|
Fly 1 MSTLGGSRGERNAKPKFTALDINRMYKNSRGESSEPSAQKNQVPRKHGMQILGKVPSARR--PPA 63
||...|...:.....|:..|.:...|| |:|.| .||..|..:||:|.||||..:|| |||
Mouse 1 MSEKSGQSTKAKDGKKYATLSLFNTYK---GKSLE--TQKTTVAARHGLQSLGKVGISRRMPPPA 60
Fly 64 NLPSLKAETHTSSNNNLLVSVEGATSGGAGAGGAAGSGAAGTNTSHNNTTAHSGSSGTSGGAGSG 128
||||||||...:..|..:|..:|.
Mouse 61 NLPSLKAENKGNDPNVNIVPKDGT----------------------------------------- 84
Fly 129 GGGTASSSAGGHLSQQLTHSQHQHNNNVALGPNAGKFVNSNNGSSNNNAGSSGSGNKNFKLINNS 193
|..|:| .||:......:.|...|
Mouse 85 ----------GWASKQ---EQHEEEKAPEVSPAQPK----------------------------- 107
Fly 194 VGSSGGGGQGGSGGGGSSGVGGGSGSGSGGHSVNSPKTWSAITTGHERGSGGQNYGRQQQQVVPH 258
.|..:......:||:|:: ...|||..|.|
Mouse 108 -----------------------PGVAAPPEVAPAPKSWAS------NKQGGQGDGIQ------- 136
Fly 259 YQSPQFQYEFPTLDGTVGSGAGGGSGAGVGSGSGAGKSHYQNQVHHAGHQNHHQHQQHHQQHQQH 323
.:.|||.|||:|.. ||.|
Mouse 137 -VNSQFQQEFPSLQA-------------------------------AGDQ--------------- 154
Fly 324 HHQQQQHHRDYHHGHGRQYGHHSHRDYRDGSDDVGGGSADLGELSLRPQNDTAAWLQQQE--KAA 386
.::::...|.::|.|......:...:|||....|..|:|..|..|.....||...:|.: |..
Mouse 155 -EKKEKEANDENYGPGPSLRPPNVACWRDGGKSAGSPSSDQDEKQLGQDESTAITSEQNDILKVV 218
Fly 387 KVAAAAAADQG-LNLQGPGHHQMGGNGGAGGGSGGAVPLPILSLMPSFMRSGAPMPASGATAASI 450
:...|....|. ||.|.| |:.....::||.:|....|
Mouse 219 EKRIACGPPQAKLNGQQP-----------------ALASQYRAMMPPYMFQQYP----------- 255
Fly 451 LAGGSLDTSALPNAPYQNGILGARSASPAVVGSGSFRAATAIPKRPPTSSSPPQSGLGIGGSPTP 515
|.|.|.:.|...| ||:.|...:|..|.| |
Mouse 256 -----------------------RMAYPPLHGPMRF---------PPSLSEANKSLRGRG----P 284
Fly 516 PQSQQQANGGAGGAGRKDKDYVVEPEVAQMQRPII------REED-LERLNAIAKDDSWT-KQDD 572
|.| :..||| ||.| :|.| .:.|:|.| |:.|. .|.:
Mouse 285 PPS-----------------WASEPE-----RPSILSASELKELDKFDNLDAEA-DEGWAGAQME 326
Fly 573 IDFTKKLAFSDDESTPEEHQGQGKQHSSAQLQAQGSSSSTDQRK---LSASTTS----------- 623
:|:|::|.|||| :|......:.||::.|...:..||:.|| .::||.|
Mouse 327 VDYTEQLNFSDD----DEQGSTSPKESSSEDQTAKTPESTENRKEVDEASSTKSSSQIPAQPPVT 387
Fly 624 ---WQRGKESTDRDQPSEGIQDQQQQLQQQQQQQEVRQQNGHRG--------------------S 665
:.:|........||..:....:.|.||......||..|.:| .
