Protein Alignment RabX2 and RAB35

DIOPT Version :10

• Sequence 1: NP_572627.1
• Gene: RabX2 / 31971
• FlyBaseID: FBgn0030200
• Length: 195
• Species: Drosophila melanogaster
• Sequence 2: NP_006852.1
• Gene: RAB35 / 11021
• HGNCID: 9774
• Length: 201
• Species: Homo sapiens
• Alignment Length: 187
• Identity: 76/187 - (40%)
• Similarity: 123/187 - (65%)
• Gaps: 10/187 - (5%)

  Fly     4 FDYLFKVLVLGDSGVGKSCLLMRFSDDRFTEKYLRTMGIDVKARSVELVSRVMMLQVWDTSGDKR 68
            :|:|||:|::||||||||.||:||:|:.|:..|:.|:|:|.|.|:||:....:.||:|||:|.:|
Human     5 YDHLFKLLIIGDSGVGKSSLLLRFADNTFSGSYITTIGVDFKIRTVEINGEKVKLQIWDTAGQER 69

  Fly    69 FNSLMPSNYRSAHGILLVYDITSSKSFQNIDGWMKEIRRMCPDKVTVLLVGNKSDDPNHRQVSME 133
            |.::..:.||..||:::|||:||::||.|:..|:.||.:.| |.|..:|||||:|||..:.|..|
Human    70 FRTITSTYYRGTHGVIVVYDVTSAESFVNVKRWLHEINQNC-DDVCRILVGNKNDDPERKVVETE 133

  Fly   134 QGFNYAHRGALGFE--EVSAKSGMNVYDIFSSLAMDIYHRYVLHNPISPMPSEQEEE 188
            ..:.:|  |.:|.:  |.|||..:||.::|:.:.     ..||......:..:|:::
Human   134 DAYKFA--GQMGIQLFETSAKENVNVEEMFNCIT-----ELVLRAKKDNLAKQQQQQ 183

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RabX2	NP_572627.1	Rab	8..165	CDD:206640	71/158 (45%)
RAB35	NP_006852.1	Rab35	3..201	CDD:133310	76/187 (41%)
		Switch 1. /evidence=ECO:0000269|PubMed:30905672, ECO:0007744|PDB:6IF2, ECO:0007744|PDB:6IF3	30..42		4/11 (36%)
		Switch 2. /evidence=ECO:0000269|PubMed:30905672, ECO:0007744|PDB:6IF2, ECO:0007744|PDB:6IF3	64..80		5/15 (33%)