Protein Alignment nocte and PRRC2C

DIOPT Version :9

• Sequence 1: NP_001245614.1
• Gene: nocte / 31976
• FlyBaseID: FBgn0261710
• Length: 2309
• Species: Drosophila melanogaster
• Sequence 2: XP_005245072.1
• Gene: PRRC2C / 23215
• HGNCID: 24903
• Length: 2903
• Species: Homo sapiens
• Alignment Length: 2903
• Identity: 523/2903 - (18%)
• Similarity: 849/2903 - (29%)
• Gaps: 1213/2903 - (41%)

  Fly     1 MSTLGGSRGERNAKPKFTALDINRMYKNSRGESSEPSAQKNQVPRKHGMQILGKVPSARR--PPA 63
            ||...|...:.....|:..|.:...||   |:|.|  .||..|..:||:|.||||..:||  |||
Human     1 MSEKSGQSTKAKDGKKYATLSLFNTYK---GKSLE--TQKTTVAARHGLQSLGKVGISRRMPPPA 60

  Fly    64 NLPSLKAETHTSSNNNLLVSVEGATSGGAGAGGAAGSGAAGTNTSHNNTTAHSGSSGTSGGAGSG 128
            ||||||||...:..|..:|..:|.
Human    61 NLPSLKAENKGNDPNVNIVPKDGT----------------------------------------- 84

  Fly   129 GGGTASSSAGGHLSQQLTHSQHQHNNNVALGPNAGKFVNSNNGSSNNNAGSSGSGNKNFKLINNS 193
                      |..|:|   .||:......:.|...|
Human    85 ----------GWASKQ---EQHEEEKTPEVPPAQPK----------------------------- 107

  Fly   194 VGSSGGGGQGGSGGGGSSGVGGGSGSGSGGHSVNSPKTWSAITTGHERGSGGQNYGRQQQQVVPH 258
                                   .|..:......:||:|::      ...|||..|.|
Human   108 -----------------------PGVAAPPEVAPAPKSWAS------NKQGGQGDGIQ------- 136

  Fly   259 YQSPQFQYEFPTLDGTVGSGAGGGSGAGVGSGSGAGKSHYQNQVHHAGHQNHHQHQQHHQQHQQH 323
             .:.|||.|||:|..                               ||.|
Human   137 -VNSQFQQEFPSLQA-------------------------------AGDQ--------------- 154

  Fly   324 HHQQQQHHRDYHHGHGRQYGHHSHRDYRDGSDDVGGGSADLGELSLRPQNDTAAWLQQQEKAAKV 388
             .::::...|.::|.|......:...:|||....|..|:...:..|..|:::.|...:|....||
Human   155 -EKKEKETNDDNYGPGPSLRPPNVACWRDGGKAAGSPSSSDQDEKLPGQDESTAGTSEQNDILKV 218

  Fly   389 AAAAAADQGLNLQGPGHHQMGGNGGAGGGSGGAVPLPILSLMPSFMRSGAPMPASGATAASILAG 453
            .....|      .||...::       .|...|:.....::||.:|....|
Human   219 VEKRIA------CGPPQAKL-------NGQQAALASQYRAMMPPYMFQQYP-------------- 256

  Fly   454 GSLDTSALPNAPYQNGILGARSASPAVVGSGSFRAATAIPKRPPTSSSPPQSGL-GIGGSPTPPQ 517
                                |...|.:.|          |.|.|.|.|....|| |.|    ||.
Human   257 --------------------RMTYPPLHG----------PMRFPPSLSETNKGLRGRG----PPP 287

  Fly   518 SQQQANGGAGGAGRKDKDYVVEPEVAQMQRPII------REED-LERLNAIAKDDSWT-KQDDID 574
            |                 :..|||     ||.|      :|.| .:.|:|.| |:.|. .|.::|
Human   288 S-----------------WASEPE-----RPSILSASELKELDKFDNLDAEA-DEGWAGAQMEVD 329

  Fly   575 FTKKLAFSDDE----STPEEH--QGQGKQ-----------------HSSAQLQAQ---------- 606
            :|::|.||||:    ::|:|:  :.||.:                 .||:|:.||
Human   330 YTEQLNFSDDDEQGSNSPKENNSEDQGSKASENNENKKETDEVSNTKSSSQIPAQPSVAKVPYGK 394

  Fly   607 --------GSSS--------------------------------------------STDQRKLSA 619
                    |:||                                            ...|.::||
Human   395 GPSFNQERGTSSHLPPPPKLLAQQHPPPDRQAVPGRPGPFPSKQQVADEDEIWKQRRRQQSEISA 459

