Protein Alignment spri and rin3

DIOPT Version :10

• Sequence 1: NP_001259418.1
• Gene: spri / 31987
• FlyBaseID: FBgn0085443
• Length: 2043
• Species: Drosophila melanogaster
• Sequence 2: XP_002933252.2
• Gene: rin3 / 100038102
• XenbaseID: XB-GENE-488895
• Length: 1035
• Species: Xenopus tropicalis
• Alignment Length: 1383
• Identity: 271/1383 - (19%)
• Similarity: 458/1383 - (33%)
• Gaps: 429/1383 - (31%)

  Fly   670 SSSEGGILAEGETSSEDDEEEPVEAEDEGEESSRDSSDNSPPCDLGLMERLLVTHPMWFLPGIQR 734
            |.:..|:.|....|...|..:|   |..|.|     ::...|..:.:::||:.|.|:|....:..
 Frog     4 SGTSAGMEAAARDSCPADVGDP---EKHGTE-----NNCHVPSGISVLDRLIKTCPVWLQLCMNP 60

  Fly   735 SGAVHLLQGKEEGTFIVRGSSQPNTMAVSVRLPQDTGPY-IEHYLIQSHDNVLSLESSRFTFGSI 798
            ..||.:|:.:..|.|::....:...|.:.|.:..:.... :..|.|:....::.||||...|..|
 Frog    61 EQAVDILKKEGPGVFLITRDVERKCMVLWVHVTSNKEQADVLRYNIKEEKTMMYLESSVLVFEDI 125

  Fly   799 PSLIAHYAQCCDELPVQLMLPRVLREANNRKKLSSLALLGQEFWSYVSSPALLGPLTPSVAPSKD 863
            ..|:|.|....|.||..|.||:.:..|...|:|.:.:.||..||.
 Frog   126 FKLVAFYCVSRDVLPFPLKLPQAIAAAQTYKELETFSNLGTGFWD-------------------- 170

  Fly   864 QQLLDAKSPLSLTETSGLGTATFFSDTVSKPPPTGAPPLPGGGLFSPTGSGQLLGFFSQAGTPSD 928
                     .:.|:.:.|..|.....|                   ..|..|.....|.....::
 Frog   171 ---------SAFTDGNKLAAAKQHRCT-------------------SNGDFQTCSVRSSHHIQNE 207

  Fly   929 TTNSSLSSFTTSGGQHMQLLSPNSVDSVILTMSPVDNPGHYLPGSTGAPMAPLCPSVVDQQLSTF 993
            ..|.:.....:.|...:..:||..::.....::              |...||...|.:.::.|.
 Frog   208 ANNCTCEIEISVGSGRLWFVSPIFIEECSNVLA--------------AEKLPLLNCVANSEIKTH 258

  Fly   994 KVAQTAPEVDQVRPQRPKPPNTLNLKPPAPPLRWSKPHSPDQNGSANGNFTVTTTVTFSMENGGG 1058
            |:..          :||.||      ||.||
 Frog   259 KIVY----------RRPPPP------PPPPP---------------------------------- 273

  Fly  1059 GGSGPTVGNGNGKFVEVTTPAASNPFNALLNGQASTFQTFAKRLSPEGECKDTLSSQGSSSNDSR 1123
                               ||..||
 Frog   274 -------------------PALKNP---------------------------------------- 279

  Fly  1124 WPPPARKLLTSPMTPLTPSGGSSSSGGKSRKSRAGKESQHYKESDILESPPMQYCASALSDKISD 1188
                       |:..:.|||...:.          |.|..|........||....|..||..:..
 Frog   280 -----------PLPSVPPSGPPPNY----------KRSHSYTSPQKSPRPPSFSVAPPLSCLLHS 323

  Fly  1189 YEDVWSHDPSDRASLLTSFRPALDTVGGVMNRRPDLLAETPSTPTPTQQSHLTPCEEETTATPNE 1253
            .    |:.|...:..|||..|.:.       :.|      ||:.||....  ||        |..
 Frog   324 S----SNQPMTPSLSLTSHAPCVP-------QNP------PSSNTPIVSQ--TP--------PLS 361

  Fly  1254 SSSQSLLQFSGDVPARSRAGLLLPNLSGQVPPVAMT---KSMTAAED--DGGDTTPTAEGQANGA 1313
            ..||:|.|.. |:|..|      .::..:|.|:|.:   ..:.:.||  |..:....:.|:.|
 Frog   362 QMSQNLSQLK-DLPNTS------TDICVEVQPLAQSCEEMKINSTEDKKDSVEYAICSSGEQN-- 417

  Fly  1314 SRSKQGSPFYAEPADALRQAGLTSAATAILRRQHRSQMLHASQRHSEPLKAGFGGSGNGAMLQPS 1378
                              |....||.....|||        |.:.||       ..||
 Frog   418 ------------------QKSAMSAPVVPKRRQ--------SGKISE-------NKGN------- 442