Mouse 388 KSPYGKGPPFNQERGPSSHLPPPPKLLAQQHPPPPDRQIPGRQGPFPSKPPVPDNDEIWKQRRKQ 452
Fly 666 SGNVGAPVAGGIALDASVYERVKQRKEEEERR-EMERKQAAAKKLQELEMKM------------- 716
...:.|.| ||.::|:|||||| |.:||.|.|:||::|:.|:
Mouse 453 QSEISAAV-----------ERARKRREEEERRMEEQRKAACAEKLKQLDEKLGIIEKQPSPEELR 506
Fly 717 -------------------------------------------NSKKAAAAALAGAEGGVSSASV 738
..|:.....|...|........
Mouse 507 EREREKERERELEKEKERELEKEQEKQREMERARQQEKELEQQREKEQELQRLREQEKEGEPKEQ 571
Fly 739 PLSNEVPPTSAPLGNASEDEGGGQGGGGGLNRRPRGSISSLGSG-----VTPTGGAGGGGGGVSS 798
....:|.|....:..|:|: |.......:......:...|. .|.. |..
Mouse 572 EKEEKVEPQEPVVEPATEN----QESENNCKKEEEPIFTRQDSNRSEKETTQV---------VQE 623
Fly 799 SSSAGGDYGQKNFLTHFQSNLPPRFQR-----------QQQQQQQQ--LPRLEKSAS-------- 842
:....|...:..:...||.:||||||| |||||||| ||:...|..
Mouse 624 AEPESGAQPRPGYFKQFQKSLPPRFQRQQEQMKQQQWQQQQQQQQQGVLPQTVPSQPSNGSVPPP 688
Fly 843 ----------------ASSAFDSN----SRYLQKGGVSGGGG----GVSGGA----------QAN 873
||..||.. ..|:....:||... .:..|. |..
Mouse 689 PHRPLYQPMQPHPQHLASMGFDPRWLMMQSYMDPRMISGRPAMDIPPIHPGMIPPKPLIRRDQME 753
Fly 874 AGQGRSISGGYVQRGA-----------SVGGSSGY---------GRNRHDSSSAREDQDLDQQRF 918
.....|.|..::.|.| .:.||..| .::..::..||.:..:|.:..
Mouse 754 GSPNSSESFEHIARSARDHGISLSEPRMMWGSDPYHAEPQQAATPKSAEETGDARPETAMDHEHM 818
Fly 919 TRGQDYRQAQA--------------------LPRSISE--NSHRKTSVSSAGDDVLGGSC--SSW 959
|.......:|. |.||:.: ..|..|:..||..||:.... :|.
Mouse 819 TAAYPVEHSQLETHSKTDVARDSTETEEQKFLSRSLEDVKPRHVDTNTQSACFDVIDQKSLPTSA 883
Fly 960 AEQTDAEQKVHHRHREESFSSSHS-------HDSAVQI-KILQR--------------------- 995
.|:..|.:....|.|..|..|:|: ::.:|.| |::.|
Mouse 884 EERISALESQPARKRSVSHGSNHAQNAEEQRNEPSVSIPKVINRCMDSKETVEKPEEKPRKDGFL 948
Fly 996 -----------------------------------------PARQPSLSE--ESSTQQKQ----- 1012
|.::|.|.: |...|:|:
Mouse 949 RSSEGPKPEKVYKSKSETRWGPRPSSNRREEGNDRPVRRSGPIKKPVLRDMKEEREQRKEKEGEK 1013
Fly 1013 --------------------------LPASPQQQKTLTTDPMPTQILRRSVDIDKSGDERAEDKS 1051
.||.||.|..::....|......|.:......:.::|:.
Mouse 1014 LEKVTEKVVKAEKPEKKDLPLPLPPPAPAQPQPQPLVSPPVQPEPEKPPSTETSTLTQKPSQDEK 1078
Fly 1052 ALES-------------DDKAKSAGKVEEDKS---------GNKRVSPRSGAACGGRGG------ 1088
.||. :.::.:|..|:|:|. |.:|..|.|..|......
