Protein Alignment spri and rin2a

DIOPT Version :9

• Sequence 1: NP_001259418.1
• Gene: spri / 31987
• FlyBaseID: FBgn0085443
• Length: 2043
• Species: Drosophila melanogaster
• Sequence 2: XP_001345314.1
• Gene: rin2a / 100006622
• ZFINID: ZDB-GENE-090312-194
• Length: 938
• Species: Danio rerio
• Alignment Length: 1413
• Identity: 285/1413 - (20%)
• Similarity: 427/1413 - (30%)
• Gaps: 605/1413 - (42%)

  Fly   660 ELSQSRTSLVSSSEGGIL--AEGETSSEDDEEEPVEAEDEGEESSRDSSDNSPPCDLGLMERLLV 722
            ||.|.........|..||  .|||.|....:....    .|....|||..:|....:.:::||:.
Zfish    31 ELKQEMVQPAREPETEILQGLEGEVSGLFLQSSAC----AGVPGVRDSGYDSLRRRMSMLDRLMQ 91

  Fly   723 THPMWFLPGIQRSGAVHLLQGKEEGTFIVRGSSQPNTMAVSVRLPQDTGPYIEHYLIQSHDNVLS 787
            ||.:|.|..:....|.|:||.:..|:|:||...:.....:|:|:..|| ..:..:.::......|
Zfish    92 THSVWLLLSLSDDEARHILQPQPAGSFVVRRCYKLQKKVISLRMDSDT-LIVRDFPVKESQYTFS 155

  Fly   788 LESSRFTFGSIPSLIAHYAQCC---DELPVQLMLPRVLREANNRKKLSSLALLGQEFW------- 842
            ||.|..:|..:..|:|.   ||   |.||..|.||..:..|.....|..:|.||:.||
Zfish   156 LEGSGISFADLFRLVAF---CCISRDVLPFTLKLPEAIASAKTPTDLEEVAKLGKGFWDSELCNK 217

  Fly   843 --SYVS--------------SPALLGPLTPS-VAPSKDQQLLDAKSPLSLTETSGLGTATFFSDT 890
              |.||              |||:....||| :..|:....|...:||            |....
Zfish   218 NKSSVSGETACDGSKQRLKRSPAVPFTRTPSELECSQSNGALCFINPL------------FLQTH 270

  Fly   891 VSKPPPTGAPPLPG--GGLFSPTGSGQLLGFFSQAGTPSDTTNSSLSSFTTSGGQHMQLLSPNSV 953
            .|.|.|....|.||  ||                                  |.||
Zfish   271 QSNPSPKKQEPSPGDEGG----------------------------------GSQH--------- 292

  Fly   954 DSVILTMSPVDNPGHYLPGSTGAPMAPLCPSVVDQQ--LSTF-KVAQTAPEVDQVRPQRPKPPNT 1015
                         .|.....||           .||  .|.| :...:.|.:...|.:..:.|
Zfish   293 -------------HHRALHRTG-----------QQQGDSSVFCRKTPSKPHISVSRSESERSP-- 331

  Fly  1016 LNLKPPAPPLRWSKPHSPDQNGSANG-----NFTVTTTVTFSMENGGGGGSGPTVGNGNGKFVEV 1075
                ||.||        |.:.||:..     ..|:..||.:                       :
Zfish   332 ----PPRPP--------PPRFGSSRSAVLRKQKTMPETVCW-----------------------I 361

  Fly  1076 TTPAASNPFNALLNGQASTFQTFAKRLSPEGECKDTLSSQGSSSNDSRWPPPARKLLTSPMTPLT 1140
            .||...   .:||....|:|.:    |||            |||      ||  |..:.|:  |.
Zfish   362 KTPQEK---TSLLGRLGSSFIS----LSP------------SSS------PP--KKFSKPI--LV 397

  Fly  1141 PSGGSSSSGGKSRKSRAGKESQHYKESDILESPPMQYCASALSDKISDYEDVWSHDPSDRASLLT 1205
            ||..:.:|.|                  :|::..:: |..||.|:..:....||
Zfish   398 PSARNKNSSG------------------LLDADGIR-CHMALDDQTIEDAVSWS----------- 432

  Fly  1206 SFRPALDTVGGVMNRRPDLLAETPSTPTPTQQSHLTPCEEETTATPNE--------SSSQSLLQF 1262
                               ||:. |:..||...:.:|..|. .:|..|        :||...|.|
Zfish   433 -------------------LAKL-SSRNPTAMENGSPAHEH-CSTGRERLSDISISTSSSDSLDF 476

  Fly  1263 SGDVPARSRAGLLLPNLSGQVPPVAMTKSMTAAEDDGGDTTPTAEGQANGASRSKQGSPFYAEPA 1327
            |...|....|.   |:.:.:  |.. ..|....||||          .|..|..:..|||.::..
Zfish   477 SHSFPLPMEAS---PSKTDR--PTG-DSSQEEEEDDG----------INLESDQEVPSPFKSKKQ 525

