Protein Alignment spri and rin1

DIOPT Version :10

• Sequence 1: NP_001259418.1
• Gene: spri / 31987
• FlyBaseID: FBgn0085443
• Length: 2043
• Species: Drosophila melanogaster
• Sequence 2: XP_031756551.1
• Gene: rin1 / 100495483
• XenbaseID: XB-GENE-493062
• Length: 886
• Species: Xenopus tropicalis
• Alignment Length: 1439
• Identity: 261/1439 - (18%)
• Similarity: 421/1439 - (29%)
• Gaps: 641/1439 - (44%)

  Fly   638 HGGAFEDDMQALLPKCSRRSRDELSQSRT-------SLVSSSEGGILAEGETSSED--DEE---- 689
            |||.         .|..:.:.|.|||:..       |.:..::..:|....:|..:  ::|
 Frog    26 HGGG---------KKSKKENLDSLSQAGARQDHTGWSKIRQTQWNLLGHSLSSGTEGANQEKYSL 81

  Fly   690 -----------EPVEAEDEGEESSRDSSDNSPPCDLGLMERLLVTHPMWFLPGIQRSGAVHLLQG 743
                       ||| .:...:|||........|..:.:.:|||:|..:|....:..:.|:|:||.
 Frog    82 CRVGPSCTRMTEPV-YDFPYQESSPTPIRKGSPTSVSITDRLLLTQSVWLHRTVNSATALHILQR 145

  Fly   744 KEEGTFIVRGSSQPNTMAVSVRLPQDTGPYIEH--YLIQSHDNVLSLESSRFTFGSIPSLIAHYA 806
            :..|||:||.|:....|.:.|||..|:||...|  |:.:|...:. ||.|..||..:..|:|||:
 Frog   146 EPPGTFLVRKSNTRQKMVLCVRLSDDSGPSFIHQAYIHKSPAGIY-LEESELTFPDLIRLVAHYS 209

  Fly   807 QCCDELPVQLMLPRVLREANNRKKLSSLALLGQEFWSYVSSPALLGPLTPSVAPSKDQQLLDAKS 871
            ...|.||..|.||..:.:..:||:|.:::.||.|||.  |:.....||.||.:||
 Frog   210 SEKDVLPYTLRLPAAIEKVPSRKQLEAISHLGLEFWR--SALNARDPLLPSASPS---------- 262

  Fly   872 PLSLTETSGLGTATFFSDTVSKPPPTGAPPLPGGGLFSPTGSGQLLGFFSQAGTPSDTTNSSLSS 936
                                    |:.:||||
 Frog   263 ------------------------PSPSPPLP--------------------------------- 270

  Fly   937 FTTSGGQHMQLLSPNSVDSVILTMSPVDNPGHYLPGSTGAPMAPLCPSVVDQQLSTFKVAQTAPE 1001
                      |||||          |.:.|....|.        |.||:
 Frog   271 ----------LLSPN----------PSEIPDIITPS--------LIPSL---------------- 291

  Fly  1002 VDQVRPQRPKPPNTLNLKPPAPPLRWSKPHSPDQNGSANGNFTVTTTVTFSMENGGGGGSGPTVG 1066
                                       |..||                   :|...|||.|
 Frog   292 ---------------------------KTRSP-------------------LEVSSGGGEG---- 306

  Fly  1067 NGNGKFVEVTTPAASNPFNALLNGQASTFQTFAKRLSPEGECKDTLSSQGSSSNDSRWPPPARKL 1131
                         |...||.|...:.|   ...||...:...|..:|::.|.|
 Frog   307 -------------ALCFFNPLFKPKVS---GALKRSQFQRSIKVRVSTENSGS------------ 343

  Fly  1132 LTSPMTPLTPSGGSSSSGGKSRKSRAGKESQHYKESDILESPPMQYCASALSDKISDYEDVWSHD 1196
            |:.|:.|                                  ||
 Frog   344 LSPPINP----------------------------------PP---------------------- 352

  Fly  1197 PSDRASLLTSFRPALDTVGGVMNRRPDLLAETPSTPTPTQQSHLTPCEEETTATPNESSSQSLLQ 1261
                                               |.|:|:  :...|||....|
 Frog   353 -----------------------------------PVPSQE--VVKEEEEERIAP---------- 370

  Fly  1262 FSGDVPARSRAGLLLPNLSGQVPPVAMTKSMTAAEDDGGDTTPTAEGQANGASRSKQGSPFYAEP 1326
                         ||.:...:|....::....                             |.:|
 Frog   371 -------------LLASQEAEVEQCQLSSDQN-----------------------------YRKP 393

  Fly  1327 ADALRQAGLTSAATAILRRQHRSQMLHASQRHSEPLKAGFGGSGNGAMLQPSDLEKLAGSLDELK 1391
            ..:||                        ||..:.|..|                       .::
 Frog   394 RSSLR------------------------QRLKKSLSKG-----------------------SME 411