  Fly   620 STTSWQRGKESTDR-------------------------DQPS---------EGIQDQQQQLQQQ 650
            :....::.:|..:|                         .|||         |..::::::|:::
Human   460 AVERARKRREEEERRMEEQRKAACAEKLKRLDEKLGILEKQPSPEEIREREREKEREREKELEKE 524

  Fly   651 QQQQEVRQQNGHRGSSGNVGAPVAGGIALDASVYERVKQR-----KEEEERREM--ERKQAAAKK 708
            |:|:..:::...|                     ||.:::     ||:|::|||  ||||...|:
Human   525 QEQEREKEREKDR---------------------ERQQEKEKELEKEQEKQREMEKERKQEKEKE 568

  Fly   709 L--------------------------QELEMKMNSKKAAAAALA---GAEGGVSSASVPL---- 740
            |                          ::||.|:..::.....:.   .:|...:....|:
Human   569 LERQKEKEKELQKMKEQEKECELEKEREKLEEKIEPREPNLEPMVEKQESENSCNKEEEPVFTRQ 633

  Fly   741 -SNEVPPTSAPLGNASEDEGGGQGGGGGLNRRPRGSISSLGSGVTPTGGAGGGGGGVSSSSSAGG 804
             ||.....:.|:.:.:|.|.|.|         ||.::.|
Human   634 DSNRSEKEATPVVHETEPESGSQ---------PRPAVLS-------------------------- 663

  Fly   805 DYGQKNFLTHFQSNLPPRFQRQQ--------QQQQQQ--LPRLEKSASASS-------------- 845
                 .:...||.:|||||||||        ||||||  ||:...|..:||
Human   664 -----GYFKQFQKSLPPRFQRQQEQMKQQQWQQQQQQGVLPQTVPSQPSSSTVPPPPHRPLYQPM 723

  Fly   846 ----------AFDSN----SRYLQKGGVSGGGG----GVSGGA----------QANAGQGRSISG 882
                      .||..    ..|:....:||...    .:..|.          |.......|.|.
Human   724 QPHPQHLASMGFDPRWLMMQSYMDPRMMSGRPAMDIPPIHPGMIPPKPLMRRDQMEGSPNSSESF 788

  Fly   883 GYVQRGA-----------SVGGSSGY----------GRNRHDSSSAREDQDLDQQRFTRGQ--DY 924
            .::.|.|           .:.||..|          .:...:....|.:..|||::.|...  ::
Human   789 EHIARSARDHAISLSEPRMLWGSDPYPHAEPQQATTPKATEEPEDVRSEAALDQEQITAAYSVEH 853

  Fly   925 RQAQALPRS--ISENSHRKTS--VSSAGDDVL--------GGSC----------SSWAEQTDAEQ 967
            .|.:|.|::  |.|:|..:..  :|.:.:||.        ..:|          :...|:..|.:
Human   854 NQLEAHPKADFIRESSEAQVQKFLSRSVEDVRPHHTDANNQSACFEAPDQKTLSAPQEERISAVE 918

  Fly   968 KVHHRHREESFSSSH--------SHDSAVQIKI----------LQRPARQPS------------- 1001
            ....|.|..|..|:|        |..||...|:          ::||..:|.
Human   919 SQPSRKRSVSHGSNHTQKPDEQRSEPSAGIPKVTSRCIDSKEPIERPEEKPKKEGFIRSSEGPKP 983

  Fly  1002 ---LSEESSTQQKQLPASPQQQK-----TLTTDPMPTQILR-----RSVDIDKSGD--------- 1044
               ...:|.|:....|:|.::::     ...:.|:...:||     |....:|.|:
Human   984 EKVYKSKSETRWGPRPSSNRREEVNDRPVRRSGPIKKPVLRDMKEEREQRKEKEGEKAEKVTEKV 1048

  Fly  1045 ----ERAEDK------------------------------------------------------S 1051
                |:.|.|                                                      |
Human  1049 VVKPEKTEKKDLPPPPPPPQPPAPIQPQSVPPPIQPEAEKFPSTETATLAQKPSQDTEKPLEPVS 1113

  Fly  1052 ALESDDKAKSAGK-------VEEDKSGNKRVS---------PRSGAACGGRG------------- 1087
            .::.:...|:..:       |:|:|...|.:|         |.|..|.....
Human  1114 TVQVEPAVKTVNQQTMAAPVVKEEKQPEKVISKDLVIERPRPDSRPAVKKESTLPPRTYWKEARE 1178

