Protein Alignment RabX2 and RAB7A

DIOPT Version :10

• Sequence 1: NP_572627.1
• Gene: RabX2 / 31971
• FlyBaseID: FBgn0030200
• Length: 195
• Species: Drosophila melanogaster
• Sequence 2: NP_004628.4
• Gene: RAB7A / 7879
• HGNCID: 9788
• Length: 207
• Species: Homo sapiens
• Alignment Length: 202
• Identity: 63/202 - (31%)
• Similarity: 114/202 - (56%)
• Gaps: 24/202 - (11%)

  Fly     7 LFKVLVLGDSGVGKSCLLMRFSDDRFTEKYLRTMGIDVKARSVELVSRVMMLQVWDTSGDKRFNS 71
            |.||::||||||||:.|:.::.:.:|:.:|..|:|.|...:.|.:..|::.:|:|||:|.:||.|
Human     8 LLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQS 72

  Fly    72 LMPSNYRSAHGILLVYDITSSKSFQNIDGWMKEIRRMC----PDKVTVLLVGNKSDDPNHRQVSM 132
            |..:.||.|...:||:|:|:..:|:.:|.|..|.....    |:....:::|||.|..| |||:.
Human    73 LGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLEN-RQVAT 136

  Fly   133 E--QGFNYAHRGALGFEEVSAKSGMNVYDIFSSLA---------MDIYHRYVLHNPISPMPSEQE 186
            :  |.:.|: :..:.:.|.|||..:||...|.::|         :::|:.:       |.|.:.:
Human   137 KRAQAWCYS-KNNIPYFETSAKEAINVEQAFQTIARNALKQETEVELYNEF-------PEPIKLD 193

  Fly   187 EEDAAES 193
            :.|.|::
Human   194 KNDRAKA 200

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RabX2	NP_572627.1	Rab	8..165	CDD:206640	56/162 (35%)
RAB7A	NP_004628.4	Rab7	9..179	CDD:206655	57/171 (33%)
		Switch 1. /evidence=ECO:0000269|PubMed:15933719, ECO:0007744|PDB:1T91, ECO:0007744|PDB:1YHN	28..41		2/12 (17%)
		Switch 2. /evidence=ECO:0000269|PubMed:15933719, ECO:0007744|PDB:1T91, ECO:0007744|PDB:1YHN	67..82		6/14 (43%)