  Fly  1392 PKPKVSQQQQQSQQQQQPTKRARNRIDHWQLDSSWEFMAKQDTGSHAGGDYDTAAIDWQEKENSL 1456
            ...|:||.:                                   |..||||
 Frog   412 LGLKISQLR-----------------------------------STDGGDY-------------- 427

  Fly  1457 GRDSRADGQGKKRTLTIHQIIANRLPDLNLPELVRCSTPPQTAALQPHVLGQDKAGVGCDGSQKS 1521
                                                                 |..|....:|:|
 Frog   428 -----------------------------------------------------KVPVPLTRTQES 439

  Fly  1522 FQSQIGCRLSSYDNVFCQNSFGGIDSAQ-SDDGTIFSEPWDSSQWDTFLPHDDATINSDTIHLSK 1585
            .:.:             |:|..|:...: .|.|:..||...|..:..|.|
 Frog   440 KEIE-------------QSSSNGLSPVEVQDSGSSSSEEGTSEDFGKFSP--------------- 476

  Fly  1586 CRPALSEDDTIVEELQSTKDGSNGSCNQDTLKANRNGAGHHKLNNGNGNGKANNRPKVATILRNP 1650
                           |.|:                    ..|:...:|.............|.:|
 Frog   477 ---------------QLTR--------------------RRKIKKKSGRSSFRAVSGAFLSLLSP 506

  Fly  1651 SMRDREVLCHPRNKMSIQSSGPGDSLRAYTLQLAQDPSSTFARNIENFICCT------------K 1703
               :|:||      |.|:             ::::|..:.|.:.:::|:...            .
 Frog   507 ---ERKVL------MFIE-------------EMSRDIQTEFGKELQDFLRRVTDGESMGGKEKDT 549

  Fly  1704 ESREAAPQVVMRNMRQFMSGMKNYLVKHGEGKFHAELETARARLKSDEFLNLDAMLETVMHQLVV 1768
            |..|.:.:.:::.:|.||..:|           |...|:|..:|::......|.:||..:|:|::
 Frog   550 EDEEGSYKTLLKEVRDFMDKVK-----------HVLRESAELQLETLSLEEQDRVLEKSLHRLIL 603

  Fly  1769 LPLREHLYGIFVDHYQRSEDIQLLAQNVRYACEREAADFGIRPTVTPPSQAALRLIANLLWRLQE 1833
            .||..||..:.....:.|.|::.|.:|::......::..|:  ::..|:...|..|.:.|.|:||
 Frog   604 KPLNAHLVSVIHKGVEESGDLERLGKNMQAVKNSGSSLLGV--SLMAPTAPELEKIRHKLLRMQE 666

  Fly  1834 AELPLDKLELFLCVISTVFDATGCPRGQQLGADDFLPVLVYVVAKCGFVGAEIEAEFMWGLLQPT 1898
            ...|.||:.|.|.....|:......:....|||:|||.|.||:|.|......|...:...||...
 Frog   667 KYSPTDKVRLLLQACRLVYRNIDAQQDDACGADEFLPALCYVLALCDLPQLLIHTYYTGELLPQD 731

  Fly  1899 LLNGEPGYYLTALCSAVQVLKTFMASEGESGSGSLDW--RSSCLPACSSV---LRVIIPDECNGS 1958
            .|.||.|||||::.:::.||.:......:.|....:|  :...||:.:.:   |||...|..||
 Frog   732 TLVGEGGYYLTSVSASLSVLSSLHTHPPDMGLSLSEWHRKRQGLPSLNDLQNFLRVAHQDPVNG- 795

  Fly  1959 LQTRTLPVRPHTTTREVCRIIAHKARITNPQDYALFKLVDGEETLLTDAECPQD--ARLAAKGKH 2021
            ..|:|:.:||..|..::..:.|.|.:.:||:|||:|....|.:.||.....||.  |:|..:|.:
 Frog   796 CTTKTILLRPSQTVVDLTHLCALKFKPSNPEDYAIFLYCGGNQQLLLPDSQPQQIKAQLKERGSN 860

  Fly  2022 CMLAYKRID 2030
            ....|:.::
 Frog   861 FYFCYQCLE 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spri	NP_001259418.1	SH2	716..813	CDD:472789	35/98 (36%)
		VPS9	1824..1922	CDD:460489	35/97 (36%)
		RA_Rin	1946..2030	CDD:340474	28/88 (32%)
rin1	XP_031756551.1	SH2_RIN1	118..218	CDD:198256	37/100 (37%)
		VPS9	654..742	CDD:460489	32/87 (37%)
		RA_Rin1	782..869	CDD:340735	28/87 (32%)