DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nocte and F52G3.1

DIOPT Version :9

Sequence 1:	NP_001245614.1	Gene:	nocte / 31976	FlyBaseID:	FBgn0261710	Length:	2309	Species:	Drosophila melanogaster
Sequence 2:	NP_510744.1	Gene:	F52G3.1 / 181741	WormBaseID:	WBGene00018710	Length:	1172	Species:	Caenorhabditis elegans

Alignment Length:	1466	Identity:	272/1466 - (18%)
Similarity:	427/1466 - (29%)	Gaps:	494/1466 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   931 PRSISEN---SHRKTSVSSAGDDVLGGSCSSWAEQTDAEQKVHHRHREESFSSSHSHDSAVQIKI 992
            |:::|.|   |.|..:....|:|.......|..:                        :|..::.
Worm    14 PKAVSVNNLFSGRNLAPGQRGNDPSRNGMQSVGK------------------------AANVVRR 54

  Fly   993 LQRPARQPSLSEESSTQQKQLPASPQ----------------QQKTLTTD---------PMPTQI 1032
            :..||..|||..|::.|....|..||                ..:|.|..         |.|...
Worm    55 MPPPASLPSLRAENNGQDPTTPVVPQGGTGWSKSDNPNGAAEPPQTPTNQAPAVPPPPPPQPAND 119

  Fly  1033 LRRSVDIDKSGDERAEDKSALESDDKAKSAGKVEEDKSGNKRVSPRSGAA---CGGRGGRGYAGS 1094
            ||.|..:..:.:::|.:..|.|....|..|.  :.|||.||.....|..|   .....|..:.|.
Worm   120 LRPSWLVAANAEQQANNSQAREFPSLAPPAN--DSDKSNNKWDITSSSLAEKLTDMPNGEQFEGG 182

  Fly  1095 SG----GSSVGSGSSYRGQRNASDWGSSRGSGGAGGRRYYGSGGEQSEHSEDVDEECYSSGGGGA 1155
            ..    |.:..:.|:.....||.       ||....:....:.|..:::::..|:|.:.|..
Worm   183 VPIRFLGPNTTAASTAESAFNAK-------SGSQKPQPPTTANGSSTKYNKISDDEGFDSQD--- 237

  Fly  1156 ARRSPKESGNGAPNSGASANKAGFSPRGEPSRRGRGGLSSGGGASASCYRRQPVGTGSAGGSGSG 1220
                        .:...|..:.|:||.|.||:             ..||         .....:.
Worm   238 ------------RDRNYSTEEGGWSPNGSPSQ-------------TVCY---------GPDKDTE 268

  Fly  1221 GSGRSYGRLGYEEYGKQQRTSESETDLDKTKQNQLALSAGLHKPSKDDK--------DLPAL--- 1274
            ...|||.|....::    ||||..  :.|....||.|     :...||:        |.|:|
Worm   269 NEYRSYLRNDLPQF----RTSEIR--ILKRATEQLLL-----QDISDDEDEVQMTRLDKPSLCIV 322

  Fly  1275 --GGEEKDKTAALAPAHNTALLAK-------------DELQKDAAG----------RLPLPPGLA 1314
              |||.|..|.|......:...||             .:|:|:...          :..:||...
Worm   323 KRGGEIKPPTVAKQDREKSVQEAKTSHPPAPVKPPKEKKLRKEGKSSKKEKDVKEKKQTVPPPNP 387

  Fly  1315 APGSAVGSVT---------ATSSSVVVPGAADKKKIESCAVVGGEKVTGSKLPAIGEKTSLGAVG 1370
            .|..|...:.         .|.:..|:|....::.:.:......|.:...|..::..:....|:.
Worm   388 GPAPAPAPIAIDTPPASEKTTPAEEVLPAPPPQENVWAKRKEERESLEREKEKSLMPRVMQQAIE 452

  Fly  1371 SGPSTSLLLDAGA-PVNTIIFENSTYKQQAAAASVVTKPGTLSVSSSGATMTVDSLSSALSQMSF 1434
            .  ...::.||.. .||......|:..:...||....|..|    |:.....::|.|||..:|:.
Worm   453 Q--HFPMVHDAATIKVNKESTRKSSDTEFTRAAIRARKQAT----SNDVRRLMNSESSAKMKMNR 511

  Fly  1435 GGKATAAGS-----GDDSQDMKLGFS---------------FGDDPTTPLKVV--DNIDKTASQQ 1477
            .|.....||     |..:.....|:.               |.::.....|..  .|:....|..
Worm   512 MGNQENYGSEEKVNGKQNGGFTNGYKAAQNGALRNNQTNGRFAENSHRERKDSHRSNVSSHHSDD 576

  Fly  1478 QQQQQQQHSQQQQQQQQQQNNSTADLNMKIASVKKV--WESATPMSDGPSPAQVQQQQ-----QQ 1535
            .::....||::::.::.::|......|::..|...:  |.......||......::::     ::
Worm   577 AKKHMNGHSKKKETEKLKENGDVKKFNIEDCSNVNIESWADEMENMDGFEEVNSKKKKNKTLAEK 641

