Protein Alignment spri and rin1b

DIOPT Version :10

• Sequence 1: NP_001259418.1
• Gene: spri / 31987
• FlyBaseID: FBgn0085443
• Length: 2043
• Species: Drosophila melanogaster
• Sequence 2: XP_073764117.1
• Gene: rin1b / 101882011
• ZFINID: ZDB-GENE-121001-4
• Length: 747
• Species: Danio rerio
• Alignment Length: 1384
• Identity: 229/1384 - (16%)
• Similarity: 348/1384 - (25%)
• Gaps: 739/1384 - (53%)

  Fly   703 RDSSDNSPPCDLGLMERLLVTHPMWFLPGIQRSGAVHLLQGKEEGTFIVRGSSQPNTMAVSVRLP 767
            |...|.|....|.:::|||:||.:|....|....|..:||.:..|||:|...|..:...:.||:
Zfish    23 RSMMDASLQRSLSVLDRLLLTHSIWLQLSINPDSAHQILQREIVGTFLVCKCSASHRKVLCVRV- 86

  Fly   768 QDTGPYIEHYLIQSHDNVLSLESSRFTFGSIPSLIAHYAQCCDELPVQLMLPRVLREANNRKKLS 832
            |:.|  :..|.::..|:..|||||..:|..:..|:|.|....|.||..|.||..:.:|....:|.
Zfish    87 QEGG--VSQYPVREEDSTFSLESSALSFPDLCRLVAFYTISRDVLPFPLELPEAIIQAVTHTQLE 149

  Fly   833 SLALLGQEFWSYVSSPALLGPLTPSVAPSKDQQLLDAKSPLSLTETSGLGTATFFSDTVSKPPPT 897
            |::.||.||||..:||.|                                             |.
Zfish   150 SISHLGLEFWSSQTSPGL---------------------------------------------PN 169

  Fly   898 GAPPLPGGGLFSPTGSGQLLGFFSQAGTPSDTTNSSLSSFTTSGGQHMQLLSPNSVDSVILTMSP 962
            |.||                        ||....:|            :|:||..|
Zfish   170 GPPP------------------------PSAPHRTS------------RLISPCFV--------- 189

  Fly   963 VDNPGHYLPGSTGAPMAPLCPSVVDQQLSTFKVAQTAPEVDQVRPQRPKPPNTLNLKPPAPPLRW 1027
                                                               |.|.|:||.|
Zfish   190 ---------------------------------------------------NPLFLQPPQP---- 199

  Fly  1028 SKPHSPDQNGSANGNFTVTTTVTFSMENGGGGGSGPTVGNGNGKFVEVTTPAASNPFNALLNGQA 1092
                                                                             
Zfish   200 ----------------------------------------------------------------- 199

  Fly  1093 STFQTFAKRLSPEGECKDTLSSQGSSSNDSRWPPPARKLLTSPMTPLTPSGGSS------SSGGK 1151
                                 |:.:|....|:....| :..|..|.|:.|||.|      :.|..
Zfish   200 ---------------------SRTASHKRHRFKRSLR-IRVSNETSLSLSGGESELNPGETHGQN 242

  Fly  1152 SRKSRAGKESQHYKESDILESPPMQYCASALSDKISDYEDVWSHDPSDRASLLTSFRPALDTVGG 1216
            |.:.|.|..|
Zfish   243 SERRRTGGLS------------------------------------------------------- 252

  Fly  1217 VMNRRPDLLAETPSTPTPTQQSHLTPCEEETTATPNESSSQSLLQFSGDVPARSRAGLLLPNLSG 1281
            |:.|.|.|        |||.:               |...|.|                     |
Zfish   253 VLRRTPAL--------TPTSE---------------EEDEQML---------------------G 273

  Fly  1282 QVPPVAMTKSMTAAEDDGGDTTPTAEGQANGASRSKQGSPFYAEPADALRQAGLTSAATAILRRQ 1346
            |:||
Zfish   274 QIPP------------------------------------------------------------- 277

  Fly  1347 HRSQMLHASQRHSEPLKAGFGGSGNGAMLQPSDLEKLAGSLDELKPKPKVSQQQQQSQQQQQPTK 1411
                                                 :.||.:|...|:
Zfish   278 -------------------------------------SNSLPQLNKDPE---------------- 289

