DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(1)G0289 and PLXDC1

DIOPT Version :9

Sequence 1:	NP_001303555.1	Gene:	l(1)G0289 / 31964	FlyBaseID:	FBgn0028331	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_065138.2	Gene:	PLXDC1 / 57125	HGNCID:	20945	Length:	500	Species:	Homo sapiens

Alignment Length:	405	Identity:	143/405 - (35%)
Similarity:	216/405 - (53%)	Gaps:	33/405 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 DFHEYYNSVLY-ENKDEVASLWTEL-KATPENI----MLSSSHRRAMTVELKFDFPFYGHFVRNI 272
            |.|.||.|.|| .::.....||.:: :|....:    :||::||:|..|.|.||||||||.:|.|
Human    87 DNHSYYVSRLYGPSEPHSRELWVDVAEANRSQVKIHTILSNTHRQASRVVLSFDFPFYGHPLRQI 151

  Fly   273 TVATGGFLYTGEYVHSWLAATQYIAPLMANFDTSMSNDSFVRLHDNGTAFTAVWENVTLQDKPDF 337
            |:|||||::.|:.:|..|.||||:|||||||:...|::|.|...||||.|...|::|.||...|.
Human   152 TIATGGFIFMGDVIHRMLTATQYVAPLMANFNPGYSDNSTVVYFDNGTVFVVQWDHVYLQGWEDK 216

  Fly   338 GKFTFSVTLYQSGDIVFAYMLVPTNINSIQDKEHPVKVGLSDAYII---DKQLFFARRKTIYEYH 399
            |.|||...|:..|.|||||..:|.::..|...:||||.|||||::|   ...:..:||::|:|||
Human   217 GSFTFQAALHHDGRIVFAYKEIPMSVPEISSSQHPVKTGLSDAFMILNPSPDVPESRRRSIFEYH 281

  Fly   400 RVTFQQHEITNNTIIKLAAQPTCLGYNDCNSCINHNTTFTCLWCSVLNRCSTGTDRKKHEWLQMG 464
            |:.....::|:.:.::....||||.:..|::|::.:.||.|.||.||.|||:|.||.:.||:..|
Human   282 RIELDPSKVTSMSAVEFTPLPTCLQHRSCDACMSSDLTFNCSWCHVLQRCSSGFDRYRQEWMDYG 346

  Fly   465 CEATAIHTSSLCPALGDKGNNAAGQGKNGSANSGASANGATNTSTSSSGSSTPVTEPSVMSTRAP 529
            |...|  ...:|....|:.:::|....:.|...|    ..|.||:|....|....:.:.::   |
Human   347 CAQEA--EGRMCEDFQDEDHDSASPDTSFSPYDG----DLTTTSSSLFIDSLTTEDDTKLN---P 402

  Fly   530 HATAYIKPGVDHSSDIHADGKVGNAELSKAEADNKNVGVAFGFMVPICLVFAVTLWLFYAYRNPH 594
            :|              ..||...|.. .|.:....::|...|.::.:.||.|:.|...|...:|.
Human   403 YA--------------GGDGLQNNLS-PKTKGTPVHLGTIVGIVLAVLLVAAIILAGIYINGHPT 452

  Fly   595 TKSGQLLIQFRPSQW 609
            :.:....|:.||..|
Human   453 SNAALFFIERRPHHW 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0289	NP_001303555.1	PSI	421..477	CDD:279745	23/55 (42%)
PLXDC1	NP_065138.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..39
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	46..78
		NIDO	152..>242	CDD:295411	45/89 (51%)
		MGC-24	303..441	CDD:283050	44/161 (27%)
		PSI	303..347	CDD:279745	20/43 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	359..379		4/23 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	479..500
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141674
Domainoid	1	1.000	210	1.000	Domainoid score	I2820
eggNOG	1	0.900	-	-		E1_KOG3848
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	278	1.000	Inparanoid score	I2933
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1361987at2759
OrthoFinder	1	1.000	-	-		FOG0003589
OrthoInspector	1	1.000	-	-		otm40613
orthoMCL	1	0.900	-	-		OOG6_105338
Panther	1	1.100	-	-	O	PTHR13055
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5819
SonicParanoid	1	1.000	-	-		X2460
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790