Mouse 1079 PLEPVGSVQVEPVVKTVNQQSVAAPTVKEEKPPEKVINKDVGIERSRPDSRLAVKKDSSLPTRTY 1143
Fly 1089 ------------RGYAGSSGGSSVGSGSSYRGQRNASDWGSSRGSGGAGGRRYY----------- 1130
:||.|...|.....|.|||| .:| .||.||.|..|.|
Mouse 1144 WKEARDRDWFPDQGYRGRGRGEYYSRGRSYRG-----SYG-GRGRGGRGHTREYPQYRDNKPRTE 1202
Fly 1131 --GSGG-EQSEHSE----------------------DVDEECYSSGG-------GGAARRS--PK 1161
.||. .|.|.|| |.|.|.:.|.. |...:|. |:
Mouse 1203 HVPSGPLRQREESETRSESSDFEVVPKRRRQRGSETDTDSEVHESASDKDSVSKGKLPKREERPE 1267
Fly 1162 ESGNGAPNSG---------------------ASANKAGFSPRGEPSRRGRGGLSSGGGASASCYR 1205
......|.|. ...:|.||.|:|||:||||||....||
Mouse 1268 NKKPVKPQSSFKPENHVRIDNRPLEKPYIREEDKSKPGFLPKGEPTRRGRGGTFRRGG------- 1325
Fly 1206 RQPVGTGSAGGSGSGGSGRSYGRLGYEEYGKQQRTSESETDLDKTKQNQLALSAGLHKPSKDDKD 1270
|.|.|..|... :..|..|.: .|..|.::| .|..:|
Mouse 1326 RDPGGRPSRPA--------TLRRPAYRD--NQWNTRQAE------------------PPKPED-- 1360
Fly 1271 LPALGGEEKDKTAALAPAHNTALLAKDELQKDAAGRLP------LPPGLAAPGSAVGSVTATSSS 1329
||...:.....|........|.|.:.|.|...| .||....|
Mouse 1361 -----GEPPRRHEQFMPIPADKRPPKFERKFDPARERPRRQRPTRPPRQDKP------------- 1407
Fly 1330 VVVPGAADKKKIESCAVVGGEKVTGSKLPAIGEKTSLGAVGSGPSTSLLLDAGAPVNTIIFENST 1394
|.....::.|:.: ||| .:|:.:....|.::.|
Mouse 1408 ---PRFRRLREREAAS-----------------KTS----------EVLVPSNGTANNVVQE--- 1439
Fly 1395 YKQQAAAASVVTKPGTLSVSSSGATMTVDSLSSALSQMSFGGKATAAGSGDDSQDMKLGFSFGDD 1459
.|..|..:| |.|
Mouse 1440 ---------PVNPPADIS----------------------GNK---------------------- 1451
Fly 1460 PTTPLKVVDNIDKTASQQQQQQQQQHSQQQQQQQQQQNNSTADLNMKIASVKKVWESATP----- 1519
|| |..::.:|.|..::.:..|:.....::::.:...:.:....:|.|..||..|
Mouse 1452 --TP----DLSNQNSSDQANEEWETASESSDFNERRERDEKKNADKSSQAVVKAGESVLPPKREI 1510
Fly 1520 -----MSDGPSPAQVQQQQQQQPQQQQQSQVQVAAQQQQQQVVGPQQAGDDGSGHMSAASFVAAV 1579
.|..|. |.:|.::......:|....:..:.:::...|.:.|..|.....|:....|.
Mouse 1511 AKRSFSSQRPG---VDRQNRRGNNGPPKSGRNFSGPRNERRNGPPSKGGKRGPFDDQASGTAGAD 1572
Fly 1580 AASQHQQQHQQ-MPHYAVSAVHMQSHHHQQQQQQQQAAVAAAQAQHHQQQQAQAHHQHHALSSPG 1643
..|.:...||: :|:.| .|:.:..||.:.:.. :.||
Mouse 1573 PVSGNSAHHQEGVPNGA---------------GQKNSKDAAGKKRED--------------TKPG 1608
Fly 1644 PVPGSHGHGYSHGSPFDAGSLEQQFQQEDYPSPQQQQQAHQKTKQLQQQQHL---GMSPPPSQQQ 1705
| ..|.:......||...:|.|........:.|.....|.:| |.:...|::|
Mouse 1609 P-----------KKPKEKVDALSQFDLNNYASVVIIDDHPEVTVIEDPQSNLNDDGFTEVVSKKQ 1662
Fly 1706 QQQHSQQQQQAQHQQQQQ--------QAHQQQQQQQQPSFYQASPQFGVGGIPTIPSPPAVVYNS 1762
|::...::::.:.:|..| :..:.|..:..|.| |..| ..|...|.:|| |
Mouse 1663 QKRLQDEERRKKEEQVVQVWSKKNIGEKGRSQTSKLPPRF--AKKQ--ATGTQQIQAPP-----S 1718
Fly 1763 SQMPPPSQGGNLYAPFHSLDHSSRSPAYSAAAAAHSYPNPYAAAAAAAAAAAAGGGPFNVNVNAY 1827
:.:|..|....|.|| ||||..|.|.|....|:|.|.... ..|..|..:..
