DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32687 and Lrrc58

DIOPT Version :9

Sequence 1:	NP_001259412.1	Gene:	CG32687 / 31980	FlyBaseID:	FBgn0052687	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_001182487.1	Gene:	Lrrc58 / 303919	RGDID:	1307440	Length:	366	Species:	Rattus norvegicus

Alignment Length:	378	Identity:	165/378 - (43%)
Similarity:	223/378 - (58%)	Gaps:	41/378 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LDFGRMSLDLVTLEDHLAS-------PQKALLKSSGDIETMLLNHNRLVGLPRLL-LQFGNLKIL 75
            |::.|:|:....||..|.:       .::|||:       :||.:|||..|||.| ..|.:|::|
  Rat    11 LNWSRLSVSAEALESELEARAEERRGSREALLR-------LLLPYNRLTSLPRALGSGFPHLQLL 68

  Fly    76 DLSSNAITTL-PDAVCQLPLVTLIAKNNLLTN-ASLPKSLLTKMANGNGNGNATGGTN---STLK 135
            |:|.||:|.| |:.:....|.||:|:||.|.. .||||.|               |.:   .:|:
  Rat    69 DVSGNALTALGPELLTLSGLRTLLARNNRLGGPGSLPKGL---------------GQSPLCRSLQ 118

  Fly   136 ELNLSGNQLTHFPEQVTELRHLKYLYLGGNKISSVSKDIWKMQSLHVLSLGGNLISEVPEAVGSL 200
            .||||||.....|..:.|||.|:.|.||||::.|:..:|..:|||..|.||||.|.|:|..:.:|
  Rat   119 VLNLSGNCFQELPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELANL 183

  Fly   201 NQLQALVLCDNLIEILPTSIARLKNLKSLLLHKNRLRHLPKDIVALKNLTELSLRDNPLVVRFVQ 265
            ..|..||||||.|:.:|..:::|.:|:||.||.|.|.:||::|:.|.:|.|||||.||||||||:
  Rat   184 PSLNYLVLCDNKIQSVPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLVVRFVR 248

  Fly   266 DMALKPPTLLELAGRMVKASGQRPGPYDIPRTLAEYLNSANCCVNPNCKGVFFDNRVEHIKFVDF 330
            |:...||||||||.|.:|.......|||:|..|..||.||:.|.||.|.||:||..|..||||||
  Rat   249 DLTYDPPTLLELAARTIKIRSISYTPYDLPGNLLRYLGSASNCPNPKCGGVYFDCCVRQIKFVDF 313

  Fly   331 CGKYRVPLLQYLCSSKCIEPEQPAARGSSVPAASAS------SGFMMRKVLLG 377
            |||||:||:.||||.:|..|...|:..|:..:.|.|      :...|:|||||
  Rat   314 CGKYRLPLMHYLCSPECSSPCSSASHSSTSQSESDSEDEASVAAHRMQKVLLG 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32687	NP_001259412.1	leucine-rich repeat	72..92	CDD:275380	9/20 (45%)
		leucine-rich repeat	94..133	CDD:275380	13/42 (31%)
		LRR_8	132..190	CDD:290566	27/57 (47%)
		LRR_4	134..171	CDD:289563	18/36 (50%)
		leucine-rich repeat	134..156	CDD:275380	10/21 (48%)
		leucine-rich repeat	157..179	CDD:275380	8/21 (38%)
		leucine-rich repeat	180..202	CDD:275380	10/21 (48%)
		LRR_8	202..259	CDD:290566	28/56 (50%)
		leucine-rich repeat	203..225	CDD:275380	10/21 (48%)
		leucine-rich repeat	226..248	CDD:275380	11/21 (52%)
Lrrc58	NP_001182487.1	LRR	<41..>242	CDD:227223	93/222 (42%)
		leucine-rich repeat	41..64	CDD:275380	12/29 (41%)
		leucine-rich repeat	65..87	CDD:275380	9/21 (43%)
		leucine-rich repeat	88..116	CDD:275380	13/42 (31%)
		leucine-rich repeat	117..139	CDD:275380	10/21 (48%)
		leucine-rich repeat	140..162	CDD:275380	8/21 (38%)
		leucine-rich repeat	163..185	CDD:275380	10/21 (48%)
		leucine-rich repeat	186..208	CDD:275380	10/21 (48%)
		leucine-rich repeat	209..231	CDD:275380	11/21 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340593
Domainoid	1	1.000	121	1.000	Domainoid score	I5596
eggNOG	1	0.900	-	-		E33208_3BCFH
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H14598
Inparanoid	1	1.050	269	1.000	Inparanoid score	I2945
OMA	1	1.010	-	-		QHG52401
OrthoDB	1	1.010	-	-		D382000at33208
OrthoFinder	1	1.000	-	-		FOG0005500
OrthoInspector	1	1.000	-	-		oto96457
orthoMCL	1	0.900	-	-		OOG6_106090
Panther	1	1.100	-	-	LDO	PTHR45752
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3919
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770