Protein Alignment spri and Rin3

DIOPT Version :10

• Sequence 1: NP_001259418.1
• Gene: spri / 31987
• FlyBaseID: FBgn0085443
• Length: 2043
• Species: Drosophila melanogaster
• Sequence 2: NP_808288.2
• Gene: Rin3 / 217835
• MGIID: 2385708
• Length: 980
• Species: Mus musculus
• Alignment Length: 1390
• Identity: 284/1390 - (20%)
• Similarity: 445/1390 - (32%)
• Gaps: 499/1390 - (35%)

  Fly   665 RTSLVSSSE--GGILAEGETSSEDDEEEPVEAEDEGEESSRDSSDNS--PPCDLGLMERLLVTHP 725
            |....||:.  |.|...|:...|:|||:      :|......::..:  |...:.::|:|:.|.|
Mouse     3 RAEAPSSAHPAGPIPDAGKGEGEEDEEK------DGTRLGLSTTPRNCIPRRGISVLEKLVKTCP 61

  Fly   726 MWFLPGIQRSGAVHLLQGKEEGTFIVRGSSQPNTMAVSVRLPQDTGPYIE--HYLIQSHDNVLSL 788
            :|...|:.::.|..:||.:..|.|:|...:....:.:.|..|...|...|  .|.|:....:|.|
Mouse    62 VWLQLGLGQAEAAKILQQEMAGMFLVCRDNNLKQLVLCVHFPSLKGSSAEVLEYPIKEEKAILYL 126

  Fly   789 ESSRFTFGSIPSLIAHYAQCCDELPVQLMLPRVLREANNRKKLSSLALLGQEFW-SYVSSPALLG 852
            |.|...|..|..|||.|....|.||..|.||:.:.||::..:|.:::.||..|| |.::|.....
Mouse   127 EGSVLVFEDIFRLIAFYCVSRDLLPFTLRLPQAILEASSFLELETISNLGLGFWDSSLNSRGSAE 191

  Fly   853 PLTPSVAPSKDQQLLDAKSPLSLTETSGLGTATFFSDTVSKPPPTGAPPLPGGGLFSPTGSGQLL 917
            ||               :||                          ||..|......||
Mouse   192 PL---------------RSP--------------------------APGTPASSSLRPT------ 209

  Fly   918 GFFSQAGTPSDTTNSSLSSFTTSGGQHMQLLSPNSVDSVILTMSPVDNP-GHYLPGSTGAPMAPL 981
                     :...|.|.....:.|...:..::|..::..||...|...| |.|.|..|
Mouse   210 ---------THYANCSCEIELSVGNDRLWFVNPIFIEDCILPADPPPLPTGSYPPRPT------- 258

  Fly   982 CPSVVDQQLSTFKVAQTAPEVDQVRPQRPKPPNTLNLKPPAPPLRWSKPHSPDQNGSANGNFTVT 1046
             |:..|....|.|.:          |:||.||..|...||..|.|...|..|......|...|.|
Mouse   259 -PATPDATSPTSKGS----------PRRPPPPPPLPTVPPTGPARPLAPPVPPAGPLPNSPLTPT 312

  Fly  1047 TTVTFSMENGGGGGSGPTVGNGNGKFVEVTTPAASN--PFNALLNGQASTFQTFAKRLSPEGECK 1109
            :.:       .....||              |..||  |..|     ..:....|..|.|.||.:
Mouse   313 SHL-------APHAPGP--------------PGHSNQPPMTA-----CESLPRPAVGLGPFGEEE 351

  Fly  1110 DTLSSQGSSSNDSRWPPPARKLLTSPMTPLTPSGGSSSSGGKSRKSRAGKESQHYKESDILESPP 1174
               ...|::.|.....||       |..||                          :..:..:||
Mouse   352 ---MKPGTTPNPLHQAPP-------PPLPL--------------------------KKALPAAPP 380

  Fly  1175 MQYCASALSDKISDYEDVWSHDPSDRASLLTSFRPALDTVGGVMNRRPDLLAETPSTPTPTQQSH 1239
            .:..                   |:|.||                       |:.:..|.|.:.|
Mouse   381 RRRI-------------------SERVSL-----------------------ESQNVGTSTDRDH 403

  Fly  1240 LTPCEEETTATPNESSSQSLLQFSGDVPARSRAGLLLPNLSGQVPPVAMTKSM-TAAEDDGGDTT 1303
            .......:...|.:|:..||                     |..||....:|. |.|:....|:.
Mouse   404 SGISRTASLNLPPQSTVSSL---------------------GDRPPRTTEQSQDTEAKASHADSI 447

  Fly  1304 PTAEGQANGASRSKQGSPFYAEPADALRQAGLTSAATAILRRQHRSQMLHASQRHSEPLKAGFGG 1368
            |...|:|      ||      .|....|:..::        ||..|.:|       .||:
Mouse   448 PVPPGKA------KQ------PPVPPPRKKRVS--------RQLASTLL-------SPLE----- 480

