Protein Alignment spri and Rin1

DIOPT Version :10

• Sequence 1: NP_001259418.1
• Gene: spri / 31987
• FlyBaseID: FBgn0085443
• Length: 2043
• Species: Drosophila melanogaster
• Sequence 2: NP_620607.2
• Gene: Rin1 / 207119
• RGDID: 620006
• Length: 798
• Species: Rattus norvegicus
• Alignment Length: 1403
• Identity: 249/1403 - (17%)
• Similarity: 366/1403 - (26%)
• Gaps: 742/1403 - (52%)

  Fly   689 EEPVEAE---------------DEGEESSRD-------------SSDNSPPCDLGLMERLLVTHP 725
            |:|.|.|               .:.|:.|.|             .....|...:.|.||||:|.|
  Rat    26 EDPGETEAHPLGATSLNFVPGYQQEEKPSPDPLYDTPDARGVQAGGSQQPARTVSLRERLLITRP 90

  Fly   726 MWFLPGIQRSGAVHLLQGKEEGTFIVRGSSQPNTMAVSVRLPQDTGP-YIEHYLIQSHDNVLSLE 789
            :|.......:.|:|:|:.:..|||:||.|:......:.||||:.:|| ::..:.:|.....:|||
  Rat    91 VWLQLRANAAAALHVLRTEPPGTFLVRKSNTRQCQTLCVRLPEASGPSFVSSHYLQESPGGISLE 155

  Fly   790 SSRFTFGSIPSLIAHYAQCCDELPVQLMLPRVLREANNRKKLSSLALLGQEFWSYVSSPALLGPL 854
            .|..||..:..||..|....|.|.:.|.|||.:.:|...|:|.:::.||.||||  ||.......
  Rat   156 GSELTFPDLVQLICAYCHTRDILLLPLRLPRAIHQAATHKELEAISHLGMEFWS--SSLNTKNQQ 218

  Fly   855 TPSVAPSKDQQLLDAKSPLSLTETSGLGTATFFSDTVSKPPPTGAPPLPGGGLFSPTGSGQLLGF 919
            .||.||...:  |.|:||..|.:                                  |:|..|.|
  Rat   219 RPSEAPQIPR--LKARSPQELDQ----------------------------------GTGAALCF 247

  Fly   920 FSQAGTPSDTTNSSLSSFTTSGGQHMQLLSPNSVDSVILTMSPVDNPGHYLPGSTGAPMAPLCPS 984
            |                                            ||  ..||..|       |:
  Rat   248 F--------------------------------------------NP--LFPGDLG-------PT 259

  Fly   985 VVDQQLSTFKVAQTAPEVDQVRPQRPKPPNTLNLKPPAPPLRWSKPHSPDQNGSANGNFTVTTTV 1049
            ..::...:|||        :|..:...|     |.|||.|
  Rat   260 KREKFKRSFKV--------RVSTETSSP-----LSPPAVP------------------------- 286

  Fly  1050 TFSMENGGGGGSGPTVGNGNGKFVEVTTPAASNPFNALLNGQASTFQTFAKRLSPEGECKDTLSS 1114
                                                                             
  Rat   287 ----------------------------------------------------------------- 286

  Fly  1115 QGSSSNDSRWPPPARKLLTSPMTPLTPSGGSSSSGGKSRKSRAGKESQHYKESDILESPPMQYCA 1179
                      |||         .|:.|  |:|||                 :::.|  ||
  Rat   287 ----------PPP---------VPVLP--GTSSS-----------------QTERL--PP----- 306

  Fly  1180 SALSDKISDYEDVWSHDPSDRASLLTSFRPALDTVGGVMNRRPDLLAETPSTPTPTQQSHLTPCE 1244
                                        |..|.....|..|.|. .|..||.|.      |...:
  Rat   307 ----------------------------RQLLQRESSVGYRVPG-SASGPSLPP------LPSLQ 336

  Fly  1245 EETTATPNESSSQSLLQFSGDVPARSRAGLLLPNLSGQVPPVAMTKSMTAAEDDGGDTTPTAEGQ 1309
            |....:|:.|                                         |::|...:||...:
  Rat   337 EVDCCSPSSS-----------------------------------------EEEGSSGSPTTSPR 360

  Fly  1310 ANGASRSKQGSPFYAEPADAL-------RQAGLTSAATAILRRQHRSQMLHASQRHSEPLKAGFG 1367
               .||.:...|.....:.|.       ||.|  .|||.::..::
  Rat   361 ---LSRPRHRRPLLRSMSSAFCSLLAPERQVG--RAATMLMHNRY-------------------- 400