  Fly  1328 DALRQAGLTSAATAILRRQHRSQMLHASQRHSEPLKAGFGGSGNGAMLQPSDLEKLAGSLDELKP 1392
            :        ||.|.:|.|..|.|                             |.|::..|:.|
Zfish   526 N--------SAGTFVLPRALRGQ-----------------------------LRKMSDVLNSL-- 551

  Fly  1393 KPKVSQQQQQSQQQQQPTKRARNRIDHWQLDSSWEFMAKQDTGSHAGGDYDTAAIDWQEKENSLG 1457
                          ..|.:||..:|    ::.|      :|.|::
Zfish   552 --------------MTPERRAIRKI----VEQS------RDKGTY-------------------- 572

  Fly  1458 RDSRADGQGKKRTLTIHQIIANRLPDLNLPELVRCSTPPQTAALQPHVLGQDKAGVGCDGSQKSF 1522
                                                                             
Zfish   573 ----------------------------------------------------------------- 572

  Fly  1523 QSQIGCRLSSYDNVFCQNSFGGIDSAQSDDGTIFSEPWDSSQWDTFLPHDDATINSDTIHLSKCR 1587
               .||.:..|
Zfish   573 ---FGCLVQDY------------------------------------------------------ 580

  Fly  1588 PALSEDDTIVEELQSTKDGSNGSCNQDTLKANRNGAGHHKLNNGNGNGKANNRPKVATILRNPSM 1652
                     |..||.                          |.|
Zfish   581 ---------VSFLQE--------------------------NRG--------------------- 589

  Fly  1653 RDREVLCHPRNKMSIQSSGPGDSLRAYTLQLAQDPSSTFARNIENFICCTKESREAAPQVVMRNM 1717
                  ||        :||         |:|.|                              .:
Zfish   590 ------CH--------TSG---------LELLQ------------------------------TL 601

  Fly  1718 RQFMSGMKNYLVKHGEGKFHAELETARARLKSDEFLNLDAMLETVMHQLVVLPLREHLYGIFVDH 1782
            ||||:.||:||::      .:||:.....|..::  .:|.::|..||:.|:.||:..:.....|.
Zfish   602 RQFMTQMKSYLLQ------SSELDPPIESLIPED--QIDQVMEKAMHKCVLKPLKPVIEAALRDF 658

  Fly  1783 YQRSEDIQLLAQNVRYACEREAADFGIRPTVTPPSQAALRLIANLLWRLQEAELPLDKLELFLCV 1847
            ...|..:|.|.:|:..|..::..:.|: ....||...|:..|.:....:.:...|..|:.|.|.|
Zfish   659 QLSSGTMQQLKENLLLAKAKQPQEMGV-DGARPPDPVAIEKIRHKFNNMCKMYSPEKKVSLLLSV 722

  Fly  1848 ISTVFDATGCPRGQQLGADDFLPVLVYVVAKCGFVGAEIEAEFMWGLLQPTLLNGEPGYYLTALC 1912
            ...::.......|:..|||||||:|.||:|:|.....:.|.::|..||.|:||:||.|||||:..
Zfish   723 CKLIYTIMENNSGRMYGADDFLPMLTYVMAQCDMPELDTEIQYMMELLDPSLLHGEGGYYLTSAY 787

  Fly  1913 SAVQVLKTFMASE------GESGSGSLDW--RSSCLPACSSV------LRVIIPDECNGSLQTRT 1963
            .|:.::|.|...:      .|:.:....|  |.:......||      |||.:.|..:| ...:|
Zfish   788 GAMSLIKNFQEDQAARELSSETRNTLHQWHRRRTTQRTTPSVDDFQNYLRVALQDASSG-CTAKT 851

  Fly  1964 LPVRPHTTTREVCRIIAHKARITNPQDYALFKLVDGEETLLTDAECPQ 2011
            |.|:|:.||.:||:|.|.|.:|::|::||||.|.:.....||....||
Zfish   852 LQVQPYATTEDVCQICADKFKISDPENYALFLLTEETTQQLTLDTHPQ 899

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spri	NP_001259418.1	SH2	716..813	CDD:301589	28/99 (28%)
		VPS9	1821..1922	CDD:280383	35/100 (35%)
		UBQ	1946..2026	CDD:294102	28/72 (39%)
rin2a	XP_001345314.1	SH2	85..183	CDD:301589	30/101 (30%)
		VPS9	693..810	CDD:128469	38/116 (33%)
		Rin1_RA	835..921	CDD:176371	27/66 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584030
Domainoid	1	1.000	77	1.000	Domainoid score	I8754
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	248	1.000	Inparanoid score	I3238
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001291
OrthoInspector	1	1.000	-	-		otm25568
orthoMCL	1	0.900	-	-		OOG6_107356
Panther	1	1.100	-	-	O	PTHR23101
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3144
SonicParanoid	1	1.000	-	-		X2330
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.920