  Fly  1369 SGNGAMLQPSDLEKLA--GSLDELKPKPKVSQQQQQSQQQQQPTKRARNRIDHWQLDSSWEFMAK 1431
                :.:|.:..||.|  .|.:.|.|..:...|..|.|....|             .||.||
Mouse   481 ----SPIQEASSEKQATGASWEGLSPVRQAGMQHLQVQSSSCP-------------QSSPEF--- 525

  Fly  1432 QDTGSHAGGDYDTAAIDWQEKENSLGRDSRADGQGKKRTLTIHQIIANRLPDLNLPELVRCSTPP 1496
                                                                             
Mouse   526 ----------------------------------------------------------------- 525

  Fly  1497 QTAALQPHVLGQDKAGVGCDGSQKSFQSQIGCRLSSYDNVFCQNSFGGIDSAQSDDGTIFSEPWD 1561
                               .|||.|....:|...|:.|    |:|:   .::.:::...||.|
Mouse   526 -------------------KGSQASLSDSLGVPASAAD----QDSY---STSSAEEELEFSSP-- 562

  Fly  1562 SSQWDTFLPHDDATINSDTIHLSKCRPALSEDDTIVEELQSTKDGSNGSCNQDTLKANRNGAGHH 1626
                                                                             
Mouse   563 ----------------------------------------------------------------- 562

  Fly  1627 KLNNGNGNGKANNRPKVATILRNPSMRDREVLCHPRNKMSIQSSGP------GDSLRAY--TLQL 1683
                              .:.:.|||    :|...|:::|..|...      ....:.|  .::|
Mouse   563 ------------------NVKKKPSM----ILDKARHRLSFVSFASVFHAFLSSDRKLYKKVVEL 605

  Fly  1684 AQDPSSTFARNIENFICCTKE--SREAAPQVVMRNMRQFMSGMKNYLVKHGEGKFHAELETARAR 1746
            |||.||.|...::::...:.|  :|:.:...:::.:|..|:.:|:||::..|.|...|     ..
Mouse   606 AQDKSSYFGSLVQDYKVYSLEMMARQTSSTEMLQEIRTMMTQLKSYLLQSTELKALVE-----PT 665

  Fly  1747 LKSDEFLNLDAMLETVMHQLVVLPLREHLYGIFVDHYQRSEDIQLLAQNVRYACEREAADFGIRP 1811
            |.|:|  .|:|::|:.:::.|:.||:|.:....::.:.|...:|.|.:|..........|.|:
Mouse   666 LHSEE--ELEAIVESALYKCVLKPLKEAINSSLLEIHSRDGSLQQLKENQLVVLATTTTDLGV-- 726

  Fly  1812 TVTPPSQAALRLIANLLWRLQEAELPLDKLELFLCVISTVFD--ATGCPRGQQLGADDFLPVLVY 1874
            |.:.|..|.:..|...|..:.:|..|..|:.:.|.....::|  |.|.| |:..|||||||||:|
Mouse   727 TTSVPEVAVMEKILQKLTSMHKAYSPGKKISILLKTCKLIYDSMALGNP-GKPYGADDFLPVLMY 790

  Fly  1875 VVAKCGFVGAEIEAEFMWGLLQPTLLNGEPGYYLTALCSAVQVLKTF--------MASEGESGSG 1931
            |:|:.......:..|:|..|:.|.|..||..||||....|::.:|.:        ::.|.:....
Mouse   791 VLARSNLTEMLLNVEYMMELMDPALQLGEGSYYLTTTYGALEHIKNYDKITVTRQLSVEVQDSIH 855

  Fly  1932 SLDWRSSCLPA-----------CSSVLRVIIPDECNGSLQTRTLPVRPHTTTREVCRIIAHKARI 1985
            ..:.|.:...|           |.|.|:   |::     |:|||..|..|..:.:|...|.|..:
Mouse   856 RWERRRTLNKARASRSSVQDFICVSYLK---PEQ-----QSRTLASRADTAAQALCAQCAEKFEV 912

  Fly  1986 TNPQDYALFKLVDGEETLLTDAECP 2010
            :.||||.||.||||....|.|...|
Mouse   913 SQPQDYRLFVLVDGRCFQLADEALP 937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spri	NP_001259418.1	SH2	716..813	CDD:472789	29/98 (30%)
		VPS9	1824..1922	CDD:460489	36/107 (34%)
		RA_Rin	1946..2030	CDD:340474	24/65 (37%)
Rin3	NP_808288.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40		11/42 (26%)
		SH2_RIN3	52..153	CDD:198258	31/100 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	247..496		81/427 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	509..560		17/157 (11%)
		Interaction with RAB5B. /evidence=ECO:0000250	584..729		35/153 (23%)
		VPS9	736..839	CDD:460489	36/103 (35%)
		Ubl1_cv_Nsp3_N-like	874..961	CDD:475130	26/72 (36%)