DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nocte and Prrc2b

DIOPT Version :9

Sequence 1:	NP_001245614.1	Gene:	nocte / 31976	FlyBaseID:	FBgn0261710	Length:	2309	Species:	Drosophila melanogaster
Sequence 2:	XP_006498011.1	Gene:	Prrc2b / 227723	MGIID:	1923304	Length:	2231	Species:	Mus musculus

Alignment Length:	2754	Identity:	562/2754 - (20%)
Similarity:	849/2754 - (30%)	Gaps:	1048/2754 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LGGSRGERNAKPKFTALDINRMYKNSRGESSEPSAQKNQVPRKHGMQILGKVPSARR--PPANLP 66
            ||.....::.|.|::.|.:...||.    .|..:.:.:.:|| ||:|.||||.:|||  ||||||
Mouse     5 LGQITQGKDGKSKYSTLSLFDKYKG----RSVGAVRSSVIPR-HGLQSLGKVATARRMPPPANLP 64

  Fly    67 SLKAETHTSSNNNLLVSVEGATSGGAGAGGAAGSGAAGTNTSHNNTTAHSGSSGTSGGAGSGGGG 131
            |||:|...:..|.::|..:                  ||..::........||..
Mouse    65 SLKSENKGNDPNIVIVPKD------------------GTGWANKQDQQDPKSSSV---------- 101

  Fly   132 TASSSAGGHLSQQLTHSQHQHNNNVALGPNAGKFVNSNNGSSNNNAGSSGSGNKNFKLINNSVGS 196
            |||         |...||.|        |...|.|:                  |.:....|:..
Mouse   102 TAS---------QPPESQPQ--------PGLQKSVS------------------NLQKPTQSISQ 131

  Fly   197 SGGGGQGGSGGGGSSGVGGGSGSGSGGHSVNSPKTWSAIT---TGHERGSGGQNYGRQQQQVVPH 258
            .           .::.|.||            ||:|:.::   .|||.|..|.:      :::..
Mouse   132 E-----------NTNSVPGG------------PKSWAQLSGKPVGHEGGLRGSS------RLLSF 167

  Fly   259 YQSPQFQYEFPTLDGTVGSGAGGGSGAGVGSGSGAGKSHYQNQVHHAGHQNHHQHQQHHQQHQQH 323
              ||:   |||||     ..|||...||...|:
Mouse   168 --SPE---EFPTL-----KAAGGQDKAGKEKGA-------------------------------- 190

  Fly   324 HHQQQQHHRDYHHGHGRQYGHHSHRDYRDGSDDVGGGSADLGELSLRPQNDTAAWLQQQEKAAKV 388
                    .|..:|.|.                           ||||||.| :|.:
Mouse   191 --------LDLSYGPGP---------------------------SLRPQNVT-SWRE-------- 211

  Fly   389 AAAAAADQGLNLQGPGHHQMGGNGGAGGGSGGAVPLPILSLMPSFMRSGAPMPASGATAASILA- 452
                                       ||....:....||..|:.:.|   ..||||..|..||
Mouse   212 ---------------------------GGGRNIISAASLSASPTELGS---RNASGADGAPSLAC 246

  Fly   453 -GGSLDTSALPNAPYQNGILGARSASPAVVGSGSFRAATAIPKRPPT------------SSSPPQ 504
             ..|.:.|..|..|       :|..:...:|.|         .:|||            .||..|
Mouse   247 TSDSKEPSLRPAQP-------SRRGASQFMGHG---------YQPPTYHDMLPAFMCSPQSSENQ 295

  Fly   505 SGLGIGGSPTP--------PQSQQQANGGAGGAGRKDKDYVVEPEVAQMQRP------------I 549
            :.:.....|.|        |..|.|.|         |:|....|.||:..||            |
Mouse   296 TTVERSSFPLPQLRLEPRVPFRQFQMN---------DQDGKERPGVARPVRPLRQLVERAPRPTI 351

  Fly   550 IREEDLERLNAI--AKDDSWT-KQDDIDFTKKLAFSDDESTPEE---HQGQGKQHS----SAQLQ 604
            |..|:|:.|:.:  ..||.|. ..:::|:::||.|||||.  ||   ..|:.|.::    ..:..
Mouse   352 INAENLKGLDDLDTDADDGWAGLHEEVDYSEKLKFSDDED--EEDVVKDGRSKWNNWDPRRQRAL 414

