DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2889 and CG1663

DIOPT Version :9

Sequence 1:	NP_001245615.1	Gene:	CG2889 / 31977	FlyBaseID:	FBgn0030206	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_610521.1	Gene:	CG1663 / 36012	FlyBaseID:	FBgn0033449	Length:	387	Species:	Drosophila melanogaster

Alignment Length:	444	Identity:	92/444 - (20%)
Similarity:	149/444 - (33%)	Gaps:	96/444 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 GVDVDVNIDELPLAAGDMDEKPLDLHNLSLLGSVLDVNVDSVEVREPIKEQLPCEEEEDEKPCLQ 160
            |.:...|.||..:    .||..:::.|  ||.:.:.......||:|..|.....|||.:
  Fly     9 GNESGFNADEDEI----QDEVQVEMTN--LLAASIAQESKLAEVQESFKNVEFMEEEVE------ 61

  Fly   161 ASDSEPEVTEGQPESESDSSDDEPLVRLKSKMKPKRKTSARSSKDQGPISLQQELADL------- 218
             .:..||..:|..|..|:|..|....:........::||        |..:|..:..|
  Fly    62 -PNFSPEKEQGHDELASNSHHDYISNQPHKAFYSLQRTS--------PGVIQYFIQQLRRHKFFW 117

  Fly   219 LDDGGKRRRRKAPDQRTTTESQESELQAVLERKPKGCSRAQLAKSYEKAIASYMSASCDLCEFSA 283
            :.:.|..::.:....:...|:........|:.|....|...|...:|:.....:|:|...|.:..
  Fly   118 ITEHGINKKDRMDSSQKVAEALFHRFHFQLDPKVVNASARFLQVWFERQYVMQLSSSDFRCRYPK 182

  Fly   284 PYLSELKTHFLEVHQREYYIKCCGKVFTRASKLMDHIRKHINPKLFTCTICKKSLNSQDYLATHI 348
            .|.|.||  |:..:                         ||     :.|||:
  Fly   183 YYHSLLK--FMPTN-------------------------HI-----SVTICE------------- 202

  Fly   349 ETVHNKVAQIGKVLKFPCPKCERTFSSERRMANHLAKHDTDQLEHTCEICCKSFANVHRLRRHIQ 413
                               :|:|.|.:||.:..|..:.......:.|.:|.:||....:|.:|..
  Fly   203 -------------------ECDRRFLNERLLRLHKFRVHGGPNPNVCHVCHQSFPLASKLEQHQA 248

  Fly   414 SIHEDLHRHVCDICGKKFKFKPSFERHLLEHQGVVAPAVECPICRVWLKNEHSLRLHRFTHDSTD 478
            ..|.......|..|......|..|::|...|.|  .....|.:|....|...:|.:||.|||...
  Fly   249 RYHFKRPEWQCSRCDYNAPSKWDFQQHQAMHAG--QRNYICELCGHSSKTSSALAVHRRTHDQPK 311

  Fly   479 TVCPHCGKTCTSRTALRGHVKYAH--KLTTNLQCTFCEKTFKQQRNLDEHMAIH 530
            ..||||.:.....:.|:.|::..|  .....:.|.||.:.||....|..|..:|
  Fly   312 LCCPHCSRQFRENSTLKSHIRKIHDGNSARQVSCDFCWRRFKTLELLKLHKLVH 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2889	NP_001245615.1	zf-AD	2..79	CDD:285071
		C2H2 Zn finger	276..297	CDD:275368	6/20 (30%)
		C2H2 Zn finger	306..323	CDD:275368	0/16 (0%)
		C2H2 Zn finger	331..352	CDD:275368	3/20 (15%)
		C2H2 Zn finger	366..386	CDD:275368	6/19 (32%)
		C2H2 Zn finger	395..416	CDD:275368	6/20 (30%)
		C2H2 Zn finger	424..444	CDD:275368	5/19 (26%)
		C2H2 Zn finger	481..502	CDD:275368	6/20 (30%)
		C2H2 Zn finger	510..530	CDD:275368	7/19 (37%)
		C2H2 Zn finger	538..556	CDD:275368
CG1663	NP_610521.1	MttA_Hcf106	<33..>91	CDD:294511	15/64 (23%)
		C2H2 Zn finger	201..222	CDD:275368	7/52 (13%)
		C2H2 Zn finger	259..279	CDD:275368	5/19 (26%)
		C2H2 Zn finger	287..307	CDD:275368	6/19 (32%)
		C2H2 Zn finger	314..335	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469318
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930