DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2887 and DNAJA3

DIOPT Version :9

Sequence 1:	NP_572633.1	Gene:	CG2887 / 31978	FlyBaseID:	FBgn0030207	Length:	342	Species:	Drosophila melanogaster
Sequence 2:	NP_005138.3	Gene:	DNAJA3 / 9093	HGNCID:	11808	Length:	480	Species:	Homo sapiens

Alignment Length:	386	Identity:	105/386 - (27%)
Similarity:	154/386 - (39%)	Gaps:	101/386 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KDYYKILGIQRTANDGEIRKAYHKQALRYHPDKNK-SPQAEEIFKQVAKAYEVLSDKKKRGSYDS 66
            :|||:|||:.|.|:..||:|||::.|.:||||.|| .|:|:|.|.|:|:|||||||:.||..||
Human    92 EDYYQILGVPRNASQKEIKKAYYQLAKKYHPDTNKDDPKAKEKFSQLAEAYEVLSDEVKRKQYD- 155

  Fly    67 RNDKGTRRNTANQGSGFGDGTAFGSCG---GGSGSGSGGGSGGGRQNNPRANFGRFFDNSESYST 128
                                 |:||.|   |.|||......||... :|...|.:.|  .|..|:
Human   156 ---------------------AYGSAGFDPGASGSQHSYWKGGPTV-DPEELFRKIF--GEFSSS 196

  Fly   129 FFEDIENDFDSDDDVLL-----GGGAGAPKR-------RCEQ-----QSPQSSIEHVIYV---AL 173
            .|.|.:..||...:..:     ....|..|.       .||:     ..|.:.::|..|.   .:
Human   197 SFGDFQTVFDQPQEYFMELTFNQAAKGVNKEFTVNIMDTCERCNGKGNEPGTKVQHCHYCGGSGM 261

  Fly   174 EDIANG-CNRRMKISRASGRNGV------------DGVQYDRILTVKIPPGCKAGTKICFPNEGI 225
            |.|..| ...|....|..||..:            ...|..|:: :.:|.|.:.|..:..|
Human   262 ETINTGPFVMRSTCRRCGGRGSIIISPCVVCRGAGQAKQKKRVM-IPVPAGVEDGQTVRMP---- 321

  Fly   226 QLPNLEPANVVFIIRDKPHPIFRRDGNNLLYTAEISLKDALCG-----------LHVMVPTLLGR 279
                :....:....|.:..|:|||||.::.....||:..||.|           ::|.:|.  |.
Human   322 ----VGKREIFITFRVQKSPVFRRDGADIHSDLFISIAQALLGGTARAQGLYETINVTIPP--GT 380

  Fly   280 PMELKTDVGEVISPKSVRRILGYGLPDSINNSRRGSIVVRFSIQFPDAISKELASSLDRLL 340
            ..:.|..:|            |.|:| .||:...|...:...|:.|    |.|.|....|:
Human   381 QTDQKIRMG------------GKGIP-RINSYGYGDHYIHIKIRVP----KRLTSRQQSLI 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2887	NP_572633.1	DnaJ	1..331	CDD:223560	101/375 (27%)
		DnaJ	4..65	CDD:278647	35/61 (57%)
		DnaJ_C	163..326	CDD:199909	39/189 (21%)
DNAJA3	NP_005138.3	DnaJ	90..480	CDD:223560	105/386 (27%)
		DnaJ	93..155	CDD:278647	35/61 (57%)
		DnaJ_C	207..416	CDD:199909	46/236 (19%)
		DnaJ_zf	236..296	CDD:199908	12/59 (20%)
		CXXCXGXG motif	236..243		2/6 (33%)
		CXXCXGXG motif	253..260		1/6 (17%)
		CXXCXGXG motif	275..282		2/6 (33%)
		CXXCXGXG motif	289..296		0/6 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..471
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910