DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2889 and CG8388

DIOPT Version :9

Sequence 1:	NP_001245615.1	Gene:	CG2889 / 31977	FlyBaseID:	FBgn0030206	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_611075.1	Gene:	CG8388 / 36763	FlyBaseID:	FBgn0034062	Length:	572	Species:	Drosophila melanogaster

Alignment Length:	597	Identity:	161/597 - (26%)
Similarity:	265/597 - (44%)	Gaps:	109/597 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MICRLCLRCL--SPGSAVFLFETDDTLAETRLVKMIAKFLQLEILPDDGISTSVCTECCEHLEDF 63
            |.|.||.:.:  :.|:..|..|..|:|.   |..:|.|...|:| ||...:..||..|.|.|..|
  Fly     1 MPCFLCTQTVDDAAGNIEFASEEADSLG---LRCIIEKHFWLQI-PDSKRAGYVCGPCWEQLLLF 61

  Fly    64 NGFWQLVEQKQCSLKKEFLTVDVDCAAMKWTGGVDVDVNIDELPLAAGDMDE-----------KP 117
            :.|:..|||...:|::         ..:|.|...:|..:..|..:...:.|:           :|
  Fly    62 HNFYLNVEQAHKALEQ---------TVLKETSPPEVVASALEEHIVKSEHDDSVAAAVKRRRGRP 117

  Fly   118 LDLHNLSL---LGSVLD-VNVDSVEVREP-----IKEQLPCEEEEDEKP--CLQASDSE-PEVTE 170
            ..:.....   |.|||: :|::.:::..|     |.:.|..:||:|..|  |:....:| |||.|
  Fly   118 RKVAQQDAREELKSVLEQINLNEIKIEFPEADLTIADVLEDQEEQDFLPDDCISKEGAEDPEVLE 182

  Fly   171 GQPESESDSSDDEPLVRLKSKMKPKRKTSARSSKDQGPISLQQELADLLDDGGKRRRRKAPDQRT 235
            .:|          |.:        |||.|.||.                   |:||.:.|
  Fly   183 KKP----------PTL--------KRKVSGRSR-------------------GRRRVQLA----- 205

  Fly   236 TTESQESELQAVLERKPKGC-SRAQLAKSYEKAIASYMSASCDLCEFSAPYLSELKTHFLEVHQR 299
                         ||....| .:.|.::.:...|..:....|.:|.......||:..|....|::
  Fly   206 -------------ERPNTSCLPKIQKSQEFNDYIREHYKVQCHICNLPMEDFSEMLAHVRREHKQ 257

  Fly   300 EYYIKCCGKVFTRASKLMDHIRKHINPKLFTCTICKKSLNSQDYLATHIETVHNKVAQIGKVLKF 364
            ..|..||.:.|.:...|:||:|:|.:|:.|.|:||.:.:..:..|..|:..  :::...|::  :
  Fly   258 RGYAMCCNRKFLKRGVLVDHLRRHQDPETFKCSICGRVMGHRRSLELHMRM--HEIKSRGRL--Y 318

  Fly   365 PCPKCERTFSS----ERRMANHLAKHDTDQLEHTCEICCKSFANVHRLRRHIQSIHEDLHRHVCD 425
            .|.:|.:.|.|    ||....|:.:   :|.:..|..|.|::.:.:.:::|::.:|.:|:..:||
  Fly   319 RCEQCSKAFYSAVVYERHKLTHIPR---EQWKVPCTHCEKTYPSQYTMQQHVKLVHLNLYAKICD 380

  Fly   426 ICGKKFKFKPSFERHLLEHQGVVAPAVECPICRVWLKNEHSLRLH-RFTHDSTD---TVCPHCGK 486
            :|||..:.:.:..||:.||.|....|::|.:|...|..::.|..| :..|.:.:   ..|..|.|
  Fly   381 VCGKSIRGREALARHMEEHTGGPQAAIKCHLCDSMLTTKYGLARHIKMMHTAENLQPMQCEFCLK 445

  Fly   487 TCTSRTALRGHVKYAHKLTTNLQCTFCEKTFKQQRNLDEHMAIHTGLQLYNCPHCPKECRSRSNM 551
            .|.|..|.:.|:||.|....:.||..|||.||:...|.|||..|||..||.|||||:...|.:||
  Fly   446 ICPSLQAHQHHIKYTHNTARSHQCPMCEKAFKRPNELKEHMTTHTGEVLYTCPHCPQTFNSNANM 510

  Fly   552 YVHIKQRHADEW 563
            :.|.|:.|..||
  Fly   511 HAHRKKVHRKEW 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2889	NP_001245615.1	zf-AD	2..79	CDD:285071	26/78 (33%)
		C2H2 Zn finger	276..297	CDD:275368	5/20 (25%)
		C2H2 Zn finger	306..323	CDD:275368	6/16 (38%)
		C2H2 Zn finger	331..352	CDD:275368	5/20 (25%)
		C2H2 Zn finger	366..386	CDD:275368	7/23 (30%)
		C2H2 Zn finger	395..416	CDD:275368	4/20 (20%)
		C2H2 Zn finger	424..444	CDD:275368	7/19 (37%)
		C2H2 Zn finger	481..502	CDD:275368	9/20 (45%)
		C2H2 Zn finger	510..530	CDD:275368	10/19 (53%)
		C2H2 Zn finger	538..556	CDD:275368	9/17 (53%)
CG8388	NP_611075.1	zf-AD	<21..77	CDD:285071	21/59 (36%)
		C2H2 Zn finger	264..281	CDD:275368	6/16 (38%)
		C2H2 Zn finger	289..309	CDD:275368	5/21 (24%)
		C2H2 Zn finger	320..340	CDD:275368	6/19 (32%)
		C2H2 Zn finger	350..369	CDD:275368	4/18 (22%)
		C2H2 Zn finger	440..461	CDD:275368	9/20 (45%)
		C2H2 Zn finger	469..489	CDD:275368	10/19 (53%)
		C2H2 Zn finger	497..515	CDD:275368	9/17 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H134721
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D28261at33392
OrthoFinder	1	1.000	-	-		FOG0000909
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920