  Fly  1368 GSGNGAMLQPSDLEKLAGSLDELKPKPKVSQQQQQSQQQQQPTKRARNRIDHWQLDSSWEFMAKQ 1432
             :..|.::|            :|..:.:|..:.::.|..:|...|||             .|...
  Rat   401 -TAVGQLVQ------------DLLTQVRVGPESRELQGIRQALSRAR-------------AMLSA 439

  Fly  1433 DTGSHAGGDYDTAAIDWQEKENSLGRDSRADGQGKKRTLTIHQIIANRLPDLNLPELVRCSTPPQ 1497
            :.|                                                   ||.:   .||:
  Rat   440 ELG---------------------------------------------------PEKL---LPPE 450

  Fly  1498 TAALQPHVLGQDKAGVGCDGSQKSFQSQIGCRLSSYDNVFCQNSFGGIDSAQSDDGTIFSEPWDS 1562
            ...|
  Rat   451 RLEL------------------------------------------------------------- 454

  Fly  1563 SQWDTFLPHDDATINSDTIHLSKCRPALSEDDTIVEELQSTKDGSNGSCNQDTLKANRNGAGHHK 1627
                         :...::|.|..:|.
  Rat   455 -------------VLEKSLHRSVLKPL-------------------------------------- 468

  Fly  1628 LNNGNGNGKANNRPKVATILRNPSMRDREVLCHPRNKMSIQSSGPGDSLRAYTLQLAQDPSSTFA 1692
                        ||.:|..||.                                :|:.|.|  ..
  Rat   469 ------------RPILAARLRR--------------------------------RLSTDGS--LG 487

  Fly  1693 RNIENFICCTKESREAAPQVVMRNMRQFMSGMKNYLVKHGEGKFHAELETARARLKSDEFLNLDA 1757
            |..|.|       |.|..|                    |.|.|.:.             |||.:
  Rat   488 RLAEGF-------RLARTQ--------------------GPGAFGSH-------------LNLSS 512

  Fly  1758 MLETVMHQLVVLPLREHLYGIFVDHYQRSEDIQLLAQNVRYACEREAADFGIRPTVTPPSQAALR 1822
            .:|       :.|:|:.|             :|||.   .|:                ||
  Rat   513 PVE-------IEPVRQKL-------------LQLLR---AYS----------------PS----- 533

  Fly  1823 LIANLLWRLQEAELPLDKLELFLCVISTVFDATGCPRGQQLGADDFLPVLVYVVAKCGFVGAEIE 1887
              |.:.|.||..:|              ::.|.....|:..|||:|||:|..|:|:|......:|
  Rat   534 --AQIKWLLQACKL--------------LYTALKTQAGENAGADEFLPLLSLVLAQCDLPDLLLE 582

  Fly  1888 AEFMWGLLQPTLLNGEPGYYLTALCSAVQVLK------TFMASEGESGSGSLD-WRSSCLPACSS 1945
            ||:|..||:||||.||.|||||:|.:::.:|.      ....|..:....||. |....|||..:
  Rat   583 AEYMSELLEPTLLTGEGGYYLTSLSASLALLSGLSQAHALPLSPAQELQRSLALWEQRRLPATHN 647

  Fly  1946 ---VLRVIIPDECNGSLQTRTLPVRPHTTTREVCRIIAHKARITNPQDYALFKLVD-GEETLLTD 2006
               :|||...|...| ..::||.|.|.::...:.::.|.|.|:|.|..:.||...| |...|
  Rat   648 FQHLLRVAYQDPSTG-CTSKTLAVPPGSSIATLSQLCATKFRVTQPDAFGLFLYKDQGYHRL--- 708

  Fly  2007 AECPQDA---RLAAKGKHCMLAYKRIDAKIAWPTAQLA 2041
               |.:|   ||...|   .|.|:|.:.    |..|.|
  Rat   709 ---PPEALVHRLPTTG---YLIYRRAER----PETQRA 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spri	NP_001259418.1	SH2	716..813	CDD:472789	34/97 (35%)
		VPS9	1824..1922	CDD:460489	36/103 (35%)
		RA_Rin	1946..2030	CDD:340474	27/87 (31%)
Rin1	NP_620607.2	SH2_RIN1	81..181	CDD:198256	35/99 (35%)
		VPS9	513..631	CDD:128469	47/177 (27%)
		Ubl1_cv_Nsp3_N-like	649..729	CDD:475130	27/89 (30%)