  Fly   605 AQGSSSSTDQRKL--------------------------SASTTSWQRGKESTDRDQPSEGIQDQ 643
            :..|:.|||.::.                          |....||..|   .|..:|:.|...:
Mouse   415 SLSSADSTDAKRTQEEGKDWSGTAGGSRVIRKVPEPQPPSRKLHSWASG---PDYQKPTMGSMFR 476

  Fly   644 QQQLQQQQQQQEVRQQNGHRGSSGNVGAPVAGGIALDASVYERVKQRKEEEERREMERKQAA-AK 707
            |...:.::.:...||:......|..|               ||.::|:||||||..|.:.|| |.
Mouse   477 QHSAEDKEDKPPPRQKFIQSEMSEAV---------------ERARKRREEEERRAREERLAACAA 526

  Fly   708 KLQELEMKMNSKKAAAAALAGAEGGVSSASVPLSNEVPPTSAPLGNASEDEGGGQGGGGG----- 767
            ||::|:.|....:.|           :....|:..|| |.|..:...|..|.|.....|.
Mouse   527 KLKQLDQKCRQAQKA-----------NETPKPVEKEV-PRSPGIEKVSPPENGPVVRKGSPEFPV 579

  Fly   768 -------LNRRPRGSISSLGSGVTPTGGAGGGGGGVSSSSS------AGGDYGQKNFLTHFQSNL 819
                   |...|         ..:||..........|||||      ..|...|:  .:.:|.:|
Mouse   580 QEAPTMFLEETP---------ATSPTVAQSNSSSSSSSSSSIEEEVRESGSPAQE--FSKYQKSL 633

  Fly   820 PPRFQRQQQQQQQQL-------------------------------------------------- 834
            ||||||||||||||.
Mouse   634 PPRFQRQQQQQQQQQQQQQQQEQLYKMQHWQPVYPPPSHPQRTFYPHHPQMLGFDPRWMMMPSYM 698

  Fly   835 -PRLEKSASASSAFDSNSRYLQKGGV--------SGGGGGVSG---------------------- 868
             ||:..:.:....:.|   .|...|:        |..|.|...
Mouse   699 DPRITPTRTPVDFYPS---ALHPSGLMKPMMPQESLSGTGCRSEDQNCVPSLQERKVTALDPAPV 760

  Fly   869 ----GAQANAGQGRSI----SGGYVQRGASVGGSSGYGRNRHDSSSAREDQDLDQQRFTRGQDYR 925
                |..|...:|.|:    |...:..|..|.....|..:..........:||.::   ||:::
Mouse   761 WSPEGYMALQNKGYSLPHPKSADTLAMGMHVRNERSYCASPGRPGGISAQRDLFEE---RGEEF- 821

  Fly   926 QAQALPRSISENSHRKTSVSSAGDDVL-------------GG-----SCSSW-AEQTDAEQKVHH 971
             ..|..:....:.....|....|.::|             ||     .||.. .:...||:|..:
Mouse   822 -LSAFDKKAQADFDSCISSQRIGQELLFPPQENVQEVGAPGGCTPNLRCSPLEPDFVPAEKKPEY 885

  Fly   972 RHREESFSSSH---SHDSAVQIKILQRPARQPSLS----EESSTQQKQLPASP------------ 1017
                .|:...|   :.|:|..:: |:.|.::||..    |:..:.:||....|
Mouse   886 ----GSWDVGHQPKAADTANGVE-LEAPRQEPSFHVSSWEKEGSPKKQPNPEPEWTPEPRSSSGQ 945

  Fly  1018 -QQQ--KTLTTDPMPTQILR--------RSVDIDKSG-----DERAEDK---------------- 1050
             |:|  :|..:.|:...:|:        ::::..:.|     .:||.:|
Mouse   946 HQEQPGRTRRSGPIKKPVLKALKVEEKEKALERGRQGLREESSQRAPEKEPVGRAEEDEENNPAL 1010

  Fly  1051 ----SALESDDKAKS-------AGKVEEDKSGNKRVSPRSG--------------------AACG 1084
                ||||  |||.|       |.|::||:..:|....|..                    .|.|
Mouse  1011 ANASSALE--DKAASRAGFAHEASKLDEDEKADKTWESRPSREASDIPPTKRNNWIFIDEEQAFG 1073

  Fly  1085 GRG-----GRGY----------AGSS-----GGSSVGSGSSY-RGQRNASDWGSSRGSG------ 1122
            |||     |||:          ||||     |...:||...| .|||      |:||.|
Mouse  1074 GRGQARSRGRGFREFTFRGGRPAGSSTSGLCGTGVLGSRGMYSSGQR------SNRGRGLRDFPP 1132