Mouse 1719 APVPVSSSAPGLTAP--------------AAAAPASTPAPVPILASATALVPV-STPAPVLTSCP 1768
Fly 1828 AMQTPHGGSLP-PTAPTPDMYSNLSSQFRLGGGPG-PGPGPFGQPSSQQLSNPSNHAAVAIISSS 1890
| ..|...|.| |.:.:..:.::.||| |. |.|.|. |::.|...:|.|::|:
Mouse 1769 A-PVPTSASAPVPASTSSPVTASSSSQ------PSVPAPTPV-------LASASTTVSVPILTSA 1819
Fly 1891 SNSMMSSGAAKPPQSQQT--IGAIGSKSAGSGGGPGPG----------------PGPYAT----- 1932
|..:::|..|....|..| :.|....|..:...|... |.|.:|
Mouse 1820 SIPILASALAPATVSSPTPVVSATAVPSISTPAVPASAPTASVPLAPASAASTVPPPASTVQTQT 1884
Fly 1933 -TQTYMNLYAAPPPQHPGQGGPPPGAHQLQS--NSFYSNSAPGGPSGPQFYGGPPPQGNGGAQSY 1994
|||:..:.:..||..|....|||.. :|.| .|..::....|.|.|. :||:
Mouse 1885 QTQTHKPVQSPLPPSAPSSKQPPPSI-RLPSAQTSNGTDFVAAGKSMPT------------SQSH 1936
Fly 1995 GLATAAGMYGGHQGGPPGSN------GPPGPPQSQHTMGTFNTPFMNSQLLTAASINQYRGGPTP 2053
|..||. ::......|...| ||..|||.. ::..:|.|. :...:|.|....|.|...
Mouse 1937 GSLTAE-LWDSKVAAPAVLNDISKKLGPISPPQPP-SVSAWNKPL--TSFGSATSSEGTRNGQES 1997
Fly 2054 -----------GAAYLKGNQGQT----------HMQDSMGRQLKSPLSADM------SLGLAKQV 2091
||....||:.:. .:.:...::.|.|.:..: .|.|.:..
Mouse 1998 GVEIGIDTIQFGAPASNGNENEVVPVLSEKATDKVPEPKEQRQKQPRAGPIKAQKLPDLSLVENK 2062
Fly 2092 QSQPSPPHHKNYGAWDLQNQVLQQQQQQSQQQQQQQQRQVGGGNGPSMNALGGRGSGAVGSGSGN 2156
:.:|.|...:. .|:|:.::..||...:.|::....|.....|.. .:.:.||...|
Mouse 2063 EHKPGPIGKER----SLKNRKVKDAQQVEPEGQEKPSPAVVRSTDPET----AKETKAVSEMS-- 2117
Fly 2157 GGGGGGGAGGSQVGGNGGGNGVGSVGQSGGGGQGR-----YPTP--------------------- 2195
:::| .:.||..:..|...: |.||
Mouse 2118 ----------AEIG------AMISVSSAEYGSDAKESVTDYTTPSSSLPNTVATNNAKMEDTLVN 2166
Fly 2196 -IQRPNNYPQHPQQQQQQQQQQQQQ--------REQAAAAAVAAQRAQNMRQ----VTGAG---- 2243
:..||..|. |:::..||...... ..:..:|..|.:.:.|:|: ||...
Mouse 2167 NVPLPNTLPL-PKRETIQQSSSLTSVPPTTFSLTFKMESARKAWENSPNLREKGSPVTSTAPPIV 2230
Fly 2244 GGVAGSAGGGGS------------QTPVGPAGGNGGPGGAG 2272
.||:.||.|..: |.||..........|||
Mouse 2231 SGVSSSASGPSTANYSSFSSASMPQIPVASVTPTASLSGAG 2271
| 
