DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PPP4R2r and ppp4r2b

DIOPT Version :9

Sequence 1:	NP_525083.2	Gene:	PPP4R2r / 31979	FlyBaseID:	FBgn0030208	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	NP_001103841.1	Gene:	ppp4r2b / 100005419	ZFINID:	ZDB-GENE-030131-3008	Length:	426	Species:	Danio rerio

Alignment Length:	461	Identity:	121/461 - (26%)
Similarity:	208/461 - (45%)	Gaps:	89/461 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DEIMQILERFTDLKQKEIPKELEEYLQYVAKTGDTIFKWSSLKYLFREKLLSVIKHFNEDSPRLE 72
            |.:::.|:.|....:||....|:::|.::||||:|:..||..|..|..||..|::.|:..:|. :
Zfish     4 DTLLEALKDFDKKVKKEPSTVLDQFLCHIAKTGETLVSWSQFKTYFVFKLEKVMEDFHASAPE-Q 67

  Fly    73 EIPNYPNVDPFNYETMKSSLLERLDLFNAAPFTVQRLCELLIDPRKQYSRIDKFMRALEKNILVV 137
            ..|..|||:...:|.||..:|:.::.:|..|||:|||||||.:|::.|:..:||:|.:|||::||
Zfish    68 RGPANPNVESIPFEEMKERILKIVNEYNGIPFTIQRLCELLTEPKRNYTGTEKFLRGVEKNVMVV 132

  Fly   138 STIDPGRKRTESENGDSLDSVVNGDLSMEVNIDIEMENNNGNADEGSSPGAGSAGCAQKASCPRS 202
            |.|.|    |..:||.|..:.:||         :.:..|.....|....|.|:         ||
Zfish   133 SCIYP----TSEKNGCSGVNRMNG---------VMLSGNTSAFTERKVNGPGT---------PR- 174

  Fly   203 DDNDQPKAKKAKLEIDGEERSEASDETDT------------------EVATRVKNEK-DEKNDND 248
            ..|.|..:..:.|..:|...|..:.:|:|                  .:.:.|||:. |::.|..
Zfish   175 PLNRQKHSMSSSLATNGLPDSTENKDTNTLQGHSKTTSDASASGIGGPLGSSVKNKHLDDEEDEG 239

  Fly   249 ETDSPHEAAEIE------EPDEEVDEADQETKTTKQPAYGSQKEGEQEESFPSSADDEAEDP--- 304
            ..:..||...::      |.:|:.|:.|::...|.:            .:...|..|::|||
Zfish   240 MEEEEHEVKRLKFSQDGNEDEEDEDDVDEQVVETPR------------STLSKSPSDKSEDPESP 292

  Fly   305 --MVSKSIEAEKELVAQE---KKREEDKKVAIEPKEEIV-KKEEVVESDKPDGK---------VA 354
              |:.:..|.|:|....|   :..|:.:..:.:|:..:. .:|...|.:.|.|.         :.
Zfish   293 SSMLQEGSEEEEEESKHEGSAENSEDQEPSSTQPECPVADSRETFTEREVPCGSDDSSEEPSDMD 357

  Fly   355 QLGDKAVVKKSTPPADGENQEPVKVKAENEKEEKKHAPIKTEKQDDIDS-TETD------DAPSA 412
            |...:|....::.|...|.:||.:|.:.:..:   :|...|.....||| ||.|      |..||
Zfish   358 QSEQRAPAGVASSPELREGEEPSEVSSSSTDD---NASGPTSSSSSIDSPTEGDTGSGALDLESA 419

  Fly   413 EKPAEE 418
            |:|.|:
Zfish   420 EEPMEQ 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PPP4R2r	NP_525083.2	PPP4R2	10..292	CDD:286293	83/306 (27%)
ppp4r2b	NP_001103841.1	PPP4R2	6..>218	CDD:286293	71/235 (30%)
ppp4r2b	NP_001103841.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..426		61/290 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595881
Domainoid	1	1.000	120	1.000	Domainoid score	I5713
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I4392
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004686
OrthoInspector	1	1.000	-	-		oto41317
orthoMCL	1	0.900	-	-		OOG6_104211
Panther	1	1.100	-	-	LDO	PTHR16487
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3873
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.890