DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RabX2 and RAB43

DIOPT Version :9

Sequence 1:	NP_572627.1	Gene:	RabX2 / 31971	FlyBaseID:	FBgn0030200	Length:	195	Species:	Drosophila melanogaster
Sequence 2:	NP_001191812.1	Gene:	RAB43 / 339122	HGNCID:	19983	Length:	212	Species:	Homo sapiens

Alignment Length:	193	Identity:	69/193 - (35%)
Similarity:	116/193 - (60%)	Gaps:	13/193 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FDYLFKVLVLGDSGVGKSCLLMRFSDDRFTEKYLRTMGIDVKARSVELVSRVMMLQVWDTSGDKR 68
            :|:|||::::||:.|||:|::.||....|:|:...|:|:|...:::|:..:.:.||:|||:|.:|
Human    15 YDFLFKLVLVGDASVGKTCVVQRFKTGAFSERQGSTIGVDFTMKTLEIQGKRVKLQIWDTAGQER 79

  Fly    69 FNSLMPSNYRSAHGILLVYDITSSKSFQNIDGWMKEIRRMCPDKVTVLLVGNKSDDPNHRQVSME 133
            |.::..|.||||:|.:|.||||...||.::..|::::|:.....:..||:|||||....|:||:.
Human    80 FRTITQSYYRSANGAILAYDITKRSSFLSVPHWIEDVRKYAGSNIVQLLIGNKSDLSELREVSLA 144

  Fly   134 QGFNYA-HRGALGFEEVSAKSGMNVYDIFSSLAMDIYHRYVLHNPISPMPSEQEEEDAAESPD 195
            :..:.| |...|...|.|||...||.:.|..:|.::..|:.     .|:.||       :|||
Human   145 EAQSLAEHYDILCAIETSAKDSSNVEEAFLRVATELIMRHG-----GPLFSE-------KSPD 195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RabX2	NP_572627.1	RAB	8..171	CDD:197555	60/163 (37%)
RabX2	NP_572627.1	Rab	8..165	CDD:206640	59/157 (38%)
RAB43	NP_001191812.1	Rab19	16..180	CDD:133267	62/163 (38%)
RAB43	NP_001191812.1	Effector region. /evidence=ECO:0000250	47..55		2/7 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.770