DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2889 and CG12219

DIOPT Version :9

Sequence 1:	NP_001245615.1	Gene:	CG2889 / 31977	FlyBaseID:	FBgn0030206	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_572312.1	Gene:	CG12219 / 31572	FlyBaseID:	FBgn0043796	Length:	562	Species:	Drosophila melanogaster

Alignment Length:	695	Identity:	160/695 - (23%)
Similarity:	234/695 - (33%)	Gaps:	285/695 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MICRLCLRCLSPGSAVFLF------------ETDD--TLAETRLVKMIAKFLQLEILPDDGISTS 51
            |||||||..|...|||.||            :.||  .:.|:.||::|:..|.|.:..||.|||.
  Fly     1 MICRLCLNALDEQSAVLLFDGAGGASAPAPDDEDDGKAMPESYLVQLISIHLYLCLSRDDAISTC 65

  Fly    52 VCTECCEHLEDFNGFWQLVEQKQCSLKKEFLTVDVDCAAMKWTGGVDVDVNIDELPLAAGDMDEK 116
            :|||||..||.|:.||:|||.||.:|..:||.  :||           |||..|      |..|.
  Fly    66 ICTECCSQLESFHNFWKLVELKQTTLCSQFLA--IDC-----------DVNWSE------DGSET 111

  Fly   117 PLDLHNLSLLGSVLDVNVDSVEVREPIKE-QLPCEEEEDEKPCLQASDSEPEVTEGQPESESDSS 180
            .||.....||              ||.:| ::......::.||:....|. ::.....|..:..:
  Fly   112 QLDAQPQLLL--------------EPAEEPKVVTPTTANKFPCMFCEKSF-KMRRYLEEHIATHT 161

  Fly   181 DDEPLV--------RLKSKM----KPKRKT---SARSSKDQGPISLQQELADLLDDGGKRRRRKA 230
            .|.|:.        |.:|.|    |.|..|   .||..:|..                     |:
  Fly   162 GDRPIACPYCEMAFRCRSNMYTHVKSKHTTQWLKAREERDAA---------------------KS 205

  Fly   231 PDQRTTTESQESELQAVLERKPKGCSRAQLAKSYEKAIASYMSASCDLCEFSAPYLSELKTHFLE 295
            ....||   .|....|||...|          :...|:||..::|      ::|
  Fly   206 NQNHTT---PEETAPAVLVPVP----------APAPALASAPASS------ASP----------- 240

  Fly   296 VHQREYYIKCCGKVFTRASKLMDHIRKHINPKLFTCTICKKSLNSQDYLATHI---ETVHNKVAQ 357
                       |..              :||.. |.|....:..:.:..|..:   .||......
  Fly   241 -----------GNT--------------VNPAA-TATPASSATPTTNLAAAPLPSPPTVQQLPLS 279

  Fly   358 IGK----------VLKFPCPKCERTFSSERRMANHLAKHDTDQLEHTCEICCKSFANVHRLRRHI 412
            :.|          :.|.| |...|   ..|..::....|...:::||
  Fly   280 VIKSQPSEAMNLTITKTP-PSGSR---GSRNRSSRRKTHSPKKVQHT------------------ 322

  Fly   413 QSIHEDLHRHVCDICGKKFKFKPSFERHLLEHQ-----------GVVAPA------------VEC 454
                          .|.....:.|.::.|.|::           .|||.|            ::.
  Fly   323 --------------EGSDVSDEDSPQKRLKENELILANYNAVAAAVVAAASLTGNPPGQPDSLQQ 373

  Fly   455 PICRVWLKNEHSLRL--------------------------------HRF-THDSTDT------- 479
            .:|...|:.:|..:|                                |.: .|..::|
  Fly   374 RLCASLLQQQHQEQLFAVMSATAAAAAAVGTSSATTTTTTTTGTMMAHPYGNHPPSETDKRPAAP 438

  Fly   480 ------------VCPHCGK------TCTSRTALRGHVKYAHKLTTNLQCTFCEKTFKQQRNLDEH 526
                        :||:||:      .|.|:.      |||        |..|.|:||.:|.|:||
  Fly   439 LQAVIHAAPVSIICPNCGELPGQNHRCLSKP------KYA--------CDVCGKSFKMKRYLEEH 489

  Fly   527 MAIHTGLQLYNCPHCPKECRSRSNMYVHIKQRHADEWLRAKMARS 571
            .|.|||::|:.|..||.|.||:||||.|.|::|..||.|::..||
  Fly   490 FATHTGVKLHTCAFCPTEFRSKSNMYHHTKRKHKAEWERSRATRS 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2889	NP_001245615.1	zf-AD	2..79	CDD:285071	41/90 (46%)
		C2H2 Zn finger	276..297	CDD:275368	1/20 (5%)
		C2H2 Zn finger	306..323	CDD:275368	1/16 (6%)
		C2H2 Zn finger	331..352	CDD:275368	3/23 (13%)
		C2H2 Zn finger	366..386	CDD:275368	3/19 (16%)
		C2H2 Zn finger	395..416	CDD:275368	0/20 (0%)
		C2H2 Zn finger	424..444	CDD:275368	3/19 (16%)
		C2H2 Zn finger	481..502	CDD:275368	8/26 (31%)
		C2H2 Zn finger	510..530	CDD:275368	10/19 (53%)
		C2H2 Zn finger	538..556	CDD:275368	11/17 (65%)
CG12219	NP_572312.1	zf-AD	2..94	CDD:285071	41/91 (45%)
		C2H2 Zn finger	140..160	CDD:275368	3/20 (15%)
		COG4049	149..204	CDD:226535	12/75 (16%)
		C2H2 Zn finger	168..186	CDD:275368	3/17 (18%)
		C2H2 Zn finger	473..493	CDD:275370	10/19 (53%)
		C2H2 Zn finger	501..522	CDD:275370	12/20 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	0.196	Domainoid score	I19326
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000909
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.000