/110 (33%)
UBQ 1946..2026 CDD:294102 24/65 (37%)
Rin3NP_808288.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40 11/42 (26%)
SH2_RIN3 52..153 CDD:198258 31/100 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 247..496 81/427 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 509..560 17/157 (11%)
Interaction with RAB5B. /evidence=ECO:0000250 584..729 35/153 (23%)
VPS9 737..839 CDD:280383 36/102 (35%)
UBQ 888..958 CDD:294102 21/50 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167839932
Domainoid 1 1.000 76 1.000 Domainoid score I8927
eggNOG 1 0.900 - - E1_KOG2320
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 244 1.000 Inparanoid score I3280
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001291
OrthoInspector 1 1.000 - - otm44014
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23101
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2330
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
109.890

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