  Fly  1379 DLEKLAGSLDELKPKPKVSQQQQQSQQQQQPTKR--ARNRIDHWQLDSSWEFMAKQDTGSHAGGD 1441
                      .::.|..:.|.::||.|..:...:  |...::|..:     .:.|:|
 Frog   443 ----------SVRKKELLQQTERQSTQSVKSVSKDQAETHLNHETI-----MLIKKD-------- 484

  Fly  1442 YDTAAIDWQEKE-NSLGRDSRADGQGKKRTLTIHQIIANRLPDLNLPELVRCSTPPQTAALQPHV 1505
                 |:..|:: .|.|:.::.......||......:|..||..|....|:        .|:...
 Frog   485 -----IETLEQQCISQGKRNKTPPVPPPRTKKFSHRVAPALPGQNSHSPVK--------ELRSRT 536

  Fly  1506 LGQDKAGVGCDGSQKSFQSQIGCRLSSYDNVFCQNSFGGIDSAQSDDGTIFSEPWDSSQWDTFLP 1570
            ...|......|..|....||..|  |.|.: |.:|                .||.      |.||
 Frog   537 QSSDYKAKCSDVKQNGRTSQSDC--SKYKD-FAKN----------------KEPC------TRLP 576

  Fly  1571 HD-----DATINSDTIHLSKCRPALS-EDDTIVEELQSTKDGSNGSCNQDTLKANRNGAGHHKLN 1629
            ..     |.:::|....|:  .|..| |.|::          |..|..:|        ..|.|::
 Frog   577 TKELKSLDTSLSSPASGLT--IPVTSPEQDSL----------STSSAEED--------HDHEKVS 621

  Fly  1630 NGNGNGKANNRPKVATILRNPSMRDRE--VLCHPRNKMSIQS--------SGPGDSLRAYTLQLA 1684
                               :||:|...  :|...:|::||.:        ......|:....:||
 Frog   622 -------------------SPSIRKTHSFMLDRAKNRLSIVTITNVFSAFMSAERKLQKKITELA 667

  Fly  1685 QDPSSTFARNIENFICCTKE--SREAAPQVVMRNMRQFMSGMKNYLVKHGEGKFHAELETARARL 1747
            ||..:.|...::::...:.:  :::::...:::.:|..|:.:|:|||:..|.|...|..|    :
 Frog   668 QDKETYFGNLVQDYKAYSLDMMAKQSSSTEMLQEIRLMMTQLKSYLVQSAELKTMIESTT----V 728

  Fly  1748 KSDEFLNLDAMLETVMHQLVVLPLREHLYGIFVDHYQRSEDIQLLAQNVRYACEREAADFGIRPT 1812
            .:|:  .::|::|..:.:.|:.||:..:.|...:.:.:...::||.:|.....:....|.|:  |
 Frog   729 YTDD--RIEAIVEAALCKCVLKPLKSPIEGYLREIHTKDGSLRLLKENQIVIQDITTTDLGV--T 789

  Fly  1813 VTPPSQAALRLIANLLWRLQEAELPLDKLELFLCVISTVFD--ATGCPRGQQLGADDFLPVLVYV 1875
            .:.|..:.:..|......:.:...|..|:...|.....::|  |||.| |:..|||||||||:||
 Frog   790 TSVPEISVMEKITQKFSVMHKTYSPEKKVSYLLKACKMIYDSMATGSP-GKLHGADDFLPVLMYV 853

  Fly  1876 VAKCGFVGAEIEAEFMWGLLQPTLLNGEPGYYLTALCSAVQVLKTF--------MASEGESGSGS 1932
            :|:|.......:.|:|..|:.|.|..||..||||....|::.:|.:        ::.|.:.....
 Frog   854 LARCDLTELLQDVEYMMELMDPALQLGEGSYYLTTTYGALEHIKNYDKITVTRQLSVEVQDSIHR 918

  Fly  1933 LDWRSSCLPACSSVLRVIIPDECNGSLQ-----TRTLPVRPHTTTREVCRIIAHKARITNPQDYA 1992
            .:.|.:...|  .|.|..|.|....|.:     :|||.::|.|....:.:..|.|.::..||:|.
 Frog   919 WERRRTLNKA--RVSRSSIQDFITISFEELDSKSRTLVIKPDTNVELLLQDCAEKFQVLEPQNYG 981

  Fly  1993 LFKLVDGEETLLTDAECP 2010
            |:..|:.....|.|...|
 Frog   982 LYVQVNERSLRLADDALP 999

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spri	NP_001259418.1	SH2	716..813	CDD:472789	24/97 (25%)
		VPS9	1824..1922	CDD:460489	36/107 (34%)
		RA_Rin	1946..2030	CDD:340474	20/70 (29%)
rin3	XP_002933252.2	SH2_RIN3	42..142	CDD:198258	26/99 (26%)
		VPS9	798..901	CDD:460489	36/103 (35%)
		RA_Rin3	936..1023	CDD:340547	17/64 (27%)