DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2889 and CG15073

DIOPT Version :9

Sequence 1:	NP_001245615.1	Gene:	CG2889 / 31977	FlyBaseID:	FBgn0030206	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_611362.2	Gene:	CG15073 / 37155	FlyBaseID:	FBgn0034379	Length:	580	Species:	Drosophila melanogaster

Alignment Length:	598	Identity:	165/598 - (27%)
Similarity:	257/598 - (42%)	Gaps:	98/598 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MICRLCLRCLSPGSAVFLFETDDTLAETRLVKMIAKFLQLEILPDDGISTSVCTECCEHLEDFNG 65
            |||||||..::....:.:||  |......:..::||:...|...||.|||.:|..|...:.||:.
  Fly     1 MICRLCLNNVNDTDTIRIFE--DVGLSLNVANVLAKYFWFEPKSDDPISTVICLTCWNQVNDFHQ 63

  Fly    66 FWQLVEQKQCSLKKEFLTVDVDCAAMKWTGGVDVDVNIDELPLAAGDMDEKPLDLHNLSLLGSVL 130
            |:..||.....|.:.|                         .|.:|....|
  Fly    64 FYVAVESAHRLLTERF-------------------------SLKSGQDQGK-------------- 89

  Fly   131 DVNVDSVEVREPIKEQLPCEEEEDEKPCL------------------------QASDSEPEVTEG 171
                  ||..|..::|   |||:||...|                        |.:||.|...:.
  Fly    90 ------VEHGEDSEQQ---EEEQDEDQELGLPGSEGGSFTNEQFLTEVIAQQEQQTDSNPPKEQF 145

  Fly   172 QPESESDSSDDEPLVRLKSKMKPKRKTSARSSKDQG-PISLQQELADLLDDGGKRRRRKAPDQRT 235
            ..|..:..:|.|....|.::.:.:.:::|:|..... |.|...|.::.:.:..|.:|.....:.|
  Fly   146 IKEDNATVNDPETSATLPTEQRRETRSTAKSKAHHSLPPSTPPEKSNSVANKSKAKRTPCKAEGT 210

  Fly   236 TTESQE--SELQAVLERKPKGCSRAQLAKSYEKAIASYMSASCDLCEFSAPYLSELKTHFLEVHQ 298
            ..:|:.  ...|.:|:...|              |:::|..:||:|.........|..|.|:.|.
  Fly   211 PQKSKRYADYKQCMLDIDAK--------------ISAHMRLTCDVCHEGQETFLLLCKHMLQEHH 261

  Fly   299 REYYIKCCGKVFTRASKLMDHIRKHINPKLFTCTICKKSLNSQDYLATHIETVHNKVAQIGKVLK 363
            |:.|..||.|.|.:.|.|.|||.:|.:|:.|.||.|.|....:..|..|....|:...:    ..
  Fly   262 RKGYAICCNKKFYKRSFLTDHIDRHADPEKFKCTQCDKRFADKQCLRNHELLKHHPEEE----KT 322

  Fly   364 FPCPKCERTFSSERRMANHLAKHDTDQLEHTCEICCKSFANVHRLRRHIQSIHEDLHRHVCDICG 428
            |.|.:|.:.::.:..:..|...|....:  .|::|.:.|.|...|..|::..|.: :..:||||.
  Fly   323 FMCEQCPKRYTKQYLLDQHRVIHKERNV--VCDLCERRFPNQSLLCTHVKMAHGN-YGTMCDICA 384

  Fly   429 KKFKFKPSFERHLLEHQGVVAPAVECPICRVWLKNEHSLRLHRFTHDSTDTVCPHCGKTCTSRTA 493
            :..:.:.:|:||.|||.||..|.|:|.||..|.||:|||:.|...|:.|...|..|||...:|:|
  Fly   385 QVIRGRAAFQRHQLEHAGVTEPKVQCDICGSWHKNKHSLKKHVRRHNGTAATCDLCGKVSPNRSA 449

  Fly   494 LRGHVKYAHKLTTNLQCTFCEKTFKQQRNLDEHMAIHTGLQLYNCPHCPKECRSRSNMYVHIKQR 558
            :..|.:|.|......:|:.|.|.||:...|.|||.:|||..||.||||||...|.:|.:.|.::.
  Fly   450 MLSHQRYVHLTDRKHECSVCNKAFKKAITLREHMTMHTGEVLYKCPHCPKTFNSNANQHTHRRKC 514

  Fly   559 HADEWLRAKMARS 571
            |..|:..|:.||:
  Fly   515 HPKEFEEARKART 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2889	NP_001245615.1	zf-AD	2..79	CDD:285071	25/76 (33%)
		C2H2 Zn finger	276..297	CDD:275368	6/20 (30%)
		C2H2 Zn finger	306..323	CDD:275368	8/16 (50%)
		C2H2 Zn finger	331..352	CDD:275368	6/20 (30%)
		C2H2 Zn finger	366..386	CDD:275368	3/19 (16%)
		C2H2 Zn finger	395..416	CDD:275368	6/20 (30%)
		C2H2 Zn finger	424..444	CDD:275368	8/19 (42%)
		C2H2 Zn finger	481..502	CDD:275368	8/20 (40%)
		C2H2 Zn finger	510..530	CDD:275368	9/19 (47%)
		C2H2 Zn finger	538..556	CDD:275368	9/17 (53%)
CG15073	NP_611362.2	zf-AD	2..78	CDD:285071	25/77 (32%)
		C2H2 Zn finger	269..286	CDD:275368	8/16 (50%)
		C2H2 Zn finger	294..316	CDD:275368	6/21 (29%)
		C2H2 Zn finger	325..345	CDD:275368	3/19 (16%)
		C2H2 Zn finger	352..370	CDD:275368	6/17 (35%)
		C2H2 Zn finger	410..430	CDD:275368	10/19 (53%)
		C2H2 Zn finger	437..458	CDD:275368	8/20 (40%)
		C2H2 Zn finger	466..486	CDD:275368	9/19 (47%)
		C2H2 Zn finger	494..512	CDD:275368	9/17 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H134721
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG25790
OrthoDB	1	1.010	-	-		D28261at33392
OrthoFinder	1	1.000	-	-		FOG0000909
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.930