  Fly  1536 QPQQQQQSQVQVAAQQQQQQVVGPQQAGDDGSGHMSAASFVAAVAASQHQQQHQQMPHYAVSAVH 1600
            |..||.:||:|...|.|                             ||:|.|.           |
Worm   642 QNVQQSKSQLQNHTQNQ-----------------------------SQNQSQD-----------H 666

  Fly  1601 MQSHHHQQQQQQQQAAVAAAQAQHHQQQQAQAHHQHHALSSPGPVPGSH--GHGYSHGSPFDAGS 1663
            .::...:.:..:|...:...:|...:.....|    :.|.||..|....  ....|:|..|.:..
Worm   667 EKNSKTKPKDPKQGTRLFVPKALRKEADDLPA----NGLLSPQSVETKEKIAAAKSNGDVFKSDE 727

  Fly  1664 LEQQFQQEDYPSPQQQQQAHQKTKQLQQQQHLGMSPP---------------PSQQ------QQQ 1707
            ..:.|.  |..:|:......:.||: .:.||:....|               |..|      ..:
Worm   728 QSKGFW--DSLTPEVSTIPKKMTKK-PEGQHVEFPKPVGKSLDITGYDFTFDPQLQITNPIISDR 789

  Fly  1708 QHSQQQQQAQHQQQQQQAHQQQQQQQQPSFYQASPQFGVGGIPTIPSPPAVVYNSSQMPPPSQGG 1772
            ...||...|::......:|.::....:  ..|:..:.|    |...:..:..||......|:...
Worm   790 VAIQQMLSAENAATDDDSHHRRNVLNE--LRQSIDELG----PVAMAKVSQEYNEVFSCRPNNNN 848

  Fly  1773 NLYAPFHSLDHSSRSPAYSAAAAAHSYPNPYAAAAAAAAAAAAGGGPFNVNVNAYAMQTPHGGSL 1837
            ...||| |..:||..|.::...|...||.
Worm   849 VSLAPF-SNHYSSFQPLFNTGDAPLLYPT------------------------------------ 876

  Fly  1838 PPTAPTPDM-------YSNLSSQFRLGGGPGPGPGPFGQ-PSSQQLSNPSNHAAVAIISSSSNSM 1894
              .||:|.|       :|||..|   .|...|..|..|: |:||..      ||.|::::....:
Worm   877 --AAPSPPMSYLNMMNFSNLKRQ---SGYGAPENGLLGRIPNSQAA------AAAAVVAAQQQRI 930

  Fly  1895 MSSGAA---------KPPQSQQTIGAIGSKSAGS---------GG-------GPGPGPGPY--AT 1932
            .:.|||         .||.:..:.|:.|..:.||         ||       |.|.|..||  .|
Worm   931 WNGGAAHFDINSLAGTPPANYSSNGSYGFFNNGSNANEHRAPFGGLPNGMLNGMGNGQAPYFDRT 995

  Fly  1933 TQTYMNLYAAPPPQHPGQGGPPPGAHQLQSNSFYSNSAP--------GGPSGPQFYGGPPPQGNG 1989
            |....||......|..|.........|.|..| ...|.|        |||..||.....||
Worm   996 TLPPANLAVGSQRQFSGNMNRQQQQQQQQQQS-SGQSHPMNGMGNSNGGPQFPQQNFTQPP---- 1055

  Fly  1990 GAQSYGLATAAGMYGGHQGGPPGSNGPPGPPQSQHTMGTFNTPFMNSQLLTAASINQYRGGPTPG 2054
                                ||....||....|....|.|   |.|:.       |:...|..||
Worm  1056 --------------------PPVMRFPPSNGTSHQDNGPF---FFNNG-------NRAPIGRPPG 1090

  Fly  2055 AAYLKGNQGQTHMQDSMGRQLKSPLSADMSLGLAKQVQSQPSPPHHKNYGAWDLQNQVLQQQQQQ 2119
            .: ..|:..|..|                                     .|...|
Worm  1091 LS-AAGHSAQLDM-------------------------------------IWSNSN--------- 1108

  Fly  2120 SQQQQQQQQRQVGGGNGPSMNALGGRGSGAVGSGSGNGGGGGGGAGGSQVGGNGGGNGVGSVGQS 2184
                                |:..|....:..|.:|..|.|.||.||.|..|
Worm  1109 --------------------NSYFGNAGHSNSSWNGGAGAGAGGVGGVQAAG------------- 1140

  Fly  2185 GGGGQGRYPTPIQRPNNYPQHPQQQQQQQQQQQQQR 2220
                      |: |.|.|    .|:|.:..||...|
Worm  1141 ----------PL-RQNGY----NQRQVRDNQQMNNR 1161

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nocte	NP_001245614.1	BAT2_N	1..155	CDD:284431
F52G3.1	NP_510744.1	BAT2_N	3..>149	CDD:393420	30/158 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4817
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001844
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4263
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930