  Fly  1088 -----GRGYAGSSGGSSVGSGSSYRGQRNASDWGSSRGSGGAGGRRYY-------------GSGG 1134
                 .:||.|...|.....|.||||     .:| .||.||.|..|.|             .||.
Human  1179 RDWFPDQGYRGRGRGEYYSRGRSYRG-----SYG-GRGRGGRGHTRDYPQYRDNKPRAEHIPSGP 1237

  Fly  1135 -EQSEHSE----------------------DVDEECYSSGG-------GGAARRS--PKESGNGA 1167
             .|.|.||                      |.|.|.:.|..       |...:|.  |:......
Human  1238 LRQREESETRSESSDFEVVPKRRRQRGSETDTDSEIHESASDKDSLSKGKLPKREERPENKKPVK 1302

  Fly  1168 PNSGASAN---------------------KAGFSPRGEPSRRGRGGLSSGGGASASCYRRQPVGT 1211
            |:|....:                     |.||.|:|||:||||||....||       |.|
Human  1303 PHSSFKPDNHVRIDNRLLEKPYVRDDDKAKPGFLPKGEPTRRGRGGTFRRGG-------RDP--- 1357

  Fly  1212 GSAGGSGSGGSGRSYGRLGYEEYGKQQRTSE----SETDLDKTKQNQLALSAGLHKPSKDDKDLP 1272
               ||..|..|  :..|..|.:.....|.||    .:.:..:..:..:.::|....|..:.|..|
Human  1358 ---GGRPSRPS--TLRRPAYRDNQWNPRQSEVPKPEDGEPPRRHEQFIPIAADKRPPKFERKFDP 1417

  Fly  1273 ALGGEEKDKTAALAPAHNTALLAKDELQKDAAGRLPLPPGLAAPGSAVGSVTATSSSVVVPGAAD 1337
            |.....:.:... .|..:.....:...:::||.:                    |:.||.
Human  1418 ARERPRRQRPTR-PPRQDKPPRFRRLREREAASK--------------------SNEVVA----- 1456

  Fly  1338 KKKIESCAVVGGEKVTGSKLPAIGEKTSLGAVGSGPSTSLLLDAGAPVNTIIFENSTYKQQAAAA 1402
                               :|..|...::              |..||||:
Human  1457 -------------------VPTNGTVNNV--------------AQEPVNTL-------------- 1474

  Fly  1403 SVVTKPGTLSVSSSGATMTVDSLSSALSQMSFGGKATAAGSGDDSQDMKLGFSFGDDPTTPLKVV 1467
                  |.:|                       |..|...|..:|.|.
Human  1475 ------GDIS-----------------------GNKTPDLSNQNSSDQ----------------- 1493

  Fly  1468 DNIDKTASQQQQQQQQQHSQQQQQQQQQQNNSTADLNMKIASVKKVWESATPMSDGPSPAQVQQQ 1532
                  |:::.:...:.....:::::.::.|  ||||.:  :|.||.|:..|
Human  1494 ------ANEEWETASESSDFNERRERDEKKN--ADLNAQ--TVVKVGENVLP------------- 1535

  Fly  1533 QQQQPQQQQQSQVQVAAQQQQQQVVGPQQAGDDGSG-HMSAASFVAAVAASQHQQQHQQMPHYAV 1596
            .:::..::..|..:...:|.::...||.::|.:.|| .....|...:.:..:.....|......|
Human  1536 PKREIAKRSFSSQRPVDRQNRRGNNGPPKSGRNFSGPRNERRSGPPSKSGKRGPFDDQPAGTTGV 1600

  Fly  1597 SAVHMQSHHHQQQQQQQQAAVAAAQAQHHQQQQAQAHHQHHALSSPGPVPGSHGHGYSHGSPFDA 1661
            ..::..|.|||:       .|.....|.:.:.......:     .|.|.|..........|.||.
Human  1601 DLINGSSAHHQE-------GVPNGTGQKNSKDSTGKKRE-----DPKPGPKKPKEKVDALSQFDL 1653

  Fly  1662 GSLEQQFQQEDYP------SPQQQQQAHQKTKQLQQQQHLGMSPPPSQQQQQQHSQQQQ--QAQH 1718
            .:.......:|:|      .||........|:.:.::|...:      |.:::..:::|  |..:
Human  1654 NNYASVVIIDDHPEVTVIEDPQSNLNDDGFTEVVSKKQQKRL------QDEERRKKEEQVIQVWN 1712

  Fly  1719 QQQQQQAHQQQQQQQQPSF--------YQASPQFGVGGIPTIPSPPAVVYNSSQMPPPSQGGNLY 1775
            ::...:..:.|..:..|.|        .||.....|..:.:.|.||    ::|...|.|....|.
Human  1713 KKNANEKGRSQTSKLPPRFAKKQATGIQQAQSSASVPPLASAPLPP----STSASVPASTSAPLP 1773

  Fly  1776 APFHSLDHSSRSP----AYSAAAAAHSYPNPYAAAAAAAAAAAAGGGPFNVNVNAYAMQTPHGGS 1836
            |....:..|:.:|    ..:...|:.|.|.| |:..|..:|:|:.......:.:|.|:.:   .|
Human  1774 ATLTPVPASTSAPVPASTLAPVLASTSAPVP-ASPLAPVSASASVSASVPASTSAAAITS---SS 1834

  Fly  1837 LPPTAPTPDMYSNLSSQFRLGGGPGPGPGPFGQPSSQQLSNPSNHAAVAIISSSSNSMMSSGAAK 1901
            .|.:||.|                        .|....:|.|   |:|.|::|:|..:::|..|.
Human  1835 APASAPAP------------------------TPILASVSTP---ASVTILASASIPILASALAS 1872

  Fly  1902 ---------------PPQSQQTIGAIGSKSA-----GSGGGPGPGPGPYATTQTYMNLYAAPPPQ 1946
                           |..:..||.|....::     .|...|.|.|.|          .:||.|.
Human  1873 TSAPTPAPAASSPAAPVITAPTIPASAPTASVPLAPASASAPAPAPTP----------VSAPNPA 1927

  Fly  1947 HPGQGGPPPGAHQ-----LQSNSFYSNSAPGG--------PSGPQFY-GGPPPQGNGGAQSYGLA 1997
            .|.........|:     ||:.|..|...|..        |:|..:. .|...|   ..||:|..
Human  1928 PPAPAQTQAQTHKPVQNPLQTTSQSSKQPPPSIRLPSAQTPNGTDYVASGKSIQ---TPQSHGTL 1989

  Fly  1998 TAAGMYGGHQGGPP----------GSNGPPGPPQSQHTMGTFNTPFMNSQLLTAASINQYRGGPT 2052
            ||.  ...::..||          |...||.||    ::..:|.|.  :...:|.|....:.|..
Human  1990 TAE--LWDNKVAPPAVLNDISKKLGPISPPQPP----SVSAWNKPL--TSFGSAPSSEGAKNGQE 2046

  Fly  2053 P-----------GAAYLKGNQGQTHMQDSMGRQLKSPLSADMSLGLAKQVQSQP----------- 2095
            .           ||....||:.:.       ..:.|..|||......:|.|.||
Human  2047 SGLEIGTDTIQFGAPASNGNENEV-------VPVLSEKSADKIPEPKEQRQKQPRAGPIKAQKLP 2104

  Fly  2096 --SPPHHKNY--GAWDLQNQVLQQQQQQSQQQQQQQQRQVGGGNGPSMNALGGRGSGAVGSGSGN 2156
              ||..:|.:  |....:..:..::.:.:||.:.:.|.:.......|.:.:..:.:.||...|
Human  2105 DLSPVENKEHKPGPIGKERSLKNRKVKDAQQVEPEGQEKPSPATVRSTDPVTTKETKAVSEMS-- 2167

  Fly  2157 GGGGGGGAGGSQVG-------GNGGGNGVGSVGQSGGGGQGRYPTP------------------- 2195
                      :::|       ...|.|...||..        |.||
Human  2168 ----------TEIGTMISVSSAEYGTNAKESVTD--------YTTPSSSLPNTVATNNTKMEDTL 2214

  Fly  2196 ---IQRPNNYPQHPQQQQQQQQQQQQQ--------REQAAAAAVAAQRAQNMRQ----VTGA--- 2242
               :..||..|. |:::..||......        ..:..:|..|.:.:.|:|:    ||..
Human  2215 VNNVPLPNTLPL-PKRETIQQSSSLTSVPPTTFSLTFKMESARKAWENSPNVREKGSPVTSTAPP 2278

  Fly  2243 -GGGVAGSAGGGGS------------QTPVGPAGGNGGPGGAG 2272
             ..||:.||.|..:            |.||..........|||
Human  2279 IATGVSSSASGPSTANYNSFSSASMPQIPVASVTPTASLSGAG 2321

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nocte	NP_001245614.1	BAT2_N	1..155	CDD:284431	41/155 (26%)
PRRC2C	XP_005245072.1	BAT2_N	1..162	CDD:284431	62/332 (19%)
		Med15	2258..>2642	CDD:255446	16/64 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4817
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	209	1.000	Inparanoid score	I3685
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001844
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950