DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0289 and Plxdc1

DIOPT Version :9

Sequence 1:	NP_001303555.1	Gene:	l(1)G0289 / 31964	FlyBaseID:	FBgn0028331	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_001157080.1	Gene:	Plxdc1 / 72324	MGIID:	1919574	Length:	507	Species:	Mus musculus

Alignment Length:	488	Identity:	170/488 - (34%)
Similarity:	254/488 - (52%)	Gaps:	48/488 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 VAPAVDS-NTTSQMAPATKKPTLLGQSGNPKKVASSVVAATMTDPSPAVIDVDV---SKVVD-VP 196
            ::||..: :...|.:..|.|.|..|.|..|::..:.|:     .|....:..|:   |..:| :|
Mouse    20 LSPATPAGHNEGQDSAWTAKRTRQGWSRRPRESPAQVL-----KPGKTQLSQDLGGGSLAIDTLP 79

  Fly   197 EEEIEAAVKNASLKESVDFHEYYNSVLY-ENKDEVASLWTELK-ATPENI----MLSSSHRRAMT 255
            :........:.|.:|  |.|.||.|.:| ..:.:...||.:|. |...::    :||||||:|..
Mouse    80 DNRTRVVALSLSPQE--DNHNYYVSRVYGPGEKQSQDLWVDLAVANRSHVKIHRILSSSHRQASR 142

  Fly   256 VELKFDFPFYGHFVRNITVATGGFLYTGEYVHSWLAATQYIAPLMANFDTSMSNDSFVRLHDNGT 320
            |.|.||||||||.:|.||:|||||::.|:.:|..|.||||:|||||||:...|::|.|...||||
Mouse   143 VVLSFDFPFYGHPLRQITIATGGFIFMGDMLHRMLTATQYVAPLMANFNPGYSDNSTVAYFDNGT 207

  Fly   321 AFTAVWENVTLQDKPDFGKFTFSVTLYQSGDIVFAYMLVPTNINSIQDKEHPVKVGLSDAYII-- 383
            .|...|::|.|||:.|.|.|||...|::.|.|||.|..:|..:..|...:||||.|||||::|
Mouse   208 VFVVQWDHVYLQDREDRGSFTFQAALHRDGRIVFGYKEIPMAVLDISSAQHPVKAGLSDAFMILN 272

  Fly   384 -DKQLFFARRKTIYEYHRVTFQQHEITNNTIIKLAAQPTCLGYNDCNSCINHNTTFTCLWCSVLN 447
             ..::..::|:||:|||||.....:||..:.::....||||.:..|::|::.|.||.|.||.||.
Mouse   273 SSPEVPASQRRTIFEYHRVELDSSKITTTSAVEFTPLPTCLQHQSCDTCVSSNLTFNCSWCHVLQ 337

  Fly   448 RCSTGTDRKKHEWLQMGCEATAIHTSSLCPALGDKGNNAAGQGKNGSANSGASA-NGATNTSTSS 511
            |||:|.||.:.|||..||...|  ....|....|..:.:|      |.:|..|. ||.:.||:|.
Mouse   338 RCSSGFDRYRQEWLTYGCAQEA--EGKTCEDFQDDSHYSA------SPDSSFSPFNGDSTTSSSL 394

  Fly   512 SGSSTPVTEPSVMSTRAPHATAYIKPGVDHSSDIHADGKVGNAELSKAEADNKNVGVAFGFMVPI 576
            ...|....:.:.::   |:|.....|  ||||             .|::....::|...|.::.:
Mouse   395 FIDSLTTEDDTKLN---PYAEGDGLP--DHSS-------------PKSKGPPVHLGTIVGIVLAV 441

  Fly   577 CLVFAVTLWLFYAYRNPHTKSGQLLIQFRPSQW 609
            .||.|:.|...|...:|::.:....|:.||..|
Mouse   442 LLVAAIILAGIYISGHPNSNAALFFIERRPHHW 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0289	NP_001303555.1	PSI	421..477	CDD:279745	25/55 (45%)
Plxdc1	NP_001157080.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..72		12/54 (22%)
		NIDO	160..>266	CDD:295411	52/105 (50%)
		PSI	311..355	CDD:279745	22/43 (51%)
		DUF4690	367..455	CDD:292384	26/111 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	367..386		5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	406..427		8/38 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	488..507
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831623
Domainoid	1	1.000	207	1.000	Domainoid score	I2877
eggNOG	1	0.900	-	-		E1_KOG3848
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	280	1.000	Inparanoid score	I2887
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1361987at2759
OrthoFinder	1	1.000	-	-		FOG0003589
OrthoInspector	1	1.000	-	-		otm42689
orthoMCL	1	0.900	-	-		OOG6_105338
Panther	1	1.100	-	-	O	PTHR13055
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5819
SonicParanoid	1	1.000	-	-		X2460
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.790