DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2889 and Zfy2

DIOPT Version :9

Sequence 1:	NP_001245615.1	Gene:	CG2889 / 31977	FlyBaseID:	FBgn0030206	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_033597.2	Gene:	Zfy2 / 22768	MGIID:	99213	Length:	777	Species:	Mus musculus

Alignment Length:	718	Identity:	156/718 - (21%)
Similarity:	242/718 - (33%)	Gaps:	223/718 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LFETD--------------DTLAETRLVKMIAKFLQLEILPDDGISTS------VCTECCEHLED 62
            |.|||              ||..|..|    |:||..:||.....|||      |......|:.:
Mouse    80 LEETDISDNVIIPEQVLDLDTAEEVSL----AQFLIPDILTSSITSTSLTMPEHVLMSEAIHVSN 140

  Fly    63 FNGFWQLVEQKQCSLKKEF----LTVDV-DCAAMKWTGGVDVDVNIDELPLAAGD---------- 112
            ...|.|::...  .:::|.    ||.|: |.....|.....:|.:  .:||...|
Mouse   141 VGHFEQVIHDS--LVEREIITDPLTADISDILVADWASEAVLDSS--GMPLEQQDDARINCEDYL 201

  Fly   113 ---MDEKPLDLHNLSLLGSVLDVNVDSVEVREPIKEQLP-----C-----EEEEDEKPCLQASDS 164
               :||.....|..|   |.:.:|.:|......:.|..|     |     .|.:|....:||.:|
Mouse   202 MMSLDEPSKTDHEGS---SEVTMNAESETDSSKLDEASPEVIKVCILKADSEVDDVGETIQAVES 263

  Fly   165 ------EPEVTEGQ--------------PESESDSSDDEPLV----------------------R 187
                  |.|||:.:              .:|:.:..|.:.:|                      .
Mouse   264 ETDNGNEAEVTDQRTSIHVPRVNIYMLASDSQKEEEDTKVIVGDEDAGGTAADTPEHEQQMDVSE 328

  Fly   188 LKSKMKPKRKTSARSSKDQGPISLQQELADLL----DDGG---------KRRRRK---------- 229
            :|:...|...|:|..: :...|.:|...|..:    :.||         |:::|.
Mouse   329 IKAAFLPIAWTAAYDN-NSDEIEVQNATASAMLHHDESGGLDRVPKQKSKKKKRPESKQYQSAIF 392

  Fly   230 -APDQRT------------------------------------TTE-------------SQESEL 244
             |||.:|                                    .||             ..||..
Mouse   393 VAPDGQTLRVYPCMFCGKKFKTKRFLKRHIKNHPEYLANKKYHCTECDYSTNKKISLHNHMESHK 457

  Fly   245 QAVLERKPKGCSRAQLAKSY------EKAIASYMSASCDLCEFSAPYLSELKTHFLEVHQREYYI 303
            ..:...|...|...:...|:      ||.:..  :..|..|::.....:.|..|.|.||::::..
Mouse   458 LTIKTEKTTECDDCRKNLSHAGTMHTEKGVNK--TCKCKFCDYETAEQTLLNHHLLVVHRKKFPH 520

  Fly   304 KC--CGKVFTRASKLMDHIRKHINPKLFTCTICK-KSLNSQDYLATHIETVHNKVAQIGKVLKFP 365
            .|  |||.|...|.|..|||.|...|.:.|..|: ||.:|.: |.|||::.|:      |.:...
Mouse   521 ICGECGKGFRHPSALKKHIRVHTGEKPYECQYCEYKSADSSN-LKTHIKSKHS------KEIPLK 578

  Fly   366 CPKCERTFSSERRMANHLAKHDTDQLEHTCEICCKSFANVHRLRRHIQSIHEDLHRHVCDICGKK 430
            |..|..|||..:....|...|. :...|.|..|....:|...|:|||.|:|...:.|.||:|.|.
Mouse   579 CGICLLTFSDTKEAQQHAVLHQ-ESRTHQCSHCNHKSSNSSDLKRHIISVHTKAYPHKCDMCSKG 642

  Fly   431 FKFKPSFERHLLEHQGVVAPAVECPICRVWLKNEHSLRLHRFTHDSTDTVCPHCGKTCTSRTALR 495
            |......::|:..|:                    |.::|:         |.||.........|.
Mouse   643 FHRPSELKKHVATHK--------------------SKKMHQ---------CRHCDFKSPDPFLLS 678

  Fly   496 GHVKYAHKLTTNLQCTFCEKTFKQQRNLDEHMAIHTGLQLYNCPHCPKECRSRSNMYVHIKQRHA 560
            .|:..||......:|..|:|.|:||..|..||..|:..::|.|.:|....:..|....|:...|.
Mouse   679 HHILSAHTKNVPFKCKRCKKEFQQQCELQTHMKTHSSRKVYQCEYCEYSTKDASGFKRHVISIHT 743

  Fly   561 DEW 563
            .::
Mouse   744 KDY 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2889	NP_001245615.1	zf-AD	2..79	CDD:285071	20/80 (25%)
		C2H2 Zn finger	276..297	CDD:275368	5/20 (25%)
		C2H2 Zn finger	306..323	CDD:275368	9/16 (56%)
		C2H2 Zn finger	331..352	CDD:275368	9/21 (43%)
		C2H2 Zn finger	366..386	CDD:275368	6/19 (32%)
		C2H2 Zn finger	395..416	CDD:275368	8/20 (40%)
		C2H2 Zn finger	424..444	CDD:275368	6/19 (32%)
		C2H2 Zn finger	481..502	CDD:275368	5/20 (25%)
		C2H2 Zn finger	510..530	CDD:275368	9/19 (47%)
		C2H2 Zn finger	538..556	CDD:275368	4/17 (24%)
Zfy2	NP_033597.2	Zfx_Zfy_act	68..388	CDD:282547	63/319 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	207..234		6/29 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	361..389		4/27 (15%)
		Nuclear localization signal. /evidence=ECO:0000255	372..382		1/9 (11%)
		C2H2 Zn finger	405..425	CDD:275370	0/19 (0%)
		C2H2 Zn finger	436..456	CDD:275368	3/19 (16%)
		COG5048	<442..681	CDD:227381	68/277 (25%)
		C2H2 Zn finger	493..514	CDD:275368	5/20 (25%)
		zf-C2H2	520..542	CDD:278523	10/21 (48%)
		C2H2 Zn finger	522..542	CDD:275368	10/19 (53%)
		zf-H2C2_2	534..556	CDD:290200	8/21 (38%)
		C2H2 Zn finger	550..571	CDD:275368	9/21 (43%)
		C2H2 Zn finger	579..599	CDD:275368	6/19 (32%)
		C2H2 Zn finger	607..628	CDD:275368	8/20 (40%)
		C2H2 Zn finger	636..685	CDD:275368	14/77 (18%)
		C2H2 Zn finger	693..713	CDD:275368	9/19 (47%)
		C2H2 Zn finger	721..742	CDD:275368	4/20 (20%)
		C2H2 Zn finger	750..770	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000