Protein Alignment spri and rin2

DIOPT Version :9

• Sequence 1: NP_001259418.1
• Gene: spri / 31987
• FlyBaseID: FBgn0085443
• Length: 2043
• Species: Drosophila melanogaster
• Sequence 2: XP_012818164.1
• Gene: rin2 / 100144744
• XenbaseID: XB-GENE-484799
• Length: 881
• Species: Xenopus tropicalis
• Alignment Length: 1396
• Identity: 274/1396 - (19%)
• Similarity: 412/1396 - (29%)
• Gaps: 597/1396 - (42%)

  Fly   658 RDELSQSRTSLVSSSEGGILAEGETSSEDDEEEPVEAEDEGEESSRDSSDNSPPCDLGLMERLLV 722
            |||.|..|           |:..|..|....|     :.|.:...|||...|....|.::::||.
 Frog    40 RDEESTDR-----------LSRKEMESNHSPE-----KKEVKSFLRDSGYESVSFKLSILDKLLH 88

  Fly   723 THPMWFLPGIQRSGAVHLLQGKEEGTFIVRGSSQPNTMAVSVRLPQDTGPYIEHYLIQSHDNVLS 787
            |||:|...|:.......:|..:...||:||.|::.....:|||:|.....:.:.::|:......|
 Frog    89 THPVWLQLGLSDDKVPGILLEQPPATFLVRKSNKLQKKVISVRMPNQFASHFQEFVIKESSYTFS 153

  Fly   788 LESSRFTFGSIPSLIAHYAQCCDELPVQLMLPRVLREANNRKKLSSLALLGQEFWSYVSSPALLG 852
            ||.|..:|..|..|||.|....|.||..|.||..:..|....:|..:|.||.|||   ||||...
 Frog   154 LEGSGISFADIFRLIAFYCISRDVLPFTLKLPHAIATAKTEAELEEIAQLGTEFW---SSPANCK 215

  Fly   853 PLTPSVAPSKDQQLLDAKSPLSLTETSGLGTATFFSDTVSKPPPTGAPPLPGGGLFSPTGSGQLL 917
            |..|...                                       |.||
 Frog   216 PRYPHAV---------------------------------------AWPL--------------- 226

  Fly   918 GFFSQAGTPSDTTNSSLSSFTTSGGQHMQLLSPNSVDSVILTMSPVDNPGHYLPGSTGAPMAPLC 982
                    |||..|.          :..||...|.|.| :.|.:|
 Frog   227 --------PSDCLNK----------ESPQLPRLNGVHS-LRTRTP-------------------- 252

  Fly   983 PSVVDQQLSTFKVAQTAPEVDQVRPQRPKPPNTLNLKPPAPPLRWSKPHSPDQNGSANGNFTVTT 1047
                    |..:.:||...:..:.|                  .:.|.||
 Frog   253 --------SELECSQTKGALCFINP------------------LFLKVHS--------------- 276

  Fly  1048 TVTFSMENGGGGGSGPTVGNGNGKFVEVTTPAASNPFNALLNGQASTFQTFAKRLSPEGECKDTL 1112
                  |:.|||.                                       ||.|.  ..::|.
 Frog   277 ------EDAGGGW---------------------------------------KREST--RTQETN 294

  Fly  1113 SSQGSSSNDSRWPPPARKLLTSPMTPLTPSGGSSSSGGKSRKSRAGKESQHYKESDILESPPMQY 1177
            .::...|...|.|||.   :||..|.|             :.|||.|:     ||.:.|
 Frog   295 GTERVKSAPPRPPPPC---ITSHRTNL-------------QLSRAVKQ-----ESSMPE------ 332

  Fly  1178 CASALSDKISDYEDVWSHDPSDRASLLTSFRPALDTVGGVMNRRPDLLAETPSTPTPTQQSHLTP 1242
                                       |.|.          ||...  ||.|:
 Frog   333 ---------------------------TVFH----------NREGK--AEAPN------------ 346

  Fly  1243 CEEETTATPNESSSQSLLQFSGDVPARSRAGLLLPNLSGQVPPVAMTKSMTAAEDDGGDTTPTAE 1307
                ..|||                               :||..:.|..|.:...|.|::
 Frog   347 ----NKATP-------------------------------IPPPRLKKQATISRWQGNDSS---- 372

  Fly  1308 GQANGASRSKQGSPFYAEPADALRQAGLTSAATAILRRQHRSQMLHASQRHSEPLKAGFGGSGNG 1372
                        |||                          |....:|...|:|
 Frog   373 ------------SPF--------------------------SGSYCSSSVESQP----------- 388

  Fly  1373 AMLQPSDLEKLAGSLDELKPKPKVSQQQQQSQQQQQPTKRARNRIDHWQLDSSWEFMAKQDTGSH 1437
                            |..|..|..|...::|....|.:..
 Frog   389 ----------------EESPPQKTIQSLTRAQNSDSPARTT------------------------ 413