  Fly  1412 RARNRIDHWQLDSSWEFMAKQDTGSHAGGDYDTAAIDWQEKENSLGRDSRADGQ---GKKRTLTI 1473
                                                               ||:   ..:||
Zfish   290 ---------------------------------------------------DGEVCLALERT--- 300

  Fly  1474 HQIIANRLPDLNLPELVRCSTPPQTAALQPHVLGQDKAGVGCDGSQKSFQSQIGCRLSSYDNVFC 1538
                  |.|.|
Zfish   301 ------RAPSL------------------------------------------------------ 305

  Fly  1539 QNSFGGIDSAQSDDGTIFSEPWDSSQWDTFLPHDDATINSDTIHLSKCRPALSEDDTIVEELQST 1603
                     |:.|..:.||                               :|.|:||.|:
Zfish   306 ---------AELDSNSSFS-------------------------------SLEEEDTQVD----- 325

  Fly  1604 KDGSNGSCNQDTLKANRNGAGHHKLNNGNGNGKANNRPKVATILRNPSMRDREVLCHPRNKMSIQ 1668
                                            .|:..|..|...|.|
Zfish   326 --------------------------------LAHQWPPAARGTRFP------------------ 340

  Fly  1669 SSGPGDSLRAYTL-----------------QLAQDPSSTFARNIENFICCTKESREAAPQ----V 1712
            |:.|..:||..|.                 :|::|..|||...:::|:...::..||:..    .
Zfish   341 SANPTSTLRRMTAAFVCVFAPERRVARLVDELSRDRRSTFGSLVQDFLEKKRQEMEASVHSSAVE 405

  Fly  1713 VMRNMRQFMSGMKNYLVKHGEGKFHAELETARARLKSDEFLNLDAMLETVMHQLVVLPLREHLYG 1777
            :::.||:|::..|:.|::.||  ....:||.   :..:|   .|..||..:...|:.||:..|..
Zfish   406 MLQGMRRFLTQAKSLLLEAGE--IEPPIETL---VPENE---KDLALEKALFGCVLKPLKVQLQQ 462

  Fly  1778 IFVDHYQRSEDIQLLAQNV----RYACEREAADFGIRPTVTPPSQAALRLIANLLWRLQEAELPL 1838
            ..|..:.|...:|.:.:::    ..|.||.|...|:. .|....:|..:|:.     :|.:..|:
Zfish   463 TLVSLHTRDGSLQRVTESLLAHQEGALERLAVRVGVL-DVRGVERAKAKLML-----MQRSHSPI 521

  Fly  1839 DKLELFLCVISTVFDATGCPRGQQLGADDFLPVLVYVVAKCGFVGAEIEAEFMWGLLQPTLLNGE 1903
            ||:.|.|.|..:|:.|.|...||.:|:|||||.|.||:.:|......:|.|:|..||:|:.|.||
Zfish   522 DKVLLLLQVCKSVYKAMGTQPGQDVGSDDFLPALSYVLIQCNIPQLLLETEYMMELLEPSWLTGE 586

  Fly  1904 PGYYLT----ALC----------------SAVQVLKTFMASEGESGSGSLDWRSSCLPACSSVLR 1948
            .|||||    :||                .|.:.|:.:....|:......|.:..     ...:|
Zfish   587 GGYYLTSVYASLCLIQSKPGTTPTSGLTNEAQEYLREWSRRRGQEAKTHKDTQLK-----QRFVR 646

  Fly  1949 VIIPDECNGSLQTRTLPVRPHTTTREVCRIIAHKARITNPQDYALFKLVDGEETLLTDAECPQDA 2013
            ::..||....:  |||..:.......:.:..|....::.||.|.||...:||...|     |...
Zfish   647 ILFQDEIRSGV--RTLLWKAGENVDALAQSCAALFGVSEPQHYCLFWRNEGEMRPL-----PAHV 704

  Fly  2014 RLAAKGKH--CMLAYKRID 2030
            :....|.|  ..|:|.|.|
Zfish   705 QPHQLGTHEGASLSYLRSD 723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spri	NP_001259418.1	SH2	716..813	CDD:472789	31/96 (32%)
		VPS9	1824..1922	CDD:460489	40/117 (34%)
		RA_Rin	1946..2030	CDD:340474	21/85 (25%)
rin1b	XP_073764117.1	None