DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0289 and PLXDC2

DIOPT Version :9

Sequence 1:	NP_001303555.1	Gene:	l(1)G0289 / 31964	FlyBaseID:	FBgn0028331	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_011518052.1	Gene:	PLXDC2 / 84898	HGNCID:	21013	Length:	564	Species:	Homo sapiens

Alignment Length:	524	Identity:	173/524 - (33%)
Similarity:	252/524 - (48%)	Gaps:	94/524 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 RKTYDVAPAVDSNTTSQMAPATKKPTLLGQ-SGNPKKVASSVVAATMTDPSPAVIDVDVSKVVDV 195
            ::..|...|||:|..|           :|| |..|:         :.||   .::|
Human    66 KRNLDFLKAVDTNRAS-----------VGQDSPEPR---------SFTD---LLLD--------- 98

  Fly   196 PEEEIEAAVKNASLKESVDFHEYYNSVLYENKDEVA-SLWTELKATPENI-----MLSSSHRRAM 254
                 :....|..::|..| |.||.|.:|...|..: .||..:....::.     :||::||:|.
Human    99 -----DGQDNNTQIEEDTD-HNYYISRIYGPSDSASRDLWVNIDQMEKDKVKIHGILSNTHRQAA 157

  Fly   255 TVELKFDFPFYGHFVRNITVATGGFLYTGEYVHSWLAATQYIAPLMANFDTSMSNDSFVRLHDNG 319
            .|.|.|||||||||:|.||||||||:||||.||..|.|||||||||||||.|:|.:|.||..|||
Human   158 RVNLSFDFPFYGHFLREITVATGGFIYTGEVVHRMLTATQYIAPLMANFDPSVSRNSTVRYFDNG 222

  Fly   320 TAFTAVWENVTLQDKPDFGKFTFSVTLYQSGDIVFAYMLVPTNINSIQDKEHPVKVGLSDAYII- 383
            ||....|::|.|||..:.|.|||..||...|.|:|.|..:|..:..|....||||||||||:::
Human   223 TALVVQWDHVHLQDNYNLGSFTFQATLLMDGRIIFGYKEIPVLVTQISSTNHPVKVGLSDAFVVV 287

  Fly   384 --DKQLFFARRKTIYEYHRVTFQQHEITNNTIIKLAAQPTCLGYNDCNSCINHNTTFTCLWCSVL 446
              .:|:...||:||||||||..|..:|||.:.:::...||||.:|.|..|::....|.|.|||.|
Human   288 HRIQQIPNVRRRTIYEYHRVELQMSKITNISAVEMTPLPTCLQFNRCGPCVSSQIGFNCSWCSKL 352

  Fly   447 NRCSTGTDRKKHEWLQMGCEATAIHTSSLCPALGDKGNNAAGQGKNGSANSGASANGATNTSTSS 511
            .|||:|.||.:.:|:..||...:  ...:|                    ........::.:|::
Human   353 QRCSSGFDRHRQDWVDSGCPEES--KEKMC--------------------ENTEPVETSSRTTTT 395

  Fly   512 SGSSTPVTEPSVMSTRAPHATAYIKPGVDHSSD----IHADGKVGNAELSKAEADNK----NVGV 568
            .|::|  |:..|::|.....|:.....:....|    :|.  |...|....:.|:.|    :.|:
Human   396 VGATT--TQFRVLTTTRRAVTSQFPTSLPTEDDTKIALHL--KDNGASTDDSAAEKKGGTLHAGL 456

  Fly   569 AFGFMVPICLVFAVTLWLFYAYRNPHTKSGQLLIQFRPSQ---------WSWRR--GEARYTAA- 621
            ..|.::.:.:|....|...|.|.:|.:.:....|:...|:         |..|.  |:.|:.|.
Human   457 IIGILILVLIVATAILVTVYMYHHPTSAASIFFIELWKSEVLKSGYGQGWFLREASGDNRFLAIF 521

  Fly   622 TIHM 625
            :.||
Human   522 SFHM 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0289	NP_001303555.1	PSI	421..477	CDD:279745	21/55 (38%)
PLXDC2	XP_011518052.1	NIDO	191..>282	CDD:295411	48/90 (53%)
PLXDC2	XP_011518052.1	PSI	327..372	CDD:279745	20/44 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141673
Domainoid	1	1.000	210	1.000	Domainoid score	I2820
eggNOG	1	0.900	-	-		E1_KOG3848
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41666
Inparanoid	1	1.050	278	1.000	Inparanoid score	I2933
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1361987at2759
OrthoFinder	1	1.000	-	-		FOG0003589
OrthoInspector	1	1.000	-	-		otm40613
orthoMCL	1	0.900	-	-		OOG6_105338
Panther	1	1.100	-	-	LDO	PTHR13055
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2460
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.760