  Fly  1438 AGGDYDTAAIDWQEKENSLGRDSRADGQGKKRTLTIHQIIANRLPDLNLPELVRCSTPPQTAALQ 1502
                                                  ::..||.|:::      ||
 Frog   414 --------------------------------------LLTQRLSDMSI------ST-------- 426

  Fly  1503 PHVLGQDKAGVGCDGSQKSFQSQIGCRLSSYD---NVFCQNSFGGIDSAQSDDGTIFSEPWDSSQ 1564
                          .|..||:         ||   .|||:.                    ||
 Frog   427 --------------SSSDSFE---------YDRPGQVFCEG--------------------DS-- 446

  Fly  1565 WDTFLPHDDATINSDTIHLSKCRPALSEDDTIVEELQSTKDGSNGSCNQDTLKANRNGAGHHKLN 1629
                              |..|            |.:|.::|.:....  :.|......|..|:
 Frog   447 ------------------LEDC------------EEESDQEGMSPPIK--SRKKRGTSLGFSKI- 478

  Fly  1630 NGNGNGKANNRPKVATILRNPSMRDREVLCHPRNKMSIQSSGPGDSLRAYTLQLAQDPSSTFARN 1694
                         |.|.||..|.....::. |..||..:.:......|.|...|.||..|....|
 Frog   479 -------------VKTHLRKVSGVFSSLIT-PEKKMVKKIATMSRDKRTYFGCLVQDYISFLQEN 529

  Fly  1695 IENFICCTKESREAAPQVVMRNMRQFMSGMKNYLVKHGEGKFHAELETARARLKSDEFLNLDAML 1759
            .|..:..|.         ::..:||||:.:||||.:      .:||:.....|..::  .:|.:|
 Frog   530 KECHVSSTD---------MLHTIRQFMTQVKNYLAQ------SSELDPPIESLIPED--QIDVVL 577

  Fly  1760 ETVMHQLVVLPLREHLYGIFVDHYQRSEDIQLLAQNVRYACEREAADFGIRPTVTPPSQAALRLI 1824
            |..||:.::.||:.|:..:..:........:.|.:|::...:|...:.|:. |.||.|....::.
 Frog   578 EKAMHKCILKPLKSHIESMLKEFRVADGSWRQLKENLQLVRQRSPQELGVL-TPTPESMDIEKMR 641

  Fly  1825 ANLLWRLQEAELPLDKLELFLCVISTVFDATGCPRGQQLGADDFLPVLVYVVAKCGFVGAEIEAE 1889
            ...| .:|:...|..|:.|.|.|...::.......|:..|||||||||.||:|:|..:..:.|.|
 Frog   642 IKFL-NMQKMYSPERKVMLLLRVCKLIYTCMENNSGRMYGADDFLPVLTYVIAQCDMLEIDTEIE 705

  Fly  1890 FMWGLLQPTLLNGEPGYYLTALCSAVQVLKTFMASE------GESGSGSLDWR-----SSCLPAC 1943
            :|..||.|.||:||.|||||:...|:.::|.|...:      .|:......|.     :..:|:.
 Frog   706 YMMELLDPALLHGEGGYYLTSAYGALSLIKNFQEEQAARLLNSETRDTLKQWHKRRTTNRSIPSI 770

  Fly  1944 ---SSVLRVIIPDE---CNGSLQTRTLPVRPHTTTREVCRIIAHKARITNPQDYALFKLVDGEET 2002
               .:.|||.:.:.   |.|    :||.|:|:|||.:||.:.|.:..|.:|::|.||..:|....
 Frog   771 DDFQNYLRVALQEADSGCTG----KTLIVKPYTTTEDVCHMCAKRFGIQDPENYGLFLYIDDTWQ 831

  Fly  2003 LLTDAECPQDARLAAKGKHCM----LAYKRI 2029
            .|::...||..:.....:..:    ..||||
 Frog   832 QLSEDTYPQKIKAELHSRPQLQVFHFVYKRI 862

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spri	NP_001259418.1	SH2	716..813	CDD:301589	29/96 (30%)
		VPS9	1821..1922	CDD:280383	38/100 (38%)
		UBQ	1946..2026	CDD:294102	24/86 (28%)
rin2	XP_012818164.1	SH2_RIN2	82..181	CDD:198257	31/98 (32%)
		VPS9	636..752	CDD:128469	40/116 (34%)
		RA_Rin2	773..863	CDD:340548	28/94 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I8786
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	233	1.000	Inparanoid score	I3334
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001291
OrthoInspector	1	1.000	-	-		otm49188
Panther	1	1.100	-	-	O	PTHR23101
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3144
SonicParanoid	1	1.000	-	-		X2330
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.090