  Fly  1123 -----GAGGRRYYGS-----GGEQ-----------SEHSE-----DVDE----------ECYSSG 1151
                 .|..||...|     |.|.           ||||.     :.||          ..|:..
Mouse  1133 PEDCPRAKPRRRIASETHSEGSEYEELPKRRRQRGSEHSHEGMLTERDEGALKDSWRSNRTYTED 1197

  Fly  1152 GGGAARRS--PKESGNGAPN--SGASANKAGFSPRGEPSRRGRGGLSSGG--GASASCYRRQPVG 1210
            .||...||  .:..|...|.  |..|..:..|..:..|..:.|...||..  |:|..|..|:  |
Mouse  1198 QGGIDTRSRGSRTCGRALPPRLSNCSYGRRTFVAKEPPHWQSRSPGSSWQEYGSSDPCGPRR--G 1260

  Fly  1211 TGSAGGSGSGGSGRSYGRLGYEEYGKQQRTSESETDLDKTKQNQLALSAGLHKPSKDDKDLPALG 1275
            |.......|.....::|...:|:...:.:.|..:.|.....:|.........:|.:.||. |...
Mouse  1261 TDRDYIPDSYRQSDTFGSRLFEDSRTEDKRSFFQDDHGADSENAENRPFRRRRPPRQDKP-PRFR 1324

  Fly  1276 --GEEKDKTAALAPAHNTALLAKDELQKDAAGRLPLPPG-LAAPGSAVGSVTATSSSVVVPGAAD 1337
              .:|::......|...:.|||     ....||..|.|| .:.||
Mouse  1325 RLRQERESLGLWGPEEESHLLA-----SQWPGRSKLCPGDKSGPG-------------------- 1364

  Fly  1338 KKKIESCAVVGGEKVTGSKLPAIGEKTSLGAVGSGPSTSLLLDAGAPVNTIIFENSTY-KQQAAA 1401
                            |.:.|.:..:.|.........|:             .|:|.: :::...
Mouse  1365 ----------------GHRSPELSYQNSSDHANEEWETA-------------SESSDFSERRERR 1400

  Fly  1402 ASVVTKP-----GTLSVSSSGATMTVDSLSSALSQMSFGGKATAAGSGDDSQDMKL--GFSFGDD 1459
            ..:|.:|     |.||.||.|.       ...|::.||..:...|    |.|..||  | .||:.
Mouse  1401 EGLVAEPEAQGDGGLSGSSLGE-------KKELAKRSFSSQRPLA----DRQSRKLEPG-GFGEK 1453

  Fly  1460 PTTPLKVVDNIDKTASQQQQQQQQQHSQQQQQQQQQQNNSTADLNMKIASVKKVWESATP----- 1519
            |..|                    ...:...:.:.||:.:.       ..||:..:.|.|
Mouse  1454 PVRP--------------------GGGEPSPRCESQQSGTP-------LKVKRSPDEALPGGLGS 1491

  Fly  1520 ------------MSDGPSPAQVQQQQQQQPQQQQQSQVQVAAQQQQQQVVGPQQAGDDGSGHMSA 1572
                        .||||          :.|.::.:.:|.:..|:..:|....:|. |.|.|:
Mouse  1492 HSPYALERTTHASSDGP----------ETPSKKSEREVSLPTQRASEQEEARKQF-DLGYGN--- 1542

  Fly  1573 ASFVAAVAASQHQQQHQQMPHYAVSAVHMQSHHHQQQQQQQQAAVAAAQAQHHQQQQAQAHHQHH 1637
             :.:...|:|..::..       .|:|..:.......::|::   ...:.:..::|.||...:..
Mouse  1543 -ALIDNCASSPGEENE-------ASSVVGEGFIEVLTKKQRR---LLEEERRKKEQAAQVPVKGR 1596

  Fly  1638 ALSS---------------------PG---------------PVPGSHGHGYSHG----SPFDAG 1662
            .|||                     ||               ||.|:....:...    |..:.|
Mouse  1597 GLSSRIPPRFAKKQNGLCLEQDVTVPGSSLGTEIWENSSQALPVQGAASDSWRTAVTAFSSTEPG 1661

  Fly  1663 SLEQQFQQE------DYPSPQQQQQAHQKTKQ-----LQQQQHLGMSPPPSQQQQQQHSQQ-QQQ 1715
            :.||.|:..      |..:..::..|....:.     |:.::..|  |..::.:...|..| |:|
Mouse  1662 TSEQGFKSSQGDSGVDLSAESRESSATSSQRSSPYGTLKPEEISG--PGLAESKADSHKDQAQKQ 1724

  Fly  1716 AQHQQQQQQAHQQQQQQQQP-----SFYQASPQFGVGGIPTIPSPP---AVVYNSSQMP-PPSQG 1771
            |:|:..:|.:.|.::.:..|     |........|...:|....||   ..::..|.:| ||.:.
Mouse  1725 AEHKDSEQGSAQSKEHRPGPIGNERSLKNRKGSEGAERLPGAVVPPVNGVEIHVDSVLPVPPIEF 1789

  Fly  1772 GNLYAPFHSLDHSSRSPAYSAAAAAHSYP--NPYAAAAAAAAAAAAGGGPFNVNVNAYAMQTPHG 1834
            |          .|.:...:|....:.|.|  ||.|......|:.|.......:....:.||...|
Mouse  1790 G----------VSPKDSDFSLPPGSVSGPVGNPVAKLQDVLASNAGLTQSIPILRRDHHMQRAIG 1844

  Fly  1835 GSLPPTAPTPDMYSNLSSQFRLGGGPGPGPGPFGQPSSQQLSNPSNHAAVAIISSSSNSMMSSGA 1899
            .| |.:.||.|:...:.|..:...         ..||..:.|:|..               :...
Mouse  1845 LS-PMSFPTADLTLKMESARKAWE---------NSPSLPEQSSPGG---------------AGSG 1884

  Fly  1900 AKPPQSQQTIGAIGSKSAGSGGGPGPGPGPYATTQTYMNLYAAPPPQHPGQGGPPPGAHQLQSNS 1964
            .:||.|   :||....:..|.||....|.|.|:        .||....||...||   ..|..:.
Mouse  1885 IQPPSS---VGASNGVNYSSFGGVSMPPMPVAS--------VAPSASIPGSHLPP---LYLDGHV 1935

  Fly  1965 FYSNSAPGGPSGPQFYGGPPPQGNGGAQSYGLATAAGMYG-------------GHQGGPPGSNGP 2016
            |.|.        |:......||    .|||..|..|....             |.:||.|.|
Mouse  1936 FASQ--------PRLVPQTIPQ----QQSYQQAATAQQIPISLHTSLQAQAQLGLRGGLPVS--- 1985

  Fly  2017 PGPPQSQHTMGTFNTPFMNSQL-----LTAASINQYRGG--------------------PTPGAA 2056
                |||....:.. || .||:     |:..|.....||                    |..|:.
Mouse  1986 ----QSQEIFSSLQ-PF-RSQVYMHPSLSPPSTMILSGGTALKPPYSAFPGIQPLEMVKPQSGSP 2044

  Fly  2057 Y--LKGNQ--------------GQTHMQDSMGRQLKSPL----SADMSLGLAKQVQSQPS----- 2096
            |  :.|||              |.:.|.||...||..||    |....|.|.:.:|..|.
Mouse  2045 YQPMSGNQALVYEGQLGQAAGLGTSQMLDSQLPQLTMPLPRYGSGQQPLILPQSIQLPPGQSLSV 2109

  Fly  2097 -------PPHHKNYGAWDLQNQVLQQQQQQSQQQ------QQQQQRQVGGGNGPSMNALGGRGSG 2148
                   ||     |:   |..||...::.:..:      ...:|....||:.||..|.  |.|.
Mouse  2110 GAPRRVPPP-----GS---QPPVLNTSRESAPMELKGFHFADSKQNVPTGGSAPSPQAY--RPSS 2164

  Fly  2149 AVGSGSGNGGGGGGGAGGSQVGGNGGGNGVGSVGQSGGGGQGRYPTPIQRPNNYPQHPQQQQQQQ 2213
            |..||.         ..||.|       .:|||       ||.|....:|.:..|.....:.|:.
Mouse  2165 ASPSGK---------PSGSAV-------NMGSV-------QGHYVQQAKRVDEKPGLGTVKLQEA 2206

  Fly  2214 QQQQQQREQAAAAAVAAQRAQNMR 2237
            .....|.::..|....|.:.:..:
Mouse  2207 SSATSQMKRTGAIKPRAVKVEGSK 2230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nocte	NP_001245614.1	BAT2_N	1..155	CDD:284431	43/152 (28%)
Prrc2b	XP_006498011.1	BAT2_N	1..189	CDD:369167	71/290 (24%)
Prrc2b	XP_006498011.1	PHA03247	<1741..2176	CDD:223021	115/523 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4817
